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专家人才

  • 姓名: Robert Weinkove
  • 性别: 男
  • 职称: 教授
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: rweinkove@malaghan.org.nz
  • 通讯地址 广州市黄埔区开源大道190号

    简历:

  • 教育经历:

    1996年,剑桥大学 克莱尔学院,文学学士

    1999年,伦敦大学 伦敦国王学院,医学学士和外科学士

    2010-2013年,奥塔哥大学,医学博士

    工作经历:

    2018-至今  马拉格汉医学研究中心 临床主任

    2012-至今  首都和海岸区卫生局  血液学家顾问

    2012-2018  马拉格汉医学研究中心 临床研究员

    2011  伦敦盖伊/圣托马斯医院  血液学登记员

    2007-2010  马拉格汉医学研究中心 临床研究员

    2004-2007  伦敦盖伊/圣托马斯医院  血液学登记员

    2003-2004  伦敦圣乔治医院高级医务官

    2003年 圣詹姆斯大学利兹医院 重症监护病房医生

    2002  伦敦盖伊/圣托马斯医院 医务高级干事

    2001-2002  汉诺威医学院 住院医生

    1999-2000  伦敦盖伊/圣托马斯医院  医学与泌尿泌尿外科医生

    1999  伦敦格林尼治地区医院 外科主任

     

    研究领域:

  • 癌症免疫治疗的临床研究、血液肿瘤(主要为B细胞白血病和淋巴瘤)的诊断和管理。

    承担科研项目情况:

  • 1.       已完成了新西兰健康协会HRC资助的一项可行性试验一项对乙酰氨基酚在发热性中性粒细胞减少症作用的随机安慰剂对照试验,担任HRC资助的1/2MELVAC试验的临床顾问,该试验主要研究MIMR制造的自体细胞疫苗治疗晚期黑色素瘤患者。

    2.       承担了China-MWC项目:项目名称:New methods to improve CAR T cell therapy for cancer(提升CAR T细胞抗肿瘤效果的新策略);项目负责人:Rachel Perret, Robert Weinkove,参与人:Peng Li(李鹏), Le Qin(秦乐,;资助金额:492946新币;项目执行期:2021.09-2023.08

    3.       与李鹏组联合开展了国家自然科学基金课题国际(地区)合作交流项目。项目名称:含TLR共刺激结构域的嵌合抗原受体T细胞的优化及其抗肿瘤机制研究(项目编号:81961128003),资助直接经费300万元,执行期间2019.07.01-2022.06.31

    4.       与李鹏组联合开展了广州市对外科技合作项目,项目名称:研发新型靶向恶性肿瘤并逆转肿瘤微环境的细胞免疫治疗(项目编号:201907010042),资助经费200万元,执行周期2019.04.01-2022.03.31

    社会任职:

  • 2019 新西兰卫生研究理事会生物医学研究委员会成员

    2019 ENABLE试验管理委员会主席

    2019 REDDS-2试验数据安全检测委员会主席

    获奖及荣誉:

  • 2019 新西兰卫生研究理事会 临床医生研究奖学金

    201810 荣获马拉格汉医学研究中心临床医生研究奖学金

    201211 荣获奥塔哥大学临床研究博士奖

    代表论著:

  • 1.        Burn OK, Farrand K, Pritchard T, Draper S, Tang CW, Mooney AH, Schmidt AJ, Yang SH, Williams GM, Brimble MA, Kandasamy M, Marshall AJ, Clarke K, Painter GF, Hermans IF, Weinkove R. Glycolipid-peptide conjugate vaccines elicit CD8+ T-cell responses and prevent breast cancer metastasis. Clin Transl Immunology. 2022 Jul 3;11(7):e1401.

    2.        Jarvis EM, Collings S, Authier-Hall A, Dasyam N, Luey B, Nacey J, Painter GF, Delahunt B, Hermans IF, Weinkove R. Mucosal-Associated Invariant T (MAIT) Cell Dysfunction and PD-1 Expression in Prostate Cancer: Implications for Immunotherapy. Front Immunol. 2021 Oct 19;12:748741.

    3.        Weinkove R, George P, Ruka M, Haira TH, Giunti G. Chimeric antigen receptor T-cells in New Zealand: challenges and opportunities. N Z Med J. 2021 Sep 17;134(1542):96-108.

