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专家人才

  • 姓名： 李合英
  • 性别： 女
  • 职称： 高级工程师
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: li_heying@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历：

  • 2018.03  至   今：中国科学院广州生物医药与健康研究院，高级工程师

    2016.05  2018.02：中国科学院广州生物医药与健康研究院，工程师

    2011.07－2016.04：华南农业大学，农学院，博士后

    2006.09－2011.06：华南农业大学，生命科学学院，理学博士

    2000.04－2004.06：河南大学，生命科学学院，理学学士

    研究领域：

  • 1.模式动植物发育过程中的超微形态解剖结构变化研究

    2.生物电镜样品制备流程的标准化研究

     

    核心技术平台：

    1.病理组织学检测平台：石蜡切片技术、冰冻切片技术

    2.生物常规电镜制样平台：透射/扫描电镜常规制样技术、半薄/超薄切片技术

    3.生物冷冻扫描电镜制样平台：冷冻扫描电镜制样技术

    4.细胞原位电镜制样平台：细胞原位制样技术

    5.免疫胶体金检测平台：电镜免疫胶体金标记技术

    6.大颗粒物质检测平台：电镜负染技术

    承担科研项目情况：

  • 中科院广州区域中心开放课题“胶体金双重免疫标记技术平台搭建”，2020-2021年，主持

    社会任职：

    获奖及荣誉：

    代表论著：

  • 第一作者论文

    1.       Sun J, Zhu AR, Li HY (equal contribution), Zheng K, Zhuang Z, Chen Z, Shi YX, Zhang ZY, Chen SB, Liu XS et al. Isolation of Infectious SARS-CoV-2 from Urine of a COVID-19 Patient. Emerging Microbes & Infections. 9(1): 991-993. 2020. IF:6.212

    2.       Li HY1, Bai M1, Jiang XS1, Shen RX, Wang HN, Wang HY*, Wu H*. Cytological evidence of BSD2 functioning in both chloroplast division and dimorphic chloroplast formation in maize leaves. BMC Plant Biology. 20: 17, 2020. IF:4.03

    3.       Zhou L, Shen RX, Ma XL, Li HY (equal contribution), Li GS, Liu YG*. Preparation of Rice Plant Genomic DNA for Various Applications. Current Protocols in Plant Biology, Published Online, DOI:10.1002/ cppb.20002. 2016.

    4.   Ji CH, Li HY (equal contribution), Chen LB, Xie M, Wang FP, Chen YL, Liu YG*.A Novel Rice bHLH Transcription Factor, DTD, Acts Coordinately with TDR in Controlling Tapetum Function and Pollen Development.Molecular Plant. 6(5):1715-1718, 2013. IF:6.337

    5.       李合英,吴鸿﹡.春砂仁传粉及其生殖生物学研究进展. 亚热带植物科学, 4:75-78,2012

     

    非第一作者论文

    1.       Zhang X, Chen L, Huang X, Chen H, Cai B, Qin Y, Chen Y, Ou S, Li X, Wu Z, Feng Z, Zeng M, Guo W, Li H, Zhou C, Yu S, Pan M, Liu J, Kang K, Cao S & Pei D. MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin. Stem Cell Reviews and Reports, Published: 04 March 2022. IF:6.692

    2.       Wu Y, Chen K, Li L, Hao Z, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY& Liu X. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death & Differentiation, Published: 25 May 2022. IF:12.067

    3.       Ma K, Han JL, Zhang ZX, Li HY, Zhao YC, Zhu QL, Xie YY, Liu YG, Chen LT.OsEDM2L mediates m6A of EAT1 transcript for proper alternative splicing and polyadenylation regulating rice tapetal degradation. Journal of Integrative Plant Bioligy. https://doi.org/10.1111/jipb.13167. 2021. IF:7.061

    4.       Cheng S, Jin Pan, Li HY, Pei DQ*, Shu XD*. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Frontiers in Pharmacology. 12:740529; 2021. IF:3.845

