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专家人才

  • 姓名： 王金勇
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: wang_jinyong(AT)gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历：

  • 课题组简介

    王金勇，研究员，血液与免疫细胞再生研究组组长，国家自然科学基金杰出青年科学基金（2019医学部）获得者，中国科学院大学博士生导师。他的研究团队旨在结合体内诱导谱系重编程、体外诱导干细胞分化、造血骨髓微环境原位重建等多途径探索血液及免疫细胞再生与生理功能重建。其研究团队长期聚焦“抗白血病免疫细胞再生与白血病骨髓微环境原位修复”研究，在T细胞再生等领域取得一系列原创技术突破，拥有多项发明专利 

     

    个人经历

    2012年3月至今：中国科学院广州生物医药与健康研究院，研究员

    2007年9月-2012年2月：美国威斯康星医学院、威斯康星大学麦迪逊医学与公共卫生学院，博士后

    2006年8月-2007年8月：中国农业科学院上海兽医研究所， 博士后

    2001年-2006年：浙江大学， 博士

    1997年-2001年：莱阳农学院，学士

    研究领域：

  • 血液与免疫细胞再生

    承担科研项目情况：

    社会任职：

  •  

    获奖及荣誉：

  • 获国家杰出青年科学基金资助

    国家重点研发计划项目首席科学家

    代表论著：

  • 1. Wang, T., Xia, C., Weng, Q., Wang, K., Dong, Y., Hao, S., Dong, F., Liu, X., Liu, L., Geng, Y., Guan, Y., Du, J., Cheng, T., Cheng, H., Wang, J. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica, DOI: 10.3324/haematol.2019.239186.

    2. Wang, T., Lv, C., Hu, F., Liu, L., Wang, J. (2020) Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells. Blood Science 2, 79-88.

    3. Guo, R., Wu, H., Du, J., Wang, J. (2020) T cell regeneration: an update on progress and challenges. Blood Science 2, 22-26.

    4. Hu, F., Huang, D., Luo, Y., Zhou, P., LV, C., Wang, K., Weng, Q., Liu, X., Guan Y., Geng, Y., Du, J., Chen J., Wang, J., and Wu, H. (2020) Haematopoietic lineage-converted T cells carrying tumour associated antigen-recognizing TCRs effectively kill tumour cells. Journal for ImmunoTherapy of Cancer, DOI: 10.1136/jitc-2019-000498.

    5. LV, C., Chen, S., Hu, F., Huang, D., Wang, T., Du, J., Wang, J., and Wu, H. (2020) Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo. Cellular & Molecular Immunology, DOI: 10.1038/s41423-020-0429-4.

    6. Xia, C., Wang, T., Cheng, H., Dong, Y., Weng, Q., Sun, G., Zhou, P., Wang, K., Liu, X., Geng, Y., Ma, S., Hao, S., Xu, L., Guan, Y., Du, J., Du, X., Li, Y., Zhu, X., Shi, Y., Xu, S., Wang, D., Cheng, T., and Wang, J. (2020) Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia, 34(9):2375-2383.

    7. Guo, R., Hu, F., Weng, Q., Lv, C., Wu, H., Liu, L., Li, Z., Zeng, Y., Bai, Z., Zhang, M., Liu, Y., Liu, X., Xia, C., Wang, T., Zhou, P., Wang, K., Dong, Y., Luo, Y., Zhang, X., Guan, Y., Geng, Y., Du, J., Li, Y., Lan, Y., Chen, J., Liu, B., and Wang, J. (2020) Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors. Cell Research 30, 21-33.

    8. Weng, Q., Hu, F., Zhang, M., Dong, Y., Lv, C., Wang, Y., Liu, X., Wang, J. (2018) A protocol for generating induced T cells by reprogramming B cells in vivo. Cell Regeneration 7, 7-15.

    9. Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., Li, C., Zhou, P., Wang, T., Guan, Y., Guo, R., Liu, L., Geng, Y., Wu, H., Du, J., Hu, Z., Xu, S., Chen, J., He, A., Liu, B., Wang, D., Yang, Y. G., and Wang, J. (2018) Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nat Immunology 19, 279-290.

    10. Li, X., Xia, C., Wang, T., Liu, L., Zhao, Q., Yang, D., Hu, F., Zhang, M., Huang, K., Geng, Y., Zheng, Y., Guan, Y., Wu, H., Chen, X., Pan, G., Chen, J., Du, J., and Wang, J. (2017) Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Research 21, 32-39.

    11. Chen, X., Zhao, Q., Li, C., Geng, Y., Huang, K., Zhang, J., Wang, X., Yang, J., Wang, T., Xia, C., Liu, X., Meng, M., Yang, D., Zheng, Y., Du, J., Zhang, X., Chen, J., Pan, G., and Wang, J. (2015) OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo. Stem Cell Research 15, 395-402.

    12. Yang, D., Zhang, X., Dong, Y., Liu, X., Wang, T., Wang, X., Geng, Y., Fang, S., Zheng, Y., Chen, X., Chen, J., Pan, G., and Wang, J. (2015) Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo. Cell Cycle 14, 612-620.

    13. Wang, T., Li, C., Xia, C., Dong, Y., Yang, D., Geng, Y., Cai, J., Zhang, J., Zhang, X., and Wang, J. (2015) Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo. Am J Transl Res 7, 1963-1973.

    14. Wang, J., Kong, G., Liu, Y., Du, J., Chang, Y. I., Tey, S. R., Zhang, X., Ranheim, E. A., Saba-El-Leil, M. K., Meloche, S., Damnernsawad, A., Zhang, J., and Zhang, J. (2013) Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood 121, 5203-5207.

    15. Wang, J., Liu, Y., Li, Z., Wang, Z., Tan, L. X., Ryu, M. J., Meline, B., Du, J., Young, K. H., Ranheim, E., Chang, Q., and Zhang, J. (2011) Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 118, 368-379.

    16. Wang, J., Liu, Y., Li, Z., Du, J., Ryu, M. J., Taylor, P. R., Fleming, M. D., Young, K. H., Pitot, H., and Zhang, J. (2010) Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 116, 5991-6002.