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专家人才

  • 姓名: 刘劲松
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: liu_jinsong@gibh.ac.cn
  • 通讯地址 广州萝岗区科学城开源大道190号

    简历:

  • 1988-6/1992 北京大学 学士

    1994-1/2000 美国罗格斯大学 (Rutgers University) 博士

    2000 - 2/2000 美国罗格斯大学 (Rutgers University) 博士后

    2000 - 8/2004 美国 Tularik 公司,科学家 , 助理科学家 , 资深研究助理

    2004 - 10/2005 美国 Amgen 公司,资深科学家

    2005 - 现在 中国科学院广州生物医药与健康研究院,研究员

    研究领域:

  • 以结构生物学为主要手段,紧密结合新药研发,着眼于与人类重大疾病和重要生理功能相关的蛋白质及其复合体的结构与功能的关系,阐明生物大分子与小分子化合物在结构与功能方面的分子作用机理,为药物的分子设计提供思路;同时,通过解析生物大分子及其复合物的三维结构,为药物设计提供一个分子水平上的模板

    承担科研项目情况:

  • 1. 国家重点研发计划(2017年),项目负责人。

    2. 97320122005),项目负责人。

    3. 国家自然科学基金面上项目(2018年、2016年、2012年、2009年),项目负责人。

    4. 国家自然科学基金联合基金项目(2013年),项目负责人。

    5. 广东省自然科学基金团队项目(2015),项目负责人。

    6. 广州市健康医疗协同创新重大专项(2014,项目负责人。

    社会任职:

  • 呼吸疾病国家重点实验室  副主任

    广东省生物医药计算重点实验室 副主任

    获奖及荣誉:

  •  

    代表论著:

  •  1.     Xu T.*, Gan Q., Wu B., Yin M., Xu J., Shu X., Liu J.*. Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. J Mol Biol 2020, 432(16): 4750-4761.

    2.     Xu J.#*, Tang X.#, Zhu Y., Yu Z., Su K., Zhang Y., Dong Y., Zhu W., Zhang C., Wu R., Liu J.*. Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Commun Biol 2020, 3(1): 455.

    3.    Makafe, G. G.#, Hussain, M.#, Surineni, G., Tan, Y., Wong, N. K., Julius, M., Liu, L., Gift, C., Jiang, H., Tang, Y., Liu, J., Tan, S., Yu, Z., Liu, Z., Lu, Z., Fang, C., Zhou, Y., Zhang, J., Zhu, Q., Liu, J.* and Zhang, T.* Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase. Cell Chem Biol 2019, 26, 1187-1194 e1185

    4.     Hussain, M.#, Adah, D.#, Tariq, M., Lu, Y., Zhang, J.* and Liu, J.* CXCL13/CXCR5 signaling axis in cancer. Life Sci 2019, 227, 175-186

    5.     Xu T, Zhou CZ, Xiao J.*, Liu J.* Unique Conformation in a Natural Interruption Sequence of Type XIX Collagen Revealed by Its High-Resolution Crystal Structure. Biochemistry 2018, 57(7): 1087-1095

    6.     Wang N, Zou Q, Xu J, Zhang J, Liu J.* Ligand binding and heterodimerization with retinoid X receptor alpha (RXRalpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding. The Journal of biological chemistry 2018, 293(47): 18180-18191

    7.     Xu T., Xie C., Yao D., Zhou CZ., Liu J.*. Crystal structures of Aflatoxin-oxidase from Armillariella tabescens reveal a dual activity enzyme. Biochemical and biophysical research communications 2017, 494(3-4): 621-625

    8.     Xu J#, Zhang L#, Ye Y, Shan Y, Wan C, Wang J, Pei D, Shu X.*, Liu J.* SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure 2017, 25(8): 1251-1263 e1255

    9.     Hou S, Xu T, Xu J, Qu L, Xu Y, Chen L, Liu J*. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE. Scientific reports 2017, 7(1): 10815

    10.   Zhu Y#, Xu J#, Mei X#, Feng Z, Zhang L, Zhang Q, Zhang G, Zhu W*, Liu J*, Zhang C*. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS chemical biology 2016, 11(4): 943-952

    11.   Hussain M, Lu Y, Liu YQ, Su K, Zhang J, Liu J*, Zhou GB*. Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery. Pharmacological research 2016, 111: 34-42

