2008.09—2012.06 河南师范大学生命科学学院，生物科学专业学士；

多能性和全能性转换机理

利用全能性细胞构建功能性组织细胞或类器官

1.  作为负责人主持项目

1)   TGFβ信号通路介导的上皮-间质转换在合子基因组激活中的调控研究（国家自然科学基金青年科学基金项目，32200669，30万）

2)   WNT/β-catenin信号通路通过TBX3调节人类原始态多能性（中国博士后科学基金面上资助一等资助，2019M650195，12万）

3)   STELLA介导的DNA被动去甲基化在人类原始态诱导中的功能研究（广州市科技计划项目基础研究计划，2021000122，5万）

2.  作为参与人参加项目：

1)   RNA表观转录修饰及其相关的RNA结合蛋白和蛋白翻译后修饰对人干细胞多能性的调控及分子机制研究（国家重点研发计划2018YFA0106903，项目骨干）

2)   基态多能干细胞的转录延伸调控（国家自然科学基金面上项目31671537）

3)  NANOG在人原始态多能干细胞诱导和维持中的作用机制研究（国家自然科学基金青年基金项目 31601184）

4)   利用干细胞理解和治愈帕金森病（广州再生医学与健康广东省实验室创新团队项目2018GZR110103001）。

1.     Mazid Md. Abdul*^#, Carl Ward^#, Zhiwei Luo^#, Chuanyu Liu^#, Yunpan Li, Yiwei Lai, Liang Wu, Jinxiu Li, Wenqi Jia, Yu Jiang, Hao Liu, Lixin Fu, Yueli Yang, David P. Iba？ez, Junjian Lai, Xiaoyu Wei, Juan An, Pengcheng Guo, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Fei Gao, Junwen Wang, Shahriar Zaman, Baoming Qin, Guangming Wu, Patrick H. Maxwell, Xun Xu, Longqi Liu*, Wenjuan Li*, Miguel A. Esteban* (2022). Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage. Nature 605: 315-324.（影响因子69.5）*Corresponding author, ^#First author.

2.     Qiang Zhuang^#, Wenjuan Li^#, Christina Benda^#, Zhijian Huang, Tanveer Ahmed, Ping Liu, Xiangpeng Guo, David P. Iba？ez, Zhiwei Luo, Meng Zhang, Mazid MD. Abdul, Zhongzhou Yang, Jiayin Yang, Yinghua Huang, Hui Zhang, Dehao Huang, Jianguo Zhou, Xiaofen Zhong, Xihua Zhu, Xiuling Fu, Wenxia Fan, Yulin Liu, Yan Xu, Carl Ward, Muhammad J. Khan, Shahzina Kanwal, Bushra Mirza, Micky D. Tortorella, Hung-Fat Tse, Jiayu Chen, Baoming Qin, Xichen Bao, Shaorong Gao, Andrew P. Hutchins* and Miguel A. Esteban* (2018). "NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming." Nature Cell Biology 20(4): 400-412. (影响因子28.2) *Corresponding author, ^#First author.

3.     Yunpan Li^#, David P. Ibanez, Wenxia Fan, Ping Zhao, Shuhan Chen, Mazid Md. Abdul, Yu Jiang, Lixin Fu, Zhiwei Luo, Zhenhua Liu, Yueli Yang, Jifeng Guo, Giacomo Volpe, Shahzina Kanwal, Dongye Wang, Beisha Tang* and Wenjuan Li* (2020). "Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P)." Stem Cell Research 46: 101845. (影响因子1.6) *Corresponding author, ^#First author.

4.     Zhiwei Luo^#, Xiaobing Qing, Christina Benda, Zhijian Huang, Meng Zhang, Yinghua Huang, Hui Zhang, Lulu Wang, Yiwei Lai, Carl Ward, Giacomo Volpe, Xiaofen Zhong, Baoming Qin, Qiang Zhuang*, Miguel A. Esteban and Wenjuan Li* (2019). "Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming." Cell Regeneration 8(1):21-29. *Corresponding author, ^#First author.

5.     Li Chen, Qiaoqiao Tong, Xiaowen Chen, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang, Wenjuan Li, Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen and Junfeng Ji (2021). "PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus." Nature Communications 12(1): 2829.

6.     Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Liyang Shi, Martha Duttlinger, Jiangping He, Li Sun, Wenjuan Li, Qiang Zhuang, Guoqing Tong, Jon Frampton, Jean-Baptiste Cazier, Jiekai Chen, Ralf Jauch, Miguel A. Esteban and Andrew P. Hutchins (2021). "Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells." Nucleic Acids Research 49(16):9132-9153.

