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专家人才

  • 姓名： 巫林平
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: wu_linping@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 学习经历：

    2010-2002，丹麦哥本哈根大学，博士

    2005-2008，汕头大学多学科研究中心，硕士

    2001-2005，汕头大学理学院，学士

    工作经历：

    2016.10-至今     中国科学院广州生物医药与健康研究院，PI

    2013.01-2016.09  丹麦哥本哈根大学，博士后

    研究领域：

  • 致力于纳米转化医学研究，主要研究方向：

    1、核酸药物（疫苗）开发及其纳米靶向递送系统研究；

    2、生物材料合成及其微纳结构调控干细胞命运器官再造。

    承担科研项目情况：

  • 1.国家重点研发计划课题，诱导周围神经和血管原位再生的组织微环境适配导管支架研究， 782万元，2019-2023，负责人

    2.国家科技重大专项，抗骨关节炎siRNA候选药物临床前研究， 303.12万元，2018-2020，子任务负责人

    3.广东省科技计划项目，多功能聚羟基脂肪酸酯（PHAs）在siRNA药物传递系统的研究， 50万元，2020-2021，负责人

    4.广州开发区国际科技合作项目，靶向肿瘤的小干扰核酸药物传递系统研究开发，200万元，2019-2020，子任务负责人

    5.广州市对外科技合作专题，合理的设计和开发信使核糖核酸（mRNA）纳米转染试剂, 100万元，2016-2018，负责人

    社会任职：

    获奖及荣誉：

  • 1、2017年：“珠江人才计划”高层次人才；

    2、2013年：中国自费优秀留学生国家级奖项。

    代表论著：

  • 在高水平杂志发表50余篇论文，累计影响因子380，10篇书章节，主编撰写英文论著一部，申请/授权国内和国际专利共8项。

     

    发表论文（(#Join first co-author）

    1.       Wu LP, Ficker M, Christensen JB, Simberg，D Trohopoulos PN, Moghimi SM*.(2021).  Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking. Nature Communications, 12, 4858.

    2.       Deng W, Zhang Y, Wang W, Song A, Mukama O, Huang J, Han X, Deng S, Lin Z, Habimana JD, Huang R, Peng K, Ni B, Zhang S, Yan X, Li J, Wu LP*, Li Z*.(2021) Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle. Stem Cell Research & Therapy,12, 548

    3.       Pannuzzo M#, Esposito S#, Wu LP#, Key J, Aryal S, Celia C, Marzio LD, Moghimi SM*, Decuzzi P*.(2020)  Overcoming nanoparticle-mediated complement activation by surface PEG-pairing. Nano letters, 20: 4312-4321.

    4.       Wu LP*, Ahmadvand D, Su JA, Hall A, Tan XL, Farhangrazi AZ, Moghimi SM*.(2019).  Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide. Nature Communications, 10, 4635.

    5.       Wu LP*, Wang DY, Li ZB. (2020). Grand challenges in nanomedicine. Materials Science and Engineering C, 106, 110302.

    6.       Xu Z, Wang D, Cheng Y, Yang M, Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.

    7.       Wu LP, Ficker M, Mejls？e SL, Hall A, Paolucci V, Christensen JB, Trohopoulos PN, Moghimi SM*. (2017). Poly-(amidoamine) dendrimers with a precisely core positioned sulforhodamine B molecule for comparative biological tracing and profiling. Journal of Controlled Release, 246, 88-97.

    8.       Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.

    9.       Wu LP, Uldahl KB, Chen FF, Benasutti H, Logvinski D, Vu V,. Banda NK, Peng X, Simberg D, Moghimi SM*. (2017) .Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. Molecular Immunology, 90:273-279.

    10.    Wu LP*, Moghimi SM. (2016) A nanoengineered peptidic delivery system with specificity for human brain capillary endothelial cells. Nanomedicine: NBM, 12(2), 474-475.

    11.    Han J#, Wu LP#, Hou J, Zhao D, Xiang H*. (2015). Biosynthesis, Characterization and Hemostasis Potential of Tailor-Made Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Produced by Haloferax mediterranei. Biomacromolecules，16 (2), 578–588

    12.    Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM*. (2015). Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate chemistry，26(7), 1198-1211.

    13.    Wu LP, Wang DY, Parhamifar L, Hall A, Chen G-Q, Moghimi, SM*. (2014). Poly (3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced healthcare materials, 3(6), 817-824.

    14.    Wu LP#, You ML#, Wang DY, Peng GF, Wang ZH, CHEN G-Q*. (2013). Fabrication of Carbon Nanotubes (CNTs)/ Poly(3-hydroxyburyrate-co-3-hydroxyhexanoate) (PHBHHx) Nanocomposite Films for Human Mesenchymal Stem Cells (hMSCs) Differentiation. Polymer Chemistry, 4, 4490-4498.

    15.    Wu LP#, Tripathi L#, Chen JC, Chen G-Q*. (2012).Synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxy -hexanoate [PHB-b-PHHx] by a beta-oxidation weakened Pseudomonas putida KT2442. Microbial Cell Factories, 11:44.