    5.       Wen HX, Li LX, Zhan LX, Zuo YY, Li KP, Qiu MQ, Li HY, Sun WW, Xu E. Hypoxic Postconditioning Promotes Mitophagy against Transient Global Cerebral Ischemia via PINK1/Parkin-induced mitochondrial ubiquitination in Adult Rats. Cell Death & Disease. 12:630; https://doi.org/10.1038/ s41419-021-03900-8. 2021. IF:6.3

    6.       Wang Q, Xiong Y, Zhang S, Sui Y, Yu C, Liu P, Li HY, Guo W, Gao Y, Przepiorski A, Davidson AJ, Guo M*, Zhang Xiao*. The Dynamics of Metabolic Characterisation in iPSC-Derived Kidney Organoids Differentiation via a Comparative Omics Approach. Frontiers in Genetics. 12:632810. 2021. IF:3.258

    7.       Xu Y, Zhou J, Liu C, Zhang S, Gao F, Guo W, Sun X, Zhang C, Li HY, Rao Z, Qiu S, Zhu Q, Liu X, Guo X, Shao Z, Bai Y, Zhang X*,Quan DP*. Understanding the Role of Tissue-Specific Decellularized Spinal Cord Matrix Hydrogel for Neural Stem/Progenitor Cell Microenvironment Reconstruction and Spinal Cord Injury. Biomaterials. 268:120596. 2021. IF:10.317

    8.       Xiao F, Sun J, Xu Y, Li F, Huang X, Li HY, Zhao J, Huang J, Zhao J*. Infectious SARS-CoV-2 in Feces of Patient with Severe COVID-19. Emerging Infections Diseases. 26(8):1920-1922, 2020. IF:7.185

    9.       Xie XR, Zhang ZX, Zhao Z, Xie YY, Li HY, Ma XL, Liu YG*, Chen LT*. The mitochondrial aldehyde dehydrogenase OsALDH2b negatively regulates tapetum degeneration in rice. Journal of Experimental Botany. 71(9): 2551-2560. 2020. IF:5.47

    10.    Wang PT, Xia JH, Zhang LL, Zhao SY, Li SB, Wang HY, Cheng S, Li HY, Yin WG, Pei DQ*, Shu XD*.  SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis. Cells. 8:1335, DOI:10.3390/ cells8111335, 2019. IF:5.77

    11.    Zhou YS, Long Q, Wu Y, Xiang G, Yang L, Chen KS, Qi JT, Li W, Wu H, Li LP, Wang YF, Li M, Li HY, Tang HT, Bao FX, Liu XG*. Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy. DOI:10.1080/15548627.2019.1634944, 2019. IF:11.059

    12.    Liu XL, Qu LB, Ye XM, Yi CH, Zheng XH, Hao ML, Su W, Yao ZP, Chen PH, Zhang SN, Feng YP, Wang Q, Yan QH, Li PC, Li HY, Li F, Pan WQ, Niu XF, Xu R, Feng LQ* and Chen Li*. Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein. Npj Vaccines. DOI:10.1038/s41541-018-0072-6, 2018. IF:3.143

    13.    Zhu QL, Zeng DC,Yu SZ, Cui CJ, Li JM, Li HY, Chen JY, Zhang RZ, Zhao XC, Chen LT, Liu YG*. From Golden Rice to aSTARice: Bioengineering Astaxanthin Biosynthesis in Rice Endosperm. Molecular Plant. 11(12): 1440-1448, 2018. IF:9.326

    14.    Zhao SY, Xia JH, Wu XH, Zhang LL, Wang PT, Wang HY, Li HY, Wang XS, Chen Y, Li YX, Pei DQ*, Shu XD*. Deficiency in class III PI3-kinase induces epithelial damage and intestinal inflammation in zebrafish. Nature Communications. 9: 2639, DOI: 10.1038/ s41467-018-05105-8, 2018. IF:12.353

