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专家人才

  • 姓名： 朱强
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 020-32015287
  • 传真： 
  • 电子邮件: zhu_qiang@gibh.ac.cn
  • 通讯地址 广州市萝岗区科学城开源大道190号B区307

    简历：

  • 　朱强实验室网页 

    　　研究经历:  

    　　2008年5月 至今 中国科学院广州生物医药与健康研究院 PI，研究员  

    　　2005年9月 至 2008年2月 美国公司 XTL Biopharmaceuticals Inc. staff scientist  

    　　2001年4月 至 2005年9月 美国公司 Vivoquest, Inc. staff scientist 

    　　2000年8月 至 2001年4月美国科罗拉多州立大学化学系博士后 

    　　  

    　　教育背景： 

    　　1995年9月 至 2000年6月 中国科学院上海有机化学研究所博士学位 

    　　1991年9月 至 1995年6月 南京大学化学化工学院本科学位 

    研究领域：

  • 　　

    　　（1）C？H键官能化反应用于杂环化合物合成方法研究； 

    　　（2）Cu/O2 体系对有机小分子的选择性氧化； 

    　　（3）异腈参与的新反应研究； 

    　　（4）药物分子合成工艺的改进； 

    　　（5）抗肺癌，抗肺结核药物开发。 

    承担科研项目情况：

  • 1．国家自然科学基金科学部主任基金（20942001）“异腈参与的多取代喹啉的合成研究”，2009年1月至2009年12月，8万元，主持，已结题。

    2．广州市科技计划项目（2010Y1-C241）“以邻炔基苯胺为原料合成几类重要的含氮杂环”，2011年1月至2011年12月，6万元，主持，已结题。

    3．国家自然科学基金面上项目（21072190）“通过分子内C-H键官能化合成几类杂环化合物的新方法研究”，2011年1月至2013年12月，36万元，主持，已结题。

    4. 2011年广东省自然科学基金重点项目(S2011020000806)“铜/氧气体系催化的烯烃脱氢氧胺化反应极其应用研究”，2011年1月至2013年12月，30万元，主持，已结题。

    5.中国科学院“百人计划”（人才项目）2011年1月至2013年12月，200万元，主持，已结题。

    6. 国家自然科学基金面上项目(21272233)“高价碘试剂催化的氧化环化反应研究”, 2013年至2016年, 80万元，主持，已结题。

    7．国家自然科学基金青年基金(21202167) “铜/氧气体系催化的烯烃脱氢氧胺化反应研究” 2013年至2015年，25万元，课题组成员黄金波博士主持，已结题。

    8. 广东省自然科学基金(2014A030313796) 2015年至2017年，10万元，课题组成员黄金波博士主持，已结题。

    9. 中国科学院青年创新促进会（人才项目） 2015年至2018年，60万元，课题组成员罗爽博士主持，在研。

    10. 国家自然科学基金面上项目(21472190)“钯催化的亚胺基化环化反应用于构建杂环化合物的研究”, 2015年至2018年, 95万元，主持，在研。

    11．国家自然科学基金青年基金(21402203) “过渡金属催化的双碳氢键的羰基化反应” 2015年至2017年，25万元，课题组成员罗爽博士主持，已结题。

    12. 国家自然科学基金重点项目项目(21532009)“过渡金属催化烯烃的氧化官能化新反应研究”, 2016年至2020年, 180 万元，参与，在研。(上海有机化学研究所刘国生研究员主持，总经费380万元)

    13. 国家自然科学基金面上项目(21672215)“吲哚-2-酮-3-螺噻嗪酮类化合物的抗结核活性研究”, 2017年至2020年, 65万元，课题组成员黄金波博士主持，在研。

    14．国家自然科学基金面上项目(21772198)“钯催化的不对称亚胺基化反应研究”, 2018年至2021年, 64万元，课题组成员罗爽博士主持，在研。

    社会任职：

  •  

    获奖及荣誉：

  • 　　1998年，上海有机化学研究所首届刘铸晋奖 

    　　2012年，中科院广州教育基地优秀研究生导师 

    　　2012年，中科院优秀研究生导师奖 

    代表论著：

  • 2018年
    59. Cascade double isocyanide insertion and C–N coupling of 2-iodo-2′-isocyano-1,1′-biphenyls
    Hongwei Sun, Shi Tang, Dengke Li, Yali Zhou, Jinbo Huang* and Qiang Zhu*
    Org. Biomol. Chem. 2018, 16, 3893-3896. Impact factor: 3.423

