| 论文编号: |
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| 第一作者所在部门: |
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| 中文论文题目: |
Palladium-Catalyzed Modular Synthesis of Enantioenriched Pyridohelicenes through Double Imidoylative Cyclization |
| 英文论文题目: |
Palladium-Catalyzed Modular Synthesis of Enantioenriched Pyridohelicenes through Double Imidoylative Cyclization |
| 作者: |
Ting Yu, Zhong-Qiu Li, Jing Li, Sidi Cheng, Jiali Xu, Jun Huang, Yu-Wu Zhong*, Shuang Luo* and Qiang Zhu* |
| 论文出处: |
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| 刊物名称: |
ACS Catalysis |
| 年: |
2022 |
| 卷: |
12 |
| 期: |
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| 页: |
13034-13041 |
| 联系作者: |
Qiang Zhu |
| 收录类别: |
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| 影响因子: |
13.700 |
| 摘要: |
Enantioenriched pyrido[6]helicenes and furancontaining pyrido[7]helicenes have been synthesized through palladium-catalyzed double imidoylative cyclization by applying axially achiral multiaryl bisisocyanides and aryl iodides as coupling components. Two pyridyl rings were constructed sequentially by forming four C？C bonds in one pot with low catalyst loading. A control study using precyclized biaryl monoisocyanides revealed the second pyridine-forming enantiomer-generating step, which also enabled the introduction of different substituents, including trifluoromethyl, on the helical skeleton. This general and convergent approach to structurally diversified optically pure pyridohelicenes paves the way for optical studies and potential applications of this important class of azahelicenes.
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| 英文摘要: |
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