    15.    Zhu QL, Yu SZ, Zeng DC, Liu HM, Wang HC, Yang ZH, Xie XR, Shen RX, Tan JT, Li HY, Zhao XC, Zhang QY, Chen YL, Guo JX, Chen LT, Liu YG*. Development of “Purple Endosperm Rice” by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System. Molecular Plant. 10(7): 918-929, 2017. IF:8.827

    16.    Chen X, Yang Q, Li H, Li HY, Hong Y, Pan L, Chen N, Zhu F, Chi X, Zhu W, Chen M, Liu H, Yang Z, Zhang E, Wang T, Zhong N, Wang M, Liu H, Wen S, Li X, Zhou G, Li S, Wu H, Varshney R, Liang X, Yu S. Transcriptome-wide sequencing provides insights into geocarpy in peanut (Arachis hypogaea L.). Plant Biotechnology Journal. 14(5): 1215-1224, 2015. IF:5.752

    17.    Ma XL, Zhang QY, Zhu QL, L u W, Chen Y, Qiu R, Wang B, Yang ZF, Li HY, Lin YR, Xie YY, Shen RX,  Chen SF, Wang Z, Chen YL, Guo JX, Chen LT, Zhao XC, Dong ZC, Liu YG*. A robustCRISPR/Cas9 system for convenient, high-efficiency multiplex genome editing in monocot and dicotplants. Molecular Plant. 8(8): 1274-1284, 2015. IF:6.337

    18.    Luo DP, Xu H, Liu ZL, Guo JX, Li HY, Chen LT, Fang C, Zhang QY, Bai M, Yao N, Wu H, Wu H, Ji CH, Zheng HQ, Chen YL, Ye S, Li XY, Zhao XC, Li RQ, Liu YG*. A Detrimental Mitochondrial-Nuclear Interaction Causes Cytoplasmic Male Sterility in Rice. Nature Genetics. 45:573-577, 2013. IF:29.352

    19.    Chen XP, Zhu W, Azam S, Li HY, Zhu FH, Li HF, Hong YB, Liu HY, Zhang EH, Wu H, Yu SL, Zhuo GY, Li SX, Zhong N, Wen SJ, Li XY, Knapp SJ, Ozias-Akens P, Varshney SK, Liang XQ﹡.Deep sequencing analysis of the transcriptomes of peanut aerial and subterranean young pods identifies candidate genes related to early embryo abortion. Plant Biotechnology Journal. 11(1):115-127, 2013. IF:5.752

    20.    Li HF, Zhu FH, Li HY, Zhu W, Chen XP, Hong YB, Liu HY, Wu H, Liang XQ﹡.Proteomic identification of gravitropic response genes in peanut gynophores.Journal of Proteomics. 93:303-313, 2013. IF:3.888

    21.    Jiang XS, Li HY, Wang T, Peng CL, Wang HY, Wu H﹡, Wang XJ﹡.Gibberellin Indirectly Promotes Chloroplast Biogenesis as a Means to Maintain the Chloroplast Population of Expanded Cells. Plant Journal.72:768-780, 2012. IF: 5.972

    22. Yang QS, He H, Li HY, Tian H, Zhang JJ, Zhai LG, Chen JD, Wu H, Yi GJ,He ZH, Peng XX﹡. NOA1 Functions in a Temperature-Dependent Manner to Regulate Chlorophyll Biosynthesis and Rubisco Formation in Rice. Plos One.6(5):e20015.doi:10.1371/journal. pone. 0020015, 2011. IF:3.234

    23. 白玫,郑萍,李合英,吴鸿﹡.苦槛蓝营养器官的结构特征与有效成分积累关系研究. 华南农业大学学报, 36(6):104-110,2015

    24.    李海芬,李合英,陈小平,洪彦彬,刘海燕,吴鸿,梁炫强﹡.花生果针细胞显微和亚显微结构特征. 热带作物学报, 34(3):501-503,2013