    58. PhI(OAc)2-Mediated Dearomative C–N Coupling: Facile Construction of the Spiro[indoline-3,2’-pyrrolidine] Skeleton
    Yali Zhou, Dengke Li, Shi Tang, Hongwei Sun, Jinbo Huang* and Qiang Zhu*
    Org. Biomol. Chem. 2018, 16, 2039-2042. Impact factor: 3.423
            
    57. Pd-Catalzed Divergent C(sp2)–H Activation/Cycloimidlylation of 2-Isocyano-2,3-diarylpropanoates
    Shi Tang, Sheng-Wen Yang, Hongwei Sun, Yali Zhou, Juan Li* and Qiang Zhu*
    Org. Lett. 2018, 20, 1832-1836. Impact factor:6.492

    56. Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via
    Palladium-Catalyzed Imidoylative Cyclization Reactions
    Shuang Luo,* Zhuang Xiong, Yongzhi Lu and Qiang Zhu*
    Org. Lett. 2018, 20, 1837-1840. Impact factor:6.492

    55. Stirring-Controlled Mono or Double Aminocarbonylation of 1,3-Bis(2-
    iodoaryl)propan-2-amines
    Huaanzi Hu, Zeqiang Xie, Shuang Luo* and Qiang Zhu*
    Tetrahedron Lett. 2018, 59, 1034-1037. Impact factor:2.125

    2017年
    54. Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to β-Carbolines
    Shi Tang, Jian Wang, Zhuang Xiong, Zeqiang Xie, Dengke Li, Jinbo Huang* and Qiang Zhu*
    Org. Lett. 2017, 19, 5577-5580. Impact factor:6.492.

    53. Palladium-Catalyzed C(sp2)–H Aminoimidoylation of Isocyano-Containing Arenes: Synthesis of Amino Substituted N-Heterocycles
    Zhuang Xiong, Jian Wang, Yanbo Wang, Shuang Luo* and Qiang Zhu*
    Org. Chem. Front. 2017, 4, 1768-1771. Impact factor:5.455

    52. Copper-Catalyzed Regioselective 1,2-Thioamidation of Alkenes
    Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2017, 53, 3450-3453. Impact factor: 6.290

    51. A One-Pot Synthesis of [1,2,3]Triazolo[1,5-a]quinoxalines from 1-Azido-2-isocyanoarenes with High Bond-Forming E?ciency
    Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2017, 53, 1305-1308. Impact factor: 6.290

    50. Palladium-Catalyzed Enantioselective C(sp2)–H lmidoylation by Desymmetrization
    Jian Wang, De-Wei Gao, Jinbo Huang, Shi Tang, Zhuang Xiong, Huaanzi Hu, Shu-Li You* and Qiang Zhu*
    ACS Catal. 2017, 7, 3832-3836. Impact factor:11.384

    49. Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2 Substituted Benzoimidazoles from 1 Azido-2-isocyanoarenes
    Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
    Org. Lett. 2017, 19, 3223-3226. Impact factor:6.492

    2016年
    48. Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide
    Jian Wang, Shi Tang and Qiang Zhu*
    Org. Lett. 2016, 18, 3074-3077.

    47. Transition Metal-Free Amidoalkylation of Benzothiazoles and
    Amidoalkylarylation of Activated Alkenes with N,N-Dialkylamides
    Jian Wang, Jing Li, Jinbo Huang* and Qiang Zhu*
    J. Org. Chem. 2016, 81, 3017-3022.

    46. Pd-Catalyzed C(sp2)–H Carbonylation of 2-Benzylpyridines for the Synthesis of Pyridoisoquinolinones
    Zeqiang Xie, Shuang Luo* and Qiang Zhu*
    Chem. Commun. 2016, 52, 12873-12876.

    45. A Metal-Free Synthesis of 2-Aminobenzothiazoles through Aminyl Radical Addition to Arylisothiocyanates
    Yimiao He, Jing Li, Shuang Luo, Jinbo Huang* and Qiang Zhu*
    Chem. Commun. 2016, 52, 8444-8447.

