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专家人才

  • 姓名： 张岩
  • 性别： 女
  • 职称： 副研究员
  • 学历： 博士
  • 电话： 020-32218594
  • 传真： 
  • 电子邮件: zhang_yan2012@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 2022年1月-至今         中国科学院广州生物医药与健康研究院   副研究员

    2021年7月-2021年12月 中国科学院广州生物医药与健康研究院   助理研究员

    2019年7月-2021年6月  中国科学院广州生物医药与健康研究院   博士后

    2016年9月-2019年6月  中国科学院广州生物医药与健康研究院   药物化学   博士

    2012年7月-2016年8月  中国科学院广州生物医药与健康研究院   助理研究员

    2009年9月-2012年6月  辽宁师范大学化学系                   物理化学   硕士

    2004年9月-2009年6月  内蒙古民族大学化学化工学院           化学教育   本科

    研究领域：

  • 1. 分子模拟与药物设计

    2. 结构生物学

    3. 药物化学

    承担科研项目情况：

  • 1. 国家自然科学基金青年基金，21602222，201601-201912，24万，主持

    2. 中科院特别研究助理资助项目，201907-202209，60万，主持

    3. 呼吸疾病国家重点实验室自主项目，SKLRD-Z-202018，202001-202212，20万，主持

    4. 中国博士后科学基金面上项目，2020M672857，202004-202106，8万，主持

    5. 广东省自然科学基金面上项目，2020A1515010250，201910-202209，10万，主持

    6. 广州市基础研究计划基础与应用基础研究项目，202102080215，202104-202303，5万，主持

     

    社会任职：

    获奖及荣誉：

  • 2018年度广东省自然科学奖二等奖（第二完成人）

    2019年获得中国科学院特别研究助理称号

    2019年度中国科学院优秀毕业生

    2019年度北京市普通高等学校优秀毕业生

    代表论著：

  • [1]      Zhang, M#.; Luo, X#.; Zhang, C.; Wang, C.; Wu, X.; Xiang, Q.; Xu, Y*.; Zhang, Y*. Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia. Acta Pharmacologica Sinica 2022, doi: 10.1038/s41401-022-00881-y.

    [2]      Wu, T#.; Xiang, Q#.; Wang, C#.; Wu, C.; Zhang, C.; Zhang, M.; Liu, Z.; Zhang, Y*.; Xiao, L*.; Xu Y*. Y06014 is a selective BET inhibitor for the treatment of prostate cancer. Acta Pharmacologica Sinica 2021, 64, 8775-8797.

    [3]      Song, Y.; Xue, X.; Wu, X.; Wang, R.; Xing, Y.; Yan, W.; Zhou, Y.; Qian, C-N.; Zhang, Y.*; Xu, Y.*; Identification of N-phenyl-2-(N-phenylphenylsulfonamido) Acetamides as New RORγ Inverse Agonists: Virtual Screening, Structure-based Optimization, and Biological Evaluation. European Journal of Medicinal Chemistry2016, 116, 13-26.

    [4]      Wu, X#.; Shen, H#.; Zhang, Y#.; Wang, C.; Li, Q.; Zhang, C.; Zhuang, X.; Li, C.; Shi, Y.; Xing, Y.; Xiang, Q.; Xu, J.; Wu, D.; Liu, J.; Xu, Y*.  Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist. Journal of Medicinal Chemistry 2021, 64, 8775-8797.

    [5]      Zhang, Y#.; Wu, X#.; Xue, X#.; Li, C.; Wang, J.; Wang, R.; Zhang, C.; Wang, C.; Shi, Y.; Zou, L.; Li, Q.; Huang, Z.; Hao, X.; Loomes, K.; Wu, D.; Chen, H.; Xu, J.; Xu, Y.* Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. Journal of Medicinal Chemistry 2019, 62, 4716-4730.

    [6]      Zhang, M#.; Zhang, Y#.; Song, M#.; Xue, X.; Wang, J.; Wang, C.; Zhang, C.; Li, C.; Xiang, Q.; Zou, L.; Wu, X.; Wu, C.; Dong, B.; Xue, W.; Zhou, Y.; Chen, H.; Wu, D.; Ding, K.; Xu, Y.* Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). Journal of Medicinal Chemistry 2018. 61, 3037-3058.

