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专家人才

  • 姓名： 杨乐乐
  • 性别： 女
  • 职称： 副研究员
  • 学历： 硕士
  • 电话： 
  • 传真： 
  • 电子邮件: yang_lele@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 1998-09至2002-06，吉林农业大学，动物药学，学士

    2002-09至2005-06，华中农业大学，预防兽医学，硕士

    2005-07至2007-06，中国科学院动物研究所，生物膜与膜生物工程国家重点实验室模式动物与干细胞研究小组，研究实习员

    2007-09至2009-12, 中国科学院广州生物医药与健康研究院, 细胞谱系与发育研究中心, 研究实习员

    2010-01 至 2021-12, 中国科学院广州生物医药与健康研究院, 细胞谱系与发育研究中心, 助理研究员

    2021-12 至 今, 中国科学院广州生物医药与健康研究院, 细胞谱系与发育研究中心, 副研究员

    研究领域：

  • 主要从事小鼠雄性生殖干细胞自我更新与分化的分子调控机制研究。

    承担科研项目情况：

    社会任职：

    获奖及荣誉：

    代表论著：

  • 1.      Lele Yang, Wei Wu, Huayu Qi. Gene expression profiling revealed specific spermatogonial stem cell genes in mouse. Genesis, 2013 Feb; 51(2):83–96.

    2.      Lele Yang#, Dongsheng Chen#, Ranhui Duan#, Laixin Xia, Jun Wang, Abrar Qurashi, Peng Jin*, Dahua Chen*. Argonaute 1 protein regulates the fate of germline stem cell in Drosophila. Development, 2007 Dec; 134(23):4265-4272.

    3.      Lele Yang#, Ranhui Duan#, Dongsheng Chen, Jun Wang, Dahua Chen*, Peng Jin*. Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Human Molecular Genetics , 2007 Aug ;16(15):1814-1820.

    4.      Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi. Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis. iScience. 2021 Dec;24(12):103396.

    5.      Kunyu Shi, Lele Yang, Xueqing Zhuang, Lan Zhang*, and Huayu Qi*. Yeast Two-Hybrid Screen Identifies PKA-Riα Interacting Proteins during Mouse Spermiogenesis. Genes. 2021, Nov 30;12(12), 1941.

    6.      Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee. Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation. PLoS Genetics. 2021 Jul 8;17(7): e1009369.

    7.      Qing Xia, Guizhong Cui, Ye Fan, Xiuqin Wang, Gongcheng Hu, Lisha Wang, Xi Luo, Lele Yang, Qingqing Cai, Kaibiao Xu, Wenjing Guo, Minghui Gao, Yingying Li, Ji Wu, Wei Li, Jiayu Chen, Huayu Qi, Guangdun Peng, Hongjie Yao. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation. 2021 May;54(5): e13000.

    8.      Kaibiao Xu, Lele Yang, Lan Zhang and Huayu Qi. Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility. Development. 2020 Jan;147(2):1-15.

    9.      Zhuxia Zheng, Hongmei Li, Qinfen Zhang, Lele Yang and Huayu Qi.Unequal distribution of 16S mtrRNA at the 2-cell stage regulates cell lineage allocations in mouse embryos. Reproduction, 2016 Apr;151(4) :351–367.

    10.   Xiaoyong Jiang, Laixin Xia, Dongsheng Chen, Yingyue Yang, Haidong Huang, Lele Yang, Qiudong Zhao, Lijun Shen, Jun Wang, Dahua Chen. Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes. Developmental cell, 2008 Apr; 14(4):494-506.