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专家人才

  • 姓名： 单永礼
  • 性别： 男
  • 职称： 副研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: shan_yongli@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 2008.09-2012.06  安徽大学  生物科学  学士

    2012.09-2018.01  中国科学院广州生物医药与健康研究院  细胞生物学  博士

    2018.01-2018.08  中国科学院广州生物医药与健康研究院  助理研究员

    2018.09-2021.01  南方医科大学南方医院                博士后

    2021.01 至今    中国科学院广州生物医药与健康研究院  副研究员

    研究领域：

  • 1. 人多能干细胞干性维持与谱系分化的研究

    2. 人胎盘发育及胎盘疾病建模研究。

    承担科研项目情况：

  • 1. 国家自然科学基金面上项目（2022）

    2. 国家自然科学基金青年项目（2018）

    3. 中国博士后科学基金面上项目（2019）

    4. 广东省自然科学基金面上项目（2020）

    5. 广州市科技计划项目科学研究计划一般项目（2019）

    社会任职：

    获奖及荣誉：

    代表论著：

  • 1. Wei Yanxing, Wang Tianyu, Ma Lishi, Zhang Yanqi, Zhao Yuan, Lye Kathryn, Xiao Lu, Chen Chunlin, Wang Zhijian, Ma Yanlin, Zhou Xiaohua, Sun Fei, Li Weili, Dunk Caroline, Li Siliang, Nagy Andras, Yu Yanhong, Pan Guangjin*, Lye J Stephen*, Shan Yongli*. Efficient Derivation of Human Trophoblast Stem Cells from Primed Pluripotent Stem Cells. Science Advances, 2021, 7: eabf4416.

    2. Shan Yongli#, Zhang Yanqi#, Zhao Yuan#, Wang Tianyu, Zhang Jingyuan, Yao Jiao, Ma Ning, Liang Zechuan, Huang Wenhao, Huang Ke, Zhang Tian, Su Zhenghui, Chen Qianyu, Zhu Yanling, Wu Chuman, Zhou Tiancheng, Sun Wei, Wei Yanxing, Zhang Cong, Li Chenxu, Su Shuquan, Liao Baojian, Zhong Mei, Zhong Xiaofen, Nie Jinfu, Pei Duanqing, Pan Guangjin*. JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells. Nature Communications, 2020, 11 (1): 382.

    3. Shan Yongli#, Liang Zechuan#, Xing Qi, Zhang Tian, Wang Bo, Tian Shulan, Huang Wenhao, Zhang Yanqi, Yao Jiao, Zhu Yanling, Huang Ke, Liu Yujian, Wang Xiaoshan, Chen Qianyu, Zhang Jian, Shang Bizhi, Li Shengbiao, Shi Xi, Liao Baojian, Zhang Cong, Lai Keyu, Zhong Xiaofen, Shu Xiaodong, Wang Jinyong, Yao Hongjie, Chen Jiekai, Pei Duanqing and Pan Guangjin*. (2017). PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naive ESCs. Nature Communications 8: 672.

    4. Wei Yanxing#, Xiao Lu#, Ma Lishi, Wang Zhijian, Huang Liping, Li Huiying, Pan Guangjin, Lye J. Stephen, Shan Yongli*. Protocol to derive human trophoblast stem cells directly from primed pluripotent stem cells. STAR Protocols, 2022, 3: 101638.

    5. Long Bong#, Shan Yongli#, Sun Yanling#, Wang Tianyu, Li Xudong, Huang Ke, Zhang Wenwen, He Yi, Wen Ruijuan, Li Yuhang, Mai Yuchan, Feng Yashu, Zhang Tian, Kang Baoqiang, Zhang Cong, Zhu Yanling, Gu Jiaming, Liu Jiajun, Zhang Xiangzhong*, Pan Guangjin*. Vitamin C promotes anti-leukemia of DZNep in acute myeloid leukemia. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2022, 1868: 166357. 

    6. Zhao Yuan#, Wang Tianyu#, Zhang Yanqi#, Shi Liang, Zhang Cong, Zhang Jingyuan, Yao Jiao, Chen Qianyu, Zhong Xiaofen, Wei Yanxing, Shan Yongli*, Pan Guangjin*. Coordination of EZH2 and SOX2 specifies human neural fate decision. Cell Regeneration, 2021, 10: 30. 

    7. Xiao Lu#, Ma Lishi#, Wang Zhijian, Yu Yanhong, Lye J. Stephen, Shan Yongli*, Wei Yanxing*. Deciphering a distinct regulatory network of TEAD4, CDX2 and GATA3 in humans for trophoblast transition from embryonic stem cells. Biochimica et Biophysica Acta - Molecular Cell Research, 2020, 1867: 118736.

    8. Ma Ning#, Shan Yongli#, Liao Baojian#, Kong Guanyi#, Wang Cheng, Huang Ke, Zhang Hui, Cai Xiujuan, Chen Shubin, Pei Duanqing, Chen Nansheng*, Pan Guangjin*. Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in beta-Thalassemia Induced Pluripotent Stem Cells (iPSCs). Journal of Biological Chemisrty, 2015, 290(19):12079-89.