    [7]      Xiang, Q#.; Zhang, Y#.; Li, J#.; Xue, X.; Wang, C.; Song, M.; Zhang, Z.; Wang, R.; Li, C.; Wu, C.; Zhou, Y.; Yang, X.; Li, G.; Ding, K.; Xu, Y.* Y08060: A selective BET inhibitor for treatment of prostate cancer. ACS Medicinal Chemistry Letters 2018, 9, 262-267.

    [8]      Xue, X#.; Zhang, Y#.; Liu, Z.; Song, M.; Xing, Y.; Xiang, Q.; Wang, Z.; Tu, Z.; Zhou, Y.; Ding, K.; Xu, Y.* Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation. Journal of Medicinal Chemistry 2016. 59, 1565-1579.

    [9]      Zhang, Y.; Luo, X. Y.; Wu, D. H.*; Xu, Y.* ROR nuclear receptors: structures, related diseases, and drug discovery. Acta Pharmacologica Sinica 2015, 36, 71-87.

    [10]   Zhang, Y#.; Xue, X#.; Jin, X.; Song, Y.; Li, J.; Luo, X.; Song, M.; Yan, W.; Song, H.; Xu, Y.* Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORgamma inhibitors using virtual screening, synthesis and biological evaluation. European Journal of Medicinal Chemistry 2014, 78, 431-441.

    [11]   Li, J#.; Zhang, C#.; Xu, H.; Wang, C.; Dong, R.; Shen, H.; Zhuang, X.; Chen, X.; Li, Q.; Lu, J.; Zhang, M.; Wu, X.; Loomes, KM.; Zhou, Y.; Zhang, Y.; Liu, J.; Xu, Y*. Structure-Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. Journal of Medicinal Chemistry 2022, 65, 5760-5799.

    [12]   Li, W#.; Zhang, C#.; Zhang, H.; Dong, R.; Liu, J.; Wang, C.; Wang, M.; Wang, Y.; Wang, C.; Zhang, Y.; Shi, L.; Xu, Y*.; Sun, L*. Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors. Bioorganic Chemistry 2022, 127, 105917.

    [13]   Xiang, Q#.; Luo, G#.; Zhang, C.; Hu, Q.; Wang, C.; Wu, T.; Xu, H.; Hu, J.; Zhuang, X.; Zhang, M.;Wu, S.; Xu, J.; Zhang, Y.; Liu, J.; Xu, Y*. Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors. European Journal of Medicinal Chemistry 2022, 236, 114311.

    [14]   Xiang, Q#.; Wang, C#.; Wu, T#.; Zhang, C.; Hu, Q.; Luo, G.; Hu, J.; Zhuang, X.; Zou, L.; Shen, H.; Wu, X.; Zhang, Y.; Kong, X.; Liu, J.; Xu, Y*. Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. Journal of Medicinal Chemistry 2022, 65, 785-810.

    [15]   Li, Q#.; Yao, B#.; Zhao, S.; Lu, Z.; Zhang, Y.; Xiang, Q.; Wu, X.; Yu, H.; Zhang, C.; Li, J.; Zhuang, X.; Wu, D.; Li, Y*.; Xu, Y*. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. Journal of Medicinal Chemistry 2022, 65, 7193-7211.

    [16]   Wu, X.; Zhang, Y.; Xu, Y.* Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1) Agonist. Journal of Medicinal Chemistry 2019, 62, 11019-11021.

    [17]   Hu Q.; Wang C.; Xiang Q.; Wang R.; Zhang C.; Zhang M.; Xue X.; Luo G.; Liu X.; Wu X.; Zhang, Y.; Wu, D.; Xu, Y.* Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo [d] isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities. Bioorganic Chemistry 2019, 94, 103424.

    [18]   Peng, L.; Zhang, Z.; Lei, C.; Li, S.; Zhang, Z.; Ren, X.; Chang, Y.; Zhang, Y.; Xu, Y.; Ding, K. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Medicinal Chemistry Letters 2019, 10, 767-772.

