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专家人才

  • 姓名： 姚红杰
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 020-32015279
  • 传真： 
  • 电子邮件: yao_hongjie@@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历：

  • 姚红杰，博士，研究员，健康研究中心主任，国家杰出青年科学基金获得者，国家重点研发计划项目负责人。2005年毕业于中国科学院植物研究所，获理学博士学位。从2005年11月出国留学，先后在美国宾夕法尼亚州立大学、美国国立卫生研究院等机构从事博士后研究工作，主要从事表观遗传及染色质组织对基因表达调控的机理研究。2011年10月加入中国科学院广州生物医药与健康研究院，建立“干细胞表观遗传调控”研究组，任课题组长、研究员、博士生导师。2012年获得中科院人才计划择优支持（终期评估优秀）。作为课题负责人先后承担来自国家自然科学基金、国家重点研发计划、中科院战略性先导科技专项、广东省重点领域研发计划项目的资助；参加科技部干细胞重大科学研究计划（973）项目。近年来，相关研究成果以通讯作者分别发表在Cell Stem Cell, Science Advances, Nature Communications, Nucleic Acids Research, Cell Reports等学术刊物上。

    研究领域：

  • 1）干细胞命运调控的表观遗传机制

    2）人类疾病的干细胞模型、动物模型的建立和致病机制研究

    3）肿瘤发生发展的表观 遗传调控机制

    承担科研项目情况：

  • 国家杰出青年科学基金项目

    国家科技部重点研发计划

    国家自然科学基金联合基金重点项目

    中科院器官重建与制造先导专项

    广东省重点领域研发计划项目

    社会任职：

  • 中国生物化学与分子生物学学会基因专业委员会 委员

    中国生物化学与分子生物学学会核糖核酸专业委员会 委员

    中国生物物理学会衰老生物学分会 委员

    Scientific Reports, 编委

    获奖及荣誉：

  • 2021 国家重点研发计划首席科学家

    2021 广州市黄埔区杰出人才

    2020 臻溪生命科学优秀教育工作者

    2019 国家杰出青年科学基金获得者

    2018 中国科学院广州教育基地“优秀研究生导师”

    2017 中国科学院院级人才计划终期评估优秀

    2016 中国科学院广州分院“优秀青年科学家”

    2012 中国科学院院级人才计划入选者

    2010 美国国立卫生研究院“研究员卓越研究奖”

    2004 中国科学院院长奖学金优秀奖

    2001 山西省“兴晋挑战杯”高校青年师生学术科技作品竞赛优秀奖

    代表论著：

  • 1)        Dong X, Guo R, Ji T, Zhang J, Xu J, Li Y, Sheng Y, Wang Y, Fang K, Wen Y, Liu B, Hu G, Deng H, Yao H*. YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency.  Nucleic Acids Research 2022. Apr 15: gkac230. doi: 10.1093/nar/gkac230. (Breakthrough Article)

    2)        Song Y, Liang Z, Zhang J, Hu G, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng YL, Li H, Chen Z, Gao M, Chen Y, Shan G, Zhang MQ, Shan G, Hutchins AP, Fu X-D*, Yao H*. CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Reports 2022. Apr 5;39(1):110626.

    3)        Hu G, Dong X, Gong S, Song Y, Hutchins AP, Yao H*. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Research 2020. 48(17): 9606-9620.

    4)        Li Y, Song Y, Xu W, Li Q, Wang X, Li K,Wang J, Liu Z, Velychko S, Ye R, Xia Q, Wang L, Guo R, Dong X, Zheng Z, Dai Y, Li H, Yao M, Xue Y, Scho？ler HR, Sun Q*, Yao H*. R-Loops Coordinate with SOX2 in Regulating Reprogramming to Pluripotency. Science Advances 2020. 6(24): eaba0777. 

    5)        Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen Y-S, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang Y-G, Yao H*. An Alternative CTCF Isoform Antagonizes Canonical CTCF Occupancy and Changes Chromatin Architecture to Promote Apoptosis. Nature Communications 2019. 10(1): 1535. doi.org/10.1038/s41467-019-08949-w. (Highlighted by Nature Communications Editor).

    6)        Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Sun H, Wang H, Yao H*. PCGF5 is Required for Neural Differentiation of Embryonic Stem Cells. Nature Communications 2018. 9(1):1463. doi: 10.1038/s41467-018-03781-0.

    7)        Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H*. RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-based Repression of RYBP and its PRC1-dependent and -independent Functions. Cell Stem Cell 2017. 20(4):462-477. (Previewed by Cell Stem Cell).

    8)        Li W, Shang L, Huang K, Li J, Wang Z, Yao H*. Identification of Critical Base Pairs Required for CTCF Binding in Motif M1 and M2. Protein & Cell 2017. 8: 544-549. 

    9)        Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G*, Yao H*. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation 2021 Mar 5:e13000. doi: 10.1111/cpr.13000.

    10)     Song Y, Hu G, Jia J, Yao M, Wang X, Lu W, Hutchins AP, Chen J, Ozato K, Yao H*. DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner. Front Mol Biosci. 2020. 7: 618088. 