    16.    Wu LP, Wang XJ, Cheng ST, Xu KT*. (2010). Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone). Acta Biomaterialia, 6, 1079-1089.

    17.    Wu LP, Cheng ST, Li ZB, Chen G-Q*, Xu KT*. (2008). Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)- block-(ε-caprolactone)] triblock copolymers. Polymer International, 57, 939-949.

    18.    Kim HS, Chen JY, Wu LP, Wu JH, Xiang H*, Leong KW, Han J*. (2020)  Prevention of excessive scar formation using nanofibrous meshes made of biodegradable elastomer poly(3-hydroxybutyrate- co-3-hydroxyvalerate). Journal of Tissue Engineering, 11, 1–12.

    19.    Xu Z, Wang D, Cheng Y, Yang M, 2.     Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.

    20.    Hall A , Maynard S, Wu LP, Merchut-Maya JM, Strauss R, Moghimi SM, Bartek J. (2019) Perturbation of mitochondrial bioenergetics by polycations counteracts resistance to BRAFE600 inhibition in melanoma cells. Journal of Controlled Release, 309, 158–172.

    21.    Xue Q, Liu X, Lao YH, Wu LP, Wang D, Zuo Z, Chen J, Hou J, Bei Y, Wu X, Leong KW, Xiang H, Han J*. (2018). Anti-infective biomaterials with surface-decorated tachyplesin I. Biomaterials, 178, 351-362.

    22.    Chen C#, Wang G#, Griffin J, Brenneman B, Banda N, Holers V, Backos D, Wu LP, Moghimi SM, Simberg D*. (2017). Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. Nature Nanotechnology, 12(4), 387-393.

    23.    Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.

    24.    Uldahl KB#, Wu LP#, Hall A, Papathanasiou P, Peng X*, Moghimi SM*. (2017). Recognition of extremophilic archaeal viruses by eukaryotic cells: a promising nanoplatform from the third domain of life. Scientific Reports, 6, 37966. 

    25.    Han J*, Wu LP, Liu XB, Hou J, Zhao LL, Chen JY, Zhao DH, Xiang H*. (2017) Biodegradation and biocompatibility of haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymers. Biomaterials, 139 172-186.

    26.    Ordó？ez-Gutiérrez L, Posado-Fernández A, Ahmadvand D, Lettiero B, Wu LP, Antón, M, Floresc O, Moghimi SM*, Wandosell F*. (2017). ImmunoPEGliposome-mediated reduction of blood and brain amyloid levels in a mouse model of Alzheimer's disease is restricted to aged animals. Biomaterials, 112, 141-152.

    27.    Azmi ID, Wibroe PP, Wu LP, Kazem AI, Amenitsch H, Moghimi S. M*, Yaghmur, A*. (2016). A structurally diverse library of safe-by-design citrem-phospholipid lamellar and non-lamellar liquid crystalline nano-assemblies. Journal of Controlled Release, 239, 1-9.

    28.    Inturi S, Wang G, Chen F, Banda NK, Holers VM, Wu LP, Moghimi SM, Simberg D*. (2015). Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. ACS nano, 9(11), 10758-10768.

    29.    Hall A, Wu LP, Parhamifar L, Moghimi SM*. (2015). Differential modulation of cellular bioenergetics by poly (L-lysine) s of different molecular weights. Biomacromolecules, 16(7), 2119-2126.

    30.    Meng DC, Wang Y, Wu LP, Shen R, Chen JC, Wu Q, Chen G-Q*. (2015). Production of poly (3-hydroxypropionate) and poly (3-hydroxybutyrate-co-3-hydroxypropionate) from glucose by engineering Escherichia coli. Metabolic engineering, 29, 189-195.

    31.    Tripathia L, Wu LP, Meng DC, Chen JC, WU Q, Chen G-Q*. (2013). Pseudomonas putida KT2442 as a platform for the biosynthesis of polyhydroxyalkanoates with adjustable monomer contents and compositions. Bioresource Technology, 142, 225-231.

    32.    Tripathia L, Wu LP, Meng DC, Chen JC, Chen G-Q*. (2013). Biosynthesis and characterization of block copolymer of P(3-Hydroxypropionate)-block-P(4-Hydroxybutyrate) from recombinant escherichia coli. Biomacromolecules, 14, 862–870.

     

    发明专利

    1.    一种核酸递送系统及其制备方法和应用。专利号：2021105723647。

    2.    一种抗疲劳双亲性有机水凝胶及其制备方法和应用。专利号：2021105738657。

    3.    一种多孔聚羟基脂肪酸酯聚合物微球的微流控制备方法及制备得到的多孔聚合物微球及应用。专利号：2021105727347。

    4.    一种抑制sFRP1基因表达的siRNA及其应用。专利号：201811607298.7。

    5.    Peptidic nanodelivery composition targeting two receptors. PCT：PCT/EP2014/067651.

    6.    Nano-systems for therapy and/or diagnosis and/or therapy monitoring and/or theranostics of disease. PCT：PCT/EP2017/060579.