    [19]   Zou, L#.； Xiang, Q.; Xue, X.; Zhang, C.; Li, C.; Wang, C.; Li, Q.; Wang, R.; Wu, S.; Zhou, Y.; Zhang, Y.; Xu, Y.* Y08197 is a Novel and Selective CBP and EP300 Bromodomain Inhibitor for Treatment of Prostate Cancer. Acta Pharmacologica Sinica 2019, 40, 1436-1447.

    [20]   Xue, X.; Zhang, Y.; Wang, C.; Zhang, M.; Xiang, Q.; Wang, J.; Wang, A.; Li, C.; Zhang, C.; Zou, L.; Wang, R.; Wu, S.; Lu, Y.; Chen, H.; Ding, K.; Li, G.; Xu, Y.* Benzoxazinone-containing 3,5-Dimethylisoxazole Derivatives as BET Bromodomain Inhibitors for Treatment of Castration-Resistant Prostate Cancer. European Journal of Medicinal Chemistry 2018, 152, 542-559.

    [21]   Xiang, Q#.; Wang, C#.; Zhang, Y.; Xue, X.; Song, M.; Zhang, C.; Li, C.; Wu, C.; Li, K.; Hui, X.; Zhou, Y.; Smaill, JB.; Patterson, AV.; Wu, D.; Ding, K.; Xu, Y.* Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.European Journal of Medicinal Chemistry 2018, 147, 238-252.

    [22]   Li, H.; Zhao, L.; Singh, R.; Ham, JN.; Fadoju, DO.; Bean, LJH.; Zhang, Y.; Xu, Y.; Xu, HE.; Gambello MJ. The First Pediatric Case of Glucagon Receptor Defect Due to Biallelic Mutations in GCGR is Identified by Newborn Screening of Elevated Arginine. Molecular Genetics and Metabolism Reports 2018, 17, 46-52.

    [23]   Wang, J.; Zou, J.X.; Xue, X.; Cai, D.; Zhang, Y.; Duan, Z.; Xiang, Q.; Yang, J.C.; Louie, M.C.; Borowsky, A.D.; Gao, A.C,; Evans, C.P.; Lam, K.S.; Xu, J.; Kung, H.J.; Evans, R.M.; Xu, Y.*; Chen, H.W.* ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nature Medicine 2016, 22, 488-496.

    [24]   Wu, X#.; Wang, R#.; Xing, Y#.; Xue, X.; Zhang, Y.; Lu, Y.; Song, Y.; Luo, X.; Wu, C.; Zhou, Y.; Jiang, J.*; Xu, Y.* Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists. Acta Pharmacologica Sinica 2016, 37, 1516-1524.

    [25]   Zhou, Y#.; Nie, T#.; Zhang, Y.; Song, M.; Li, K.; Ding, M.; Ding, K.; Wu, D.*; Xu, Y.* The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. Bioorganic & Medicinal Chemistry2016, 24, 4310-4317.

    [26]   Chang, Y.; Lu, X.; Shibu, MA.; Dai, YB.; Luo, J.; Zhang, Y.; Li, Y.; Zhao, P.; Zhang, Z.; Xu, Y.; Tu, ZC.; Zhang, QW.; Yun, CH.; Huang, CY.; Ding, K. Structure based design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as selective leucine-zipper and sterile-α motif kinase (ZAK) inhibitors. Journal of Medicinal Chemistry 2017, 60, 5927-5932.

    [27]   Gao, M.; Duan, L.; Luo, J.; Zhang, L.; Lu, X.; Zhang, Y.; Zhang, Z.; Tu, Z.; Xu, Y.; Ren, X.; Ding, K. Discovery and optimization of 3-(2-(Pyrazolo[1,5-a] pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. Journal of Medicinal Chemistry 2013, 56, 3281-3295.

    [28]   Cao, M.; Liu, X.; Zhang, Y.; Xue, X.; Zhou, X. E.; Melcher, K.; Gao, P.; Wang, F.; Zeng, L.; Zhao, Y.; Zhao, Y.; Deng, P.; Zhong, D.; Zhu, J. K.*; Xu, H. E.*; Xu, Y.* An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Research 2013, 23, 1043-1054.