    44. Copper-Mediated C(sp3)–H Azidation with Me3SiN3: Synthesis of Imidazoles from Ketones and Aldehydes
    Zeqiang Xie, Jiaojiao Deng, Zhiping Qiu, Juan Li* and Qiang Zhu*
    Chem. Commun. 2016, 52, 6467-6470.

    43. Dearomative C–C and C–N Bond Cleavage of 2-Arylindoles: Transition-Metal-Free Access to 2-Aminoarylphenones
    Shuang Luo,* Ziwei Hu and Qiang Zhu*
    Org. Chem. Front. 2016, 3, 364-367.

    42. Copper-Mediated C(sp3)–H Amination in a Multiple C–N Bond-Forming Strategy for the Synthesis of N-heterocycles
    Zeqiang Xie, Jiangling Peng and Qiang Zhu*
    Org. Chem. Front. 2016, 3, 82-86.

    41. Recent Progress in Imydoyl Radical-Involved Reactions
    Jian Lei, Jinbo Huang and Qiang Zhu*
    Org. Biomol. Chem. 2016, 14, 2593-2602.

    2015年
    40. Palladium-Catalyzed Intramolecular C(sp2)–H Imidoylation for the Synthesis of Six-Membered N-Heterocycles
    Jing Li, Yimiao He, Shuang Luo, Jian Lei, Jian Wang, Zeqiang Xie and Qiang Zhu*
    J. Org. Chem. 2015, 80, 2223-2230.

    39. A Facile Synthesis of Pyrazoles through Metal-Free Oxidative C(sp2)–H Cycloamination of Vinyl Hydrazones
    Dongdong Liang and Qiang Zhu*
    Asian J. Org. Chem. 2014, 4, 42-45.

    38. Copper-Catalyzed Tri?uoromethylalkynylation of Isocyanides
    Jian Lei, Xiaoxing Wu* and Qiang Zhu*
    Org. Lett. 2015, 17, 2322-2325.

    37. Copper-Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols
    Jian Lei, Xiaowu Liu, Shaolin Zhang, Shuang Jiang, Minhao Huang, Xiaoxing Wu* and Qiang Zhu*
    Chem. Eur. J. 2015, 21, 6700-6703.

    36. Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates
    Ziwei Hu, Shuang Luo* and Qiang Zhu*
    Adv. Synth. Catal. 2015, 357, 1060-1064.

    35. Palladium-Catalyzed Intermolecular C–H Amidation of Indoles with Sulfonyl Azides
    Ziwei Hu, Shuang Luo* and Qiang Zhu*
    Sci. China. Chem. 2015, 58, 1349-1353.

    34. Surface Con?ned Retro Diels-Alder Reaction Driven by the Swelling of Weak Polyelectrolytes
    Beier Lyu, Wenli Cha, Tingting Mao, Yuanzi Wu, Hujun Qian, Qiang Zhu* and Hongwei Ma*
    ACS Appl. Mater. Interfaces 2015, 7, 6254-6259.

    2014年
    33. Arylative Cyclization of 2-Isocyanobiphenyls with Anilines: One-Pot Synthesis of 6-Arylphenanthridines via Competitive Reaction Pathways
    Zhonghua Xia, Jinbo Huang, Yimiao He, Jiaji Zhao, Jian Lei and Qiang Zhu*
    Org. Lett. 2014, 16, 2546-2549.

    32. Palladium-Catalyzed C(sp2)–H Pyridocarbonylation of N-Aryl-2-aminopyridines: Dual Function of the Pyridyl Moiety
    Dongdong Liang, Yimiao He and Qiang Zhu*
    Org. Lett. 2014, 16, 2748-2751.

    31. Palladium-Catalyzed Imidoylative Cyclization of α-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles
    Jian Wang, Shuang Luo, Jinbo Huang, Tingting Mao and Qiang Zhu*
    Chem. Eur. J. 2014, 20, 11220-11224.

    30. Copper-Mediated C(sp2)–H Amination Using TMSN3 as a Nitrogen Source: Redox-Neutral Access to Primary Anilines
    Jiangling Peng, Ming Chen, Zeqiang Xie, Shuang Luo and Qiang Zhu*
    Org. Chem. Front. 2014, 1, 777-781.

    29. Copper-Catalyzed C(sp2)–H Amidation with Azides as Amino Sources
    Jiangling Peng, Zeqiang Xie, Ming Chen, Jian Wang and Qiang Zhu*
    Org. Lett. 2014, 16, 4702-4705.