    4.        McQuilten ZK, Busija L, Seymour JF, Stanworth S, Wood EM, Kenealy M, Weinkove R; Australasian Leukaemia and Lymphoma Group (ALLG). Hemoglobin is a key determinant of quality of life before and during azacitidine-based therapy for myelodysplasia and low blast count acute myeloid leukemia. Leuk Lymphoma. 2022 Mar;63(3):676-683.

    5.        Weinkove R, McQuilten Z, Adler J, Agar M, Blyth E, Cheng A, Conyers R, Haeusler G, Hardie C, Jackson C, Lane S, Middlemiss T, Mollee P, Mulligan S, Ritchie D, Ruka M, Solomon B, Szer J, Thursky K, Wood E, Worth L, Yong M, Slavin M, Teh B. Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance. Med. J. Aust. 2020; 212: 481-9.

    6.        George P, Brown A & Weinkove R. B-cell prolymphocytic leukemia with a t(4;14) FGFR3/IGH translocation: response to ibrutinib. Pathology 2020; 52: 491 2.

    7.        Grasso G, Field CS, Tang C-W, Ferguson PM, Compton BJ, Anderson RJ, Painter GF, Weinkove R, Hermans IF, Berridge MV. Vaccines adjuvanted with an NKT cell agonist induce effective T-cell responses in models of CNS lymphoma. Immunotherapy 2020; 12: 395 406

    8.        Dasyam N, George P, Weinkove R. Chimeric antigen receptor T-cell therapies: Optimising the dose. Br J Clin Pharm 2020; 86: 1678 89

    9.        George P, Dasyam N, Giunti G, Mester B, Bauer E, Andrews B, Perera T, Ostapowicz T, Frampton C, Li P, Ritchie D, Bollard CM, Hermans IF, Weinkove R. Third-generation anti-CD19 chimeric antigen receptor T-cells incorporating a TLR2 domain for relapsed or refractory B-cell lymphoma: a phase I clinical trial protocol (ENABLE). BMJ Open 2020;10:e034629

    10.     Dickinson M, Weinkove R. Maintaining a fit T-cell compartment: lymphoma treatment sequencing in the era of CAR T-cell therapies. Int Med J 2019; 49: 1338.

    11.     Weinkove R, George P, Dasyam N, McLellan A. Selecting costimulatory domains for chimeric antigen rceptors: functional and clinical considerations. Clin Transl Immunology 2019; 8: e1049

    12.     Weinkove R, Bowden E, Wood C, Campion V, Carter J, Hall R, Weatherall M, Beasley R, Young P. A randomised controlled feasibility trial of paracetamol during febrile neutropenia in hemato-oncology patients. Leukemia & Lymphoma 2019; 60: 1540-7

    13.     Wheeler M, White G, Brockie S, Dickson M, Weinkove R. Flow cytometric analysis of mechanically disaggregated bone marrow trephine biopsies. Cytometry B Clin Cytom 2018; 27: 120-6.

    14.     Speir M, Authier-Hall A, Brooks CR, Farrand KJ, Compton BJ, Anderson RJ, Heiser A, Osmond TL, Tang CW, Berzofsky JA, Terabe M, Painter GF, Hermans IF, Weinkove R. Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins. Sci Rep. 2017; 7: 14273.

    15.     Fischer K, Al-Sawaf O, Fink A, Dixon M, Bahlo J, Warburton S, Kipps TK, Weinkove R et al. Venetoclax and obinutuzumab in chronic lymphocytic leukemia. Blood 2017; 129: 2702-5.

    16.     Speir M, Hermans IH, Weinkove R. Engaging natural killer T cells as universal helpers for vaccination. Drugs 2017; 7: 1-15.

    17.     Lucas N, Humble M, Sim D, Balm M, Carter JM, Weinkove R. Temporal changes in neutropenic blood culture isolates and disease associations: a single centre series of 1139 episodes. Int Med J 2017; 47: 962-5.

    18.     Mo A, McQuilten Z, Wood E, Weinkove R. Red cell transfusion thresholds in myelodysplastic syndromes: A clinician survey to inform future clinical trials. Int Med J 2017; 47: 695-8.