专家人才
- 姓名: 吴东海
- 性别: 男
- 职称: 研究员
- 学历: 博士
- 电话:
- 传真:
- 电子邮件: wu_donghai@gibh.ac.cn
- 通讯地址 广州萝岗区科学城开源大道190号
- 1980 – 1984 北京师范大学生物系学士
1985 – 1990 美国德州西南医学中心生物化学与分子生物学博士
- 1990 – 1992 美国德州西南医学中心生物化学系,博士后
1992 – 1994 美国肯塔基大学生物化学系,助理研究教授
1994 – 1998 美国肯塔基大学生物化学系,助理教授
1998 – 2004 美国佛罗里达大学药学院药物化学系,助理教授
2004 – 至今 中国科学院广州生物医药与健康研究院,研究员
- 1980 – 1984 北京师范大学生物系学士
简历:
研究领域:
- 2004CB720102 973计划 与疾病相关抗体的结构与功能研究
- 30670457 国家自然科学基金 肉碱棕榈酰转移酶1c的功能研究
- 30710527 国家自然科学基金国际合作项目 肉碱棕榈酰转移酶1c对脂肪细胞因子的调控研究
- 30810099 国家自然科学基金国际合作项目 APPL1介导脂联素心脏保护作用的功能研究
- 2007Z2-E4021 广州市科技计划 CPT1-A转基因小鼠的构建和代谢疾病研究
- 中国科学院院地合作项目 广东省生物医药产业发展瓶颈与对策研究
承担科研项目情况:
社会任职:
获奖及荣誉:
- L. Mao, W. Lin, T. Nie, X. Hui, X. Gao, K. Li, M. Ding, X. Tang, P. Li, Y. Wang, A. Xu, P. Liu, and D. Wu (2014). Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci 4, 60.
- K. K. Cheng, W. Zhu, B. Chen, Y. Wang, D. Wu, G. Sweeney, B. Wang, K. S. Lam, and A. Xu (2014). The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes.
- X. Li, L. Wang, X. E. Zhou, J. Ke, P. W. de Waal, X. Gu, M. H. Tan, D. Wang, D. Wu, H. E. Xu, and K. Melcher (2014). Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res.
- Song Yang, Ye Kuang, Hongbo Li, Yuehong Liu, Xiaoyan Hui, Peng Li, Zhiwu Jiang, Yulai Zhou, Yu Wang, Aimin Xu, Shiwu Li, Pentao Liu, and Donghai Wu (2013). Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site. Plos One 8.
- Nie, T., Hui, X., Gao, X., Li, K., Lin, W., Xiang, X., Ding, M., Kuang, Y., Xu, A., Fei, J., et al. (2012). Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett.
- Lin, W., Huang, X., Zhang, L., Chen, D., Wang, D., Peng, Q., Xu, L., Li, J., Liu, X., Li, K., et al. (2012). BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase. PLoS One 7, e44570.
- Bai, B., Liang, Y., Xu, C., Lee, M.Y., Xu, A., Wu, D., Vanhoutte, P.M., and Wang, Y. (2012). Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation 126, 729-740.
- Gao, S., Zhu, G., Gao, X., Wu, D., Carrasco, P., Casals, N., Hegardt, F.G., Moran, T.H., and Lopaschuk, G.D. (2011). Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A 108, 9691-9696.
- Gao, X., Li, K., Hui, X., Kong, X., Sweeney, G., Wang, Y., Xu, A., Teng, M., Liu, P., and Wu, D. (2011). Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. Biochem J 435, 723-732.
- Hui, X., Li, H., Zhou, Z., Lam, K.S., Xiao, Y., Wu, D., Ding, K., Wang, Y., Vanhoutte, P.M., and Xu, A. (2010). Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem 285, 10273-10280.
- Wen, L., Liu, J., Chen, Y., and Wu, D. (2010). Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis. Biochem Biophys Res Commun 396, 419-424.
- Zhou, M., Xu, A., Lam, K.S., Tam, P.K., Che, C.M., Chan, L., Lee, I.K., Wu, D., and Wang, Y. (2010). Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. J Hepatol 53, 1108-1116.
- Gao, Y., Zhou, Y., Xu, A., and Wu, D. (2008). Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells. Biol Pharm Bull 31, 1716-1722.
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