    28. A Room-Temperature Synthesis of 2,2’-Bisoxazoles through Palladium-Catalyzed Oxidative Coupling of α-Isocyanoacetamides
    Jian Wang, Shuang Luo, Jing Li and Qiang Zhu*
    Org. Chem. Front. 2014, 1, 1285-1288.

    27. Copper-Catalyzed Intramolecular Oxidative C(sp3)–H Amidation of 2-Amino- acetophenones: Efficient Synthesis of Indoline-2,3-diones
    Jinbo Huang*, Tingting Mao and Qiang Zhu*
    Eur. J. Org. Chem. 2014, 2878-2882.

    2013年
    26. Synthesis of Phenanthridinones via Palladium-Catalyzed C(sp2)–H Aminocarbonylation of Unprotected o-Arylanilines
    Dongdong Liang, Ziwei Hu, Jiangling Peng, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2013, 49, 173-175.

    25. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular Oxidative C(sp2)–H Amination of o-N-Methylaminobenzophenones
    Jinbo Huang, Congqing Wan, Ming-Fang Xu* and Qiang Zhu*
    Eur. J. Org. Chem. 2013, 1876-1880.

    24. C–H Cycloamination of N-Aryl-2-aminopyridines and N-Arylamidines Catalyzed by an in situ Generated Hypervalent Iodine(III) Reagent
    Yimiao He, Jinbo Huang, Dongdong Liang, Lanying Liu and Qiang Zhu*
    Chem. Commun. 2013, 49, 7352-7354.

    23. A Metal-Free Tandem Demethylenation/C(sp2)–H Cycloamination Process of N?Benzyl-2-aminopyridines via C–C and C–N Bond Cleavage
    Dongdong Liang, Yimiao He, Lanying Liu and Qiang Zhu*
    Org. Lett. 2013, 15, 3476-3479.

    22. A Transition-Metal-Free Synthesis of Arylcarboxyamides from Aryl Diazonium Salts and Isocyanides
    Zhonghua Xia and Qiang Zhu*
    Org. Lett. 2013, 15, 4110-4113.

    21. Synthesis of 1H-Indole-3-carboxamidines through a Palladium-Catalyzed Three-Component Reaction Involving Isocyanide Insertion as a Key Step
    Ziwei Hu, Jian Wang, Dongdong Liang and Qiang Zhu*
    Adv. Synth. Catal. 2013, 355, 3290-3294.

    2012 年
    20. Direct Carboxamidation of Indoles by Palladium-Catalyzed C–H Activation and Isocyanide Insertion
    Jiangling Peng, Lanying Liu, Ziwei Hu, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2012, 48, 3772-3774.

    19. Cu-Catalyzed Oxidative C(sp2)–H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans
    Jiaji Zhao, Yong Wang, Yimiao He, Lanying Liu, Qiang Zhu*
    Org. Lett. 2012, 14, 1078-1081.

    18. Cu-Catalyzed Regioselective C–H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group
    Jiaji Zhao, Yong Wang and Qiang Zhu*
    Synthesis 2012, 44, 1551-1555.

    17. Palladium(II)-Catalyzed Cycloamidination via C(sp2)–H Activation and Isocyanide Insertion
    Yong Wang and Qiang Zhu*
    Adv. Synth. Catal. 2012, 354, 1902-1908.

    16. Palladium-Catalyzed Cyclization of o-Alkynyltrifluoroacetanilides Followed by Isocyanide Insertion: Synthesis of 2-Substituted 1H-Indole-3-carboxamides
    Ziwei Hu, Dongdong Liang, Jiaji Zhao, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2012, 48, 7371-7373.

    15. Palladium-Catalyzed C(sp2)–H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source
    Jiangling Peng, Jiaji Zhao, Ziwei Hu, Dongdong Liang, Jinbo Huang and Qiang Zhu*
    Org. Lett. 2012, 14, 4966-4969.

    14. CuI-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols: Synthesis of 2- or 4-Iododibenzofurans and Mechanistic Studies
    Jiaji Zhao, Qi Zhang, Lanying Liu, Yimiao He, Jing Li, Juan Li* and Qiang Zhu*
    Org. Lett. 2012, 14, 5362-5365.

