首页 >> 中文 >> 专家人才

专家人才

  • 姓名: 吴东海
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: wu_donghai@gibh.ac.cn
  • 通讯地址 广州萝岗区科学城开源大道190号

    简历:

    • 1980 – 1984    北京师范大学生物系学士 
      1985 – 1990    美国德州西南医学中心生物化学与分子生物学博士

    • 1990 – 1992    美国德州西南医学中心生物化学系,博士后
      1992 – 1994    美国肯塔基大学生物化学系,助理研究教授
      1994 – 1998    美国肯塔基大学生物化学系,助理教授
      1998 – 2004    美国佛罗里达大学药学院药物化学系,助理教授
      2004 – 至今     中国科学院广州生物医药与健康研究院,研究员
          

    研究领域:

    • 1.脂肪细胞褐色化机理研究:包括褐色脂肪细胞和beige脂肪细胞的分化机理研究以及白色脂肪向褐色脂肪细胞和beige脂肪细胞转分化研究。 

      2.白色脂肪细胞分化的机理研究:包括生理条件下白色脂肪细胞分化分化的分子机理研究,以及其他来源的细胞向白色脂肪细胞转分化的研究。 

      3.脂肪酸代谢的分子研究:利用基因敲除、转基因小鼠等动物模型,研究长链脂肪酸的代谢情况在各个器官中的作用。 

    承担科研项目情况:

    • 2004CB720102     973计划                                             与疾病相关抗体的结构与功能研究
    • 30670457               国家自然科学基金                            肉碱棕榈酰转移酶1c的功能研究
    • 30710527              国家自然科学基金国际合作项目      肉碱棕榈酰转移酶1c对脂肪细胞因子的调控研究
    • 30810099              国家自然科学基金国际合作项目      APPL1介导脂联素心脏保护作用的功能研究
    • 2007Z2-E4021      广州市科技计划                                 CPT1-A转基因小鼠的构建和代谢疾病研究
    •                                  中国科学院院地合作项目                  广东省生物医药产业发展瓶颈与对策研究

    社会任职:

    获奖及荣誉:

    代表论著:

      1. L. Mao, W. Lin, T. Nie, X. Hui, X. Gao, K. Li, M. Ding, X. Tang, P. Li, Y. Wang, A. Xu, P. Liu, and D. Wu (2014). Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci 4, 60.
      2. K. K. Cheng, W. Zhu, B. Chen, Y. Wang, D. Wu, G. Sweeney, B. Wang, K. S. Lam, and A. Xu (2014). The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes.
      3. X. Li, L. Wang, X. E. Zhou, J. Ke, P. W. de Waal, X. Gu, M. H. Tan, D. Wang, D. Wu, H. E. Xu, and K. Melcher (2014). Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res.
      4. Song Yang, Ye Kuang, Hongbo Li, Yuehong Liu, Xiaoyan Hui, Peng Li, Zhiwu Jiang, Yulai Zhou, Yu Wang, Aimin Xu, Shiwu Li, Pentao Liu, and Donghai Wu (2013). Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site. Plos One 8.
      5. Nie, T., Hui, X., Gao, X., Li, K., Lin, W., Xiang, X., Ding, M., Kuang, Y., Xu, A., Fei, J., et al. (2012). Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett.
      6. Lin, W., Huang, X., Zhang, L., Chen, D., Wang, D., Peng, Q., Xu, L., Li, J., Liu, X., Li, K., et al. (2012). BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase. PLoS One 7, e44570.
      7. Bai, B., Liang, Y., Xu, C., Lee, M.Y., Xu, A., Wu, D., Vanhoutte, P.M., and Wang, Y. (2012). Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation 126, 729-740.
      8. Gao, S., Zhu, G., Gao, X., Wu, D., Carrasco, P., Casals, N., Hegardt, F.G., Moran, T.H., and Lopaschuk, G.D. (2011). Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A 108, 9691-9696.
      9. Gao, X., Li, K., Hui, X., Kong, X., Sweeney, G., Wang, Y., Xu, A., Teng, M., Liu, P., and Wu, D. (2011). Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. Biochem J 435, 723-732.
      10. Hui, X., Li, H., Zhou, Z., Lam, K.S., Xiao, Y., Wu, D., Ding, K., Wang, Y., Vanhoutte, P.M., and Xu, A. (2010). Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem 285, 10273-10280.
      11. Wen, L., Liu, J., Chen, Y., and Wu, D. (2010). Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis. Biochem Biophys Res Commun 396, 419-424.
      12. Zhou, M., Xu, A., Lam, K.S., Tam, P.K., Che, C.M., Chan, L., Lee, I.K., Wu, D., and Wang, Y. (2010). Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. J Hepatol 53, 1108-1116.
      13. Gao, Y., Zhou, Y., Xu, A., and Wu, D. (2008). Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells. Biol Pharm Bull 31, 1716-1722.
    •