    11)     Ping W, Hu J, Hu G, Li H, Song Y, Xia Q, Yao M, Gong S, Jiang C*, Yao H*. Genome-wide DNA Methylation Analysis Reveals that Mouse Chemical iPSCs Have Closer Epigenetic Features to mESCs than OSKM-integrated-iPSCs. Cell Death & Disease 2018. 9(2):187. 

    12)     Shan Y, Liang Z, Xing Q, Zhang T, Wang B, Tian S, Huang W, Zhang Y, Yao J, Zhu Y, Huang K, Liu Y, Wang X, Chen Q, Zhang J, Shang B, Li S, Shi X, Liao B, Zhang C, Lai K, Zhong X, Shu X, Wang J, Yao H, Chen J, Pei D, Pan G*. PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not na？ve ESCs. Nature Communications 2017. 8(1):672. doi: 10.1038/s41467-017-00668-4.

    13)     Peng X, So KK, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S, Yao H, Hu P, Sun H*, Wang H*. MyoD and FoxO3 mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Research 2017. 45: 8785-8805.

    14)     Huang K, Zhang X, Shi J, Yao M, Lin J, Li J, Liu H, Li H, Shi G, Wang Z, Zhang B, Chen J, Pan G, Jiang C, Pei D*, Yao H*. Dynamically Reorganized Chromatin is the Key for the Reprogramming of Somatic Cells to Pluripotent Cells. Scientific Reports 2015. 5:17691. doi: 10.1038/srep17691.

    15)     Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J*, Pei D*. The Oncogene c-Jun Impedes Somatic Cell Reprogramming. Nature Cell Biology 2015. 17:856-67.

    16)     Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA*. Transcriptional Pause Release is a Rate-limiting Step for Somatic Cell Reprogramming. Cell Stem Cell 2014. 15: 574-588.

    17)     Huang K, Jia J, Wu C, Yao M, Li M, Jin J, Jiang C, Cai Y, Pei D, Pan G*, Yao H*. Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding factor (CTCF) is Negatively Regulated by the Condensin Complex. Journal of Biological Chemistry 2013. 288: 26067-26077.

    18)     Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, Wang X, Hu X, Gu T, Zhou Z, Liu J, Liu J, Wu H, Mao S, Mo K, Li Y, Lai K, Qi J, Yao H, Pan G, Xu GL*, Pei D*. Vitamin C Modulates TET1 Function during Somatic Cell Reprogramming. Nature Genetics 2013. 45:1504-1509.

    19)     Hu J＃, Yao H＃, Gan F, Tokarski A, Wang Y*. Interaction of OKL38 and p53 in Regulating Mitochondrial Structure and Function. PLoS One 2012. 7: e43362. (＃Equal contribution).

    20)     Pan G, Wang T, Yao H, Pei D*. Somatic Cell Reprogramming for Regenerative Medicine: SCNT vs. iPS Cells. Bioessays 2012. 34: 472-476.

    21)     Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z, Yao H, Felsenfeld G*. Chromatin Domains, Insulators, and the Regulation of Gene Expression. Biochim Biophys Acta 2012. 1819: 644-651.

    22)     Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero R, Felsenfeld G*. Mediation of CTCF Transcriptional Insulation by DEAD-box RNA-binding Protein p68 and Steroid Receptor RNA Activator SRA. Genes & Development 2010. 24: 2543-2555.

    23)     Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y*. Coordination of PAD4 and HDAC2 in the Regulation of p53-target Gene Expression. Oncogene 2010. 29: 3153-3162.

    24)     Yao H, Li P, Venters B, Zheng S, Thompson P, Pugh BF, Wang Y*. Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis. Journal of Biological Chemistry 2008. 283: 20060-20068.

    25)     Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H, Yao H, Ozato K*. The Bromodomain Protein Brd4 Stimulates G1 Gene Transcription and Promotes Progression to S Phase. Journal of Biological Chemistry 2008. 283: 9040-9048.

    26)     Tian S*, Yao H, Deng X, Xu X, Qin G, Chan Z. Characterization and Expression of beta-1, 3-Glucanase Genes in Jujube Fruit Induced by the Microbial Biocontrol Agent Cryptococcus laurentii. Phytopathology 2007. 97: 260-268.

    27)     Yao H, Tian S*. Effects of a Biocontrol Agent and Methyl Jasmonate on Postharvest Diseases of Peach Fruit and the Possible Mechanisms Involved. Journal of Applied Microbiology 2005. 98: 941-950.

    28)     Yao H, Tian S*. Effects of Pre- and Postharvest Application of Salicylic Acid or Methyl Jasmonate on Inducing Disease Resistance of Sweet Cherry Fruit in Storage. Postharvest Biology and Technology 2005. 35: 253-262.

    29)     Yao H, Tian S*. Wang Y. Sodium Bicarbonate Enhances Biocontrol Efficacy of Yeasts on Fungal Spoilage of Pears. International Journal of Food Microbiology 2004. 93: 297-304.