    13. Synthesis of Benzimidazoles by PIDA-Promoted Direct C(sp2)–H Imidation of N-Arylamidines
    Jinbo Huang, Yimiao He, Yong Wang and Qiang Zhu*
    Chem. Eur. J. 2012, 18, 13964-13967.

    2011 年
    12. Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines
    Yong Wang, Honggen Wang, Jiangling Peng and Qiang Zhu*
    Org. Lett. 2011, 13, 4604-4607.

    11. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-Spiro-3,4-dihydro-2-(1H)- quinazolinones
    Honggen Wang, Jiaji Zhao, Jiancun Zhang* and Qiang Zhu*
    Adv. Synth. Catal. 2011, 353, 2653-2658.

    10. Sequential Hydration-Condensation-Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles
    Lijie Peng, Honggen Wang, Changlan Peng, Ke Ding* and Qiang Zhu*
    Synthesis 2011, 1723-1732.

    9. Synthesis of Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular C(sp2)–H Carboxamidation of N-Arylamidines
    Bin Ma, Yong Wang, Jiangling Peng and Qiang Zhu*
    J. Org. Chem. 2011, 76, 6362-6366.

    8. Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles
    Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang* and Qiang Zhu*
    Angew. Chem., Int. Ed. 2011, 50, 5678-5681.

    2010 年
    7. Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of ortho-Alkynylaryl Isocyanides
    Jiaji Zhao, Changlan Peng, Lanying Liu, Yong Wang and Qiang Zhu*
    J. Org. Chem. 2010, 75, 7502-7504.

    6. A Direct Intramolecular C–H Amination Reaction Co-Catalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines
    Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
    J. Am. Chem. Soc. 2010, 132, 13217-13219.

    5. p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines
    Changlan Peng, Yong Wang, Lanying Liu, Honggen Wang, Jiaji Zhao and Qiang Zhu*
    Eur. J. Org. Chem. 2010, 818-822.
    4. Structure-Based Design, Synthesis and Biological Evaluation of New N-Carboxyphenylpyrrole Derivatives as HIV Fusion Inhibitors Targeting gp41
    Yong Wang, Hong Lu, Qiang Zhu*, Shibo Jiang* and Yun Liao*
    Bioorg. Med. Chem. Lett. 2010, 20, 189-192.

    2009 年
    3. An Efficient Synthesis of 4-Alkyl-2(1H)-quinazolinones and 4-Alkyl-2-chloroquinazolines from 1-(2-Alkynylphenyl)ureas
    Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
    Tetrahedron Lett. 2009, 50, 6841-6843.

    2. Tetrabutylammonium Chloride-Triggered 6-endo Cyclization of o-Alkynylisocyanobenzenes: an Efficient Synthesis of 2-Chloro-3-Substituted Quinolines
    Lanying Liu, Yong Wang, Honggen Wang, Changlan Peng, Jiaji Zhao and Qiang Zhu*
    Tetrahedron Lett. 2009, 50, 6715-6719.

    1. Sulfuric Acid Promoted Condensation Cyclization of 2-(2-(Trimethylsilyl)ethynyl)anilines with Arylaldehydes in Alcoholic Solvents: an Efficient One-Pot Synthesis of 4-Alkoxy-2-arylquinolines
    Yong Wang, Changlan Peng, Lanying Liu, Jiaji Zhao, Li Su and Qiang Zhu*
    Tetrahedron Lett. 2009, 50, 2261-2265.

    专利：
    1. 吴东海, 朱强, 杨松, 刘兰英, 彭长兰
    青蒿素衍生物的新应用，ZL201010216620.0

    2. 朱强, 王洪根, 王勇, 梁冬冬, 刘兰英, 张健存
    咪唑[1,2-a]吡啶和咪唑醛类化合物的新合成方法, 专利号：201110110748.3

    3. 朱强, 张天宇, 刘兰英, 鲁明辉, 毛婷婷，黄金波
    吲哚[3,2-c]喹啉类化合物或其药学上可接受的盐及其制备方法和应用, 中国专利号：201310385431.X

    4. 涂正超，朱强，张天宇，黄金波，徐晓冰，万军庭，黎敏科，李登科，周亚丽，刘志永，王邦兴，米琦.托特雷拉
    吲哚-2-酮-3-螺噻嗪或噻唑酮化合物及其应用，中国专利号：CN201610657161.7