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专家人才

  • 姓名: 李志远
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: li_zhiyuan@gibh.ac.cn
  • 通讯地址 广州萝岗区科学城开源大道190号

    简历:

    • 1997年获中南大学药理学博士学位,并赴日留学
      2000年获得日本德岛大学(Tokushima University)博士学位

    • 2000-2002年 在美国范德堡大学(Vanderbilt University)药理学系从事博士后研究
      2002-2007年 在美国圣路易斯大学(Saint Louis University)医学院从事研究工作,担任助理教授
       

    研究领域:

    • 细胞膜离子通道蛋白的研究

    •  P2X受体的结构与功能研究

    • 干细胞的神经分化与电生理研究 

    承担科研项目情况:

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    社会任职:

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    获奖及荣誉:

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    代表论著:

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      Deng S, Hou G, Xue Z, Zhang L, Zhou Y, Liu C, Liu Y, Li Z *, Vitamin E isomer -tocopherol enhances the ef?ciency of neural stem cell differentiation via L-type calcium channel, Neuroscience Letters. (2014) 585C:166-170. 

      Jie Y, Zhang L, Xu H, Gao C, Ma W, Li Z, Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement. Neurosci Lett. (2014) 582C:1-5. 

      Zhang L, Xu H, Jie Y, Gao C, Chen W, Yin S, Samways DS, Li Z, Involvement of Ectodomain Leu 214 in ATP Binding and Channel Desensitization of the P2X4 Receptor. Biochemistry. (2014) 53(18): 3012-3019. 

      Chen W, Liu J, Zhang L, Xu H, Guo X, Deng S, Liu L, Yu D, Chen Y, Li Z, Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique. Scientific Reports. . (2014) 4:5404. 

      Long Y, Chen W, Lin Z, Sun H, Xia M, Zheng W, Li Z, Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol. . (2014) 737C: 202-209. 

      Samways DS, Li Z, Egan TM. Principles and properties of ion flow in P2X receptors. Front Cell Neurosci. (2014) 8: 6 

       ·Liang X, Xu H, Xu T, Liu J, Li Z. Identification of an Intrasubunit Interaction between His33 and Ser345 in the Rat P2X2 Receptor. PloS One (2013) 6;8(8): e70629. doi: 10.1371/journal.pone.0070629. 

      ·Li C, Long Y, Lin Z, Jie Y, Xiao Y, Yang L, Sun J, Ren Y, Chen L, Li Z.New strategy for high throughput screening of anti-influenza virus m2 ion channel inhibitors. Current Pharmacology Design. (2013) 19 (28): 5146-55. 

      ·Long Y, Lin Z, Xia M, Zheng W,LiZ. Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride. Toxicology and Applied Pharmacology 267 (2013) 155166. 

      ·Samways DS, Migita K, Li Z, Egan TM. Principles and properties of ion flow in P2X receptors. (2013) Frontiers in Cellular Neuroscience. 8f16-ede35c613a45.  

      ·Su H, Wang L, CaiJ, Yuan Q, Yang X, Yao X, Wong W, Huang W, Li Z, Wan J, Wang Y, Pei P, So K, Qin D, Wu W.Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle. (2013) Stem Cell Research11, 529539 

      ·Hu X, Chen D, Cui Y, Li Z, Huang J. Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10. (2013) Scientific Reports. Dec 5;3:3423doi: 10.1038/srep03423. 

      ·Pan A, Li M, Gao J, Xue Z, Li Z,Yuan X, Luo D, Luo X, Yan X. Experimental Epidural Hematoma Causes Cerebral Infarction and Activates Neocortical Glial and Neuronal Genesis in Adult Guinea Pigs. (2013) Journal of neuroscience research, 91(2): 249-261. 

      ·Lu D, He L, Xiang W, Ai W, Cao Y,Wang X, Pan A, Luo X, Li Z, Yan X. Somal and Dendritic Development of Human CA3 Pyramidal Neurons From Midgestation to Middle Childhood: A Quantitative Golgi Study. (2013) The Anatomical Record, 296(1): 123-132. 

      ·Su H, Wang L, Huang W, Qin D, CaiJ, Yao X, FengC, Li Z, Wang Y, So K, Pan G, Wu W, Pei D.Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. (2013) Stem Cell Research10, 338348