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招聘信息

外专千人团队招聘博士后

发表日期:2018-05-28来源:放大 缩小

2 Postdoctoral Positions to study chromatin function and structure in stem and reprogrammed cells at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences Guangzhou, China

Pia Cosma Reprogramming and Regeneration Laboratory 1000 Talent awarded

The  Guangzhou  Institutes  of  Biomedicine and   Health  (GIBH, http://english.gibh.cas.cn/about/at/) is focused  in  research  areas  including  stem  cell  and regenerative  medicine,  chemical  biology,  immunology  and  infectious  diseases.  Aimed  to achieve  the goal of "Healthy  China"  strategy  and satisfy  human  health demands,  GIBH is exploring disease mechanism with the cutting--edge  technologies and developing innovative protocols   for  disease   control   and  prevention.   It  provides   excellent   R&D  platform   in biomedicine and functions as an incubator for bioengineering and pharmaceutical industries to support local economic development as well as national strategic R&D programs. Reprogramming and Regeneration Laboratory

Pia  Cosmas  group  is  an  internationally  recognized  laboratory (http://piacosmalab.com/) and will start at GIBH in August 2018. The group has as main objective to investigate the mechanisms controlling the reprogramming of somatic cells, and to determine if this reprogramming contributes to tissue regeneration in higher vertebrates. Cosmas  group  has  discovered  that  activation  of  the  Wnt/β--catenin  signalling  pathway enhances cell--fusion--mediated  reprogramming  of somatic cells and studied extensively the mechanism behind (Lluis et al., Cell Stem Cell 2008; Stem Cells 2010; PNAS 2011; Aulicino et al., Stem Cell Report 2014; Marucci et al. Cell Reports 2014; De Jaime--Soguero et al. Plos Genetics 2017). Cosmas group demonstrated that regeneration of the retina, dopaminergic neurons in Parkinsons disease and of liver after hepatectomy is possible via Wnt controlled cell--fusion--mediated   reprogramming   (Sanges   et   al.,   Cell   Reports   2013;   J.   of   Clinical Investigation  2016; Pesaresi  et al. eBioMedicine  2018; Altarche--Xifro  eBioMedicine  2016; Pedone et al., Cell Reports 2017).  

In addition, Cosmas Group has a long interest in studying gene and chromatin function 

(Cantone et al, Cell 2009). Recently using super resolution microscopy (STORM), the group has  identified  a  new  model  of  chromatin  fiber  assembly  and  how  the  fiber  changes  in somatic and embryonic stem cells (Ricci et al. Cell 2015, Neguembor et al., NAR 2017).  

We are currently studying the changes in chromatin structure and organization during somatic cell reprogramming and differentiation, to determine how chromatin fibers can be rearranged to overcome epigenetic barriers to gain pluripotency.  

Post Description and Candidate requirements

The Cosma group is looking for a highly motivated research scientist with consolidated expertise in biomedicine, biophysics or related disciplines. The candidate will hold a PhD and will preferentially have experience with cell culture and microscopy. Experience in the area of super resolution microscopy and/or CRISPR/Cas engineering will be considered an added value.  If necessary,  the successful  candidate  will be trained  in STORM  microscopy  at the CRG, Barcelona, Spain for few months before to move and work at the GIBH, Guangzhou.  Conditions

The  offer  is  to  cover  a  Postdoctoral  position  with  a  very  competitive  salary  that  will  be

well matched relative to the cost of living in Barcelona and Guangzhou.

Starting Date: The fellowship will start ideally as soon as the candidate is hired. Application Procedure

All applications  must be addressed  to Pia Cosma;  and include  a full CV with contact details,  a  cover  motivation  letter  and  contacts  of  2--3  references.  Please  submit  your application at: pia.cosma@crg.eu

Deadline  July  31  2018  (note  that  applications  will  be  continually  monitored  and  suitable

candidates will be hired as soon as they are identified)

 

 pls send your CV to pia.cosma@crg.eu

 

 必备条件:年龄35岁以下,已取得博士学位,且取得学位不得超过3年。

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