7.     Meng Zhang, Yiwei Lai, Vladislav Krupalnik, Pengcheng Guo, Xiangpeng Guo, Jianguo Zhou, Yan Xu, Zhijun Yu, Longqi Liu, Ao Jiang, Wenjuan Li, Mazid Md. Abdul, Gang Ma, Na Li, Xiuling Fu, Yuan Lv, Mengling Jiang, Muqddas Tariq, Shahzina Kanwal, Hao Liu, Xueting Xu, Hui Zhang, Yinghua Huang, Lulu Wang, Shuhan Chen, Isaac A. Babarinde, Zhiwei Luo, Dongye Wang, Tiantian Zhou, Carl Ward, Minghui He, David P. Iban？ez, Yunpan Li, Jiajian Zhou, Jie Yuan, Yayan Feng, Karthik Arumugam, Umberto Di Vicino, Xichen Bao, Guangming Wu, Axel Schambach, Huating Wang, Hao Sun, Fei Gao, Baoming Qin, Andrew P. Hutchins, Bradley W. Doble, Christine Hartmann, Maria Pia Cosma, Yan Qin, Guo-Liang Xu, Runsheng Chen, Giacomo Volpe, Liang Chen, Jacob H. Hanna and Miguel A. Esteban (2020). "β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus." Science Advances 6(eaba1593): 1-16.

8.     Jiangping He, Xiuling Fu, Meng Zhang, Fangfang He, Wenjuan Li, Mazid Md. Abdul, Jianguo Zhou, Li Sun, Chen Chang, Yuhao Li, He Liu, Kaixin Wu, Isaac A. Babarinde, Qiang Zhuang, Yuin-Han Loh, Jiekai Chen, Miguel A. Esteban and Andrew P. Hutchins (2019). "Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells." Nature Communications 10(1): 34.

9.     Lulu Wang, Xueting Xu, Che Jiang, Gang Ma, Yinghua Huang, Hui Zhang, Yiwei Lai, Ming Wang, Tanveer Ahmed, Runxia Lin, Wenjing Guo, Zhiwei Luo, Wenjuan Li, Meng Zhang, Carl Ward, Minxian Qian, Baohua Liu, Miguel A. Esteban and Baoming Qin (2019). "mTORC1‐PGC1 axis regulates mitochondrial remodeling during reprogramming." The FEBS Journal 287(1):108-121.

10.  Mazid Md Abdul, David P. Ibanez, Ping Zhao, Hao Liu, Xiaofen Zhong, Yingying Li, Meng Zhang, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Xiwei Wang, Wenxia Fan, Zhiwei Luo (2019). "Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson’s disease patient with mutant PINK1 (p. I368N)." Stem Cell Research 41:101607.

11.  Meng Zhang, David P. Ibanez, Wenxia Fan, Hao Liu, Xiaofen Zhong, Xiwei Wang, Yingying Li, Mazid Md.Abdul, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Ping Zhao, Zhiwei Luo (2019). "Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common isoforms abolished." Stem Cell Research 41:101602.

12.  Li Li, Quanjun Zhang, Huaqiang Yang, Qingjian Zou, Chengdan Lai, Fei Jiang, Ping Zhao, Zhiwei Luo, Jiayin Yang, Qian Chen, Yan Wang, Philip N. Newsome, Jon Frampton, Patrick H. Maxwell, Wenjuan Li, Shuhan Chen, Dongye Wang, Tak-Shing Siu, Sidney Tam, Hung-Fat Tse, Baoming Qin, Xichen Bao, Miguel A. Esteban and Liangxue Lai (2017). "Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1." J Biol Chem 292(11): 4755-4763.

13.  Yan Xu, Meng Zhang, Wenjuan Li, Xihua Zhu, Xichen Bao, Baoming Qin, Andrew P. Hutchins and Miguel A. Esteban (2016). "Transcriptional Control of Somatic Cell Reprogramming." Trends Cell Biology 26(4): 272-288.

14.  Longqi Liu, Yan Xu, Minghui He, Meng Zhang, Fenggong Cui, Leina Lu, Mingze Yao, Weihua Tian, Christina Benda, Qiang Zhuang, Zhijian Huang, Wenjuan Li, Xiangchun Li, Ping Zhao, Wenxia Fan, Zhiwei Luo, Yuan Li, Yasong Wu, Andrew P. Hutchins, Dongye Wang, Hung-Fat Tse, Axel Schambach, Jon Frampton, Baoming Qin, Xichen Bao, Hongjie Yao, Biliang Zhang, Hao Sun, Duanqing Pei, Huating Wang, Jun Wang and Miguel A. Esteban (2014). "Transcriptional pause release is a rate-limiting step for somatic cell reprogramming." Cell Stem Cell 15(5): 574-588.  

15.作为共同发明人之一申请国内发明专利三项，专利号ZL201610064508.7（已授权）、202011256758.3、？202211317527.8。

16.作为共同发明人之一申请国际PCT专利两项，专利号：PCT/CN2020/128091、PCT/CN2022/081499。