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专家人才

  • 姓名： Michael Ott
  • 性别： 男
  • 职称： 教授
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: 
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 1980-87 Graduation in Medicine, University of Münster

    1987 M.D., University of Münster

    1987-89 Postgraduate Studies in Molecular Physiology, University of Münster

    1989-93 Resident in Internal Medicine, University Clinic Frankfurt

    1993-1997 Postgraduate Studies, Marion Bessin Liver Research Center, N.Y, USA

    1997-2002 Resident in Internal Medicine and Gastroenterology, Hannover Medical School

    2003 Habilitation (Experimental Cell Therapy for Liver Disease) and “venia legendi” in Internal Medicine, Hannover Medical School

    研究领域：

  • Cell therapies for liver diseases (pre-clinical and clinical); Gene therapy (pre-clinical and clinical); Gene- and base editing; Cellular reprogramming; MicroRNAs; Chronic liver disease; Liver organiods; mRNA –Therapies; Generation of chimeric liver organs

    承担科研项目情况：

  • DFG, BMBF, EU, Industry (~12.5 Mio Euro over the past 10 years)

    社会任职：

  • Co-founder Cytonet GmbH, Germany

    Advisory Board Member, Promethera Biosciences

    获奖及荣誉：

  • 2011-2013 Elected co-director IFB-Transplant Center, Hannover Medical School (MHH)

    2004-2011 Speaker, BMBF- Research Consortium “Mesenchymal Stem Cells”

    2011-2019 Team leader, Rebirth Cluster of Excellence, MHH, Hannover

    2012-2018 Member of the Research Consortium “Ethics of stem cells and genetic engineering”

    Reviewer for Nature Nanomaterials, Nature Medicine, J. of Hepatology, Hepatology, Gastroenterology, etc.

    Independent reviewer/referee for ERC, AFM, DFG, BMBF etc.

    代表论著：

  • 1. Meumann N, Cabanes-Creus M, Ertelt M, Navarro RG, Lucifora J, Yuan Q, Nien-Huber K, Abdelrahman A, Vu XK, Zhang L, Franke AC, Schmithals C, Piiper A, Vogt A, Gonzalez-Carmona M, Frueh JT, Ullrich E, Meuleman P, Talbot SR, Odenthal M, Ott M, Seifried E, Schoeder CT, Schw？ble J, Lisowski L, Büning H. Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy. Hepatology. 2023 Mar 1;77(3):802-815.

    2. Rovai A, Chung B, Hu Q, Hook S, Yuan Q, Kempf T, Schmidt F, Grimm D, Talbot SR, Steinbrück L, G？tting J, Bohne J, Krooss SA, Ott M. In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice. Nat Commun. 2022 Sep 5;13(1):5215.

    3. Yang T, Poenisch M, Khanal R, Hu Q, Dai Z, Li R, Song G, Yuan Q, Yao Q, Shen X, Taubert R, Engel B, Jaeckel E, Vogel A, Falk CS, Schambach A, Gerovska D, Araúzo-Bravo MJ, Vondran FWR, Cantz T, Horscroft N, Balakrishnan A, Chevessier F, Ott M, Sharma AD. Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model. J Hepatol. 2021 Dec;75(6):1420-1433.

    4. Arnold F, Mahaddalkar PU, Kraus JM, Zhong X, Bergmann W, Srinivasan D, Gout J, Roger E, Beutel A, Zizer E, Tharehalli U, Daiss N, Russell R, Perkhofer L, Oellinger R, Lin Q, Hohwieler M, Heller S, Azoitei N, Weiss FU, Lerch MM, Liebau S, Katz S, Lechel A, Rad R, Rudolph KL, Seufferlein T, Kestler HA, Ott M, Sharma A, Hermann PC, Kleger A. Functional genomic screening during somatic cell reprogramming identifies DKK3 as a roadblock of organ regeneration. Adv Sci 2021 May 13;8(14):2100626.

    5. Krooss S, Werwitzke S, Kopp J, Rovai A, Varnholt D, Wachs AS, Goyenvalle A, Aarstma-Rus A, Ott M, Tiede A, Langemeier J, Bohne J. Pathological mechanism and antisense oligonucleotide-mediated rescue of a non-coding variant suppressing factor 9 RNA biogenesis leading to hemophilia B.PLoS Genet. 2020 Apr 8;16(4)

    6. Dai Z, Ott M, Sharma AD. Equal opportunity offer for all hepatocytes. J Hepatol. 2020 Jul;73(1):6-8.

    7. Fráguas-Eggenschwiler M, Eggenschwiler R, S？llner JH, Cortnumme L, Vondran FWR, Cantz T, Ott M, Niemann H. Direct conversion of porcine primary fibroblasts into hepatocyte-like cells. Sci Rep. 2021 Apr 29;11(1):9334.

    8. MicroRNA-125b-5p Regulates Hepatocyte Proliferation During the Termination Phase of Liver Regeneration. Yang D, Dai Z, Yang T, Balakrishnan A, Yuan Q, Vondran FWR, Manns MP, Ott M, Cantz T, Sharma AD.