    12.   Zhu L, Yang J, Li H, Sun H, Liu J*, Wang J*. Conformational change study of dengue virus NS2B-NS3 protease using (19)F NMR spectroscopy. Biochemical and biophysical research communications 2015, 461(4): 677-680

    13.  Liu YQ#, Wang XL#, Cheng X#, Lu YZ#, Wang GZ#, Li XC, Zhang J, Wen ZS, Huang ZL, Gao QL, Yang LN, Cheng YX*, Tao SC, Liu J *, Zhou GB*. Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget 2015, 6(33): 34953-34967

    14.   Guo S#, Xu J#, Pavlidis IV, Lan D, Bornscheuer UT, Liu J*, Wang Y*. Structure of product-bound SMG1 lipase: active site gating implications. The FEBS journal 2015, 282(23), 4538-4547

    15.   Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J*. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 2014, 82(12): 3483-3489

    16.   Mei G, Dong J, Li Z, Liu S, Liu Y, Sun M, Liu G, Su Z*, Liu J*. Structural basis for the immunomodulatory function of cysteine protease inhibitor from human roundworm Ascaris lumbricoides. PloS one 2014, 9(4): e96069

    17.   Li H, Zhu L, Hou S, Yang J, Wang J*, Liu J*. An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease. FEBS letters 2014, 588(17): 2794-2799

    18.   Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J*. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. The Journal of biological chemistry 2013, 288(23): 16598-16605

    19.   Xu T#, Liu L#, Hou S, Xu J, Yang B, Wang Y*, Liu J*. Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. J Struct Biol 2012, 178(3): 363-369

    20.  Liu J#, Sudom A#, Min X#, Cao Z, Gao X, Ayres M, Lee F, Cao P, Johnstone S, Plotnikova O, Walker N, Chen G, Wang Z. Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. The Journal of biological chemistry 2012, 287(33): 27326-27334

    21.   Bi Y, Zhu L, Li H, Wu B, Liu J*, Wang J*. Backbone (1)H, (13)C and (15)N resonance assignments of dengue virus NS2B-NS3p in complex with aprotinin. Biomol NMR Assign 2012, 7:137-139

    22.   Zhang Y, Xu T, Chen Q, Wang B, Liu J*. Expression, purification, and refolding of active human and mouse secreted group IIE phospholipase A. Protein Expr Purif 2011, 80(1): 68-73

    23.   Wang Y, Wang Q, Zhu Q, Zhou R, Liu J*, Peng T*. Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children. J Clin Virol 2011, 52(2): 107-112

    24.   Lu N, Wang W, Liu J*, Wong CW*. Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha. Cell Signal 2011, 23(9): 1473-1478

    25.   Liu S, Dong J, Mei G, Liu G, Xu W, Su Z, Liu J*. Crystallization and preliminary crystallographic studies of a cysteine protease inhibitor from the human nematode parasite Ascaris lumbricoides. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 2): 228-230

    26.   Liu Q, Shen Y, Liu S, Weng J, Liu J*. Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site. FEBS letters 2011, 585(8): 1175-1179

    27.   Gong L, Xiao Y, Liu Q, Li S, Zhang C, Liu J*. Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 1): 136-139

    28.   Gao M#, Wang J#, Lu N#, Fang F, Liu J*, Wong CW*. Mitogen-activated protein kinase kinases promote mitochondrial biogenesis in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression. Biochimica et biophysica acta 2011, 1813(6): 1239-1244

    29.   Xu W#, Yi L#, Feng Y, Chen L*, Liu J*. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. The Journal of biological chemistry 2009, 284(24): 16659-16666.

    30. Bella J#, Liu J#, Kramer R, Brodsky B, Berman HM*. Conformational effects of gly-x-gly interruptions in the collagen triple helix. J Mol Biol 2006, 362(2): 298-311.

    30.   Wang Z#, Benoit G#, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP*, Perlmann T*. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 2003, 423(6939): 555-560.

    31.   Benoff B, Yang H, Lawson CL, Parkinson G, Liu J, Blatter E, Ebright YW, Berman HM*, Ebright RH*. Structural basis of transcription activation: the CAP-alpha CTD-DNA complex. Science 2002, 297(5586): 1562-1566.

    32.   Liu J, Lynch PA, Chien CY, Montelione GT, Krug RM, Berman HM*. Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol 1997, 4(11): 896-899.