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专家人才

  • 姓名： 刘兴国
  • 性别： 男
  • 职称： 研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: liu_xingguo@gibh.ac.cn
  • 通讯地址 广州市开源大道190号

    简历：

  • 2002年-2006年：清华大学生物科学与技术系，博士

    1998年-2002年：山东大学生命科学学院，学士

    2007年-2010年: Thomas Jefferson University, 博士后

    2010年－至今： 中国科学院广州生物医药与健康研究院 研究员

    ·8个国际杂志编委

    ·亚洲线粒体研究与医学学会常务理事

    研究领域：

  • ·干细胞命运调控中的核与线粒体等细胞器重塑

    ·人类线粒体疾病的病理与干细胞治疗

    承担科研项目情况：

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    社会任职：

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    获奖及荣誉：

  • ·国家自然科学“杰出青年“基金

    ·国家重点研发计划首席科学家

    ·国家自然科学优秀青年基金

    ·长江学者奖励计划青年学者

    ·2016年干细胞青年研究员奖

    ·广东省特支计划－科技创新“领军人才”

    ·广东省自然科学杰出青年基金获得者（首届）

    ·国际生物物理学会 "2011 Young Bioenergeticist award"

    ·中国科学院广州教育基地优秀研究生导师

    ·中国科学院广州分院优秀青年科学家

    代表论著：

  • 1.      Ying, Z., Xiang G., Zheng, L., …& Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.

    2.      Ying, Z., Chen K., Zheng L., …& Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1): 220-226.

    3.      Li, L., Chen, K., Wang, T., ……Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2020, 2(9):882-892. 

    4.      Li, S., Guo, J., Ying, Z., ... & Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739.

    5.      Wu, Y., Chen, K., Xing, G., …& Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11): eaax7525。

    6.      Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1): e99165 (F1000 recommendation)

    7.      Xiang, G., Yang, L., Long, Q., …& Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9): 1543-1555.

    8.      Zhou, Y., Long, Q., Wu, H., …& Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (Cover Story)

    9.      Chen, K., Long, Q., Wang, T., … Liu, X* & Pei, D*. (2016) Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Reports,17(11): 1641-1656. (co-corresponding author)

    10.   Yang, L., Lin, X., Tang, H.,....Liu, X*. (2020).  Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell 19(9):e13206.

    11.   Yang, L., Long, Q., Liu, J., ... & Liu, X*. (2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA. Cellular and Molecular Life Sciences, 72(13):2585-2598.

    12.   Bao, F., Shi, H., Gao, M.,…& Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death & Disease, 9(10): 966.

    13.   Li, L., Chen, K., Wu, Y., …& Liu, X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death Disease, 8(10): e3107.

    14.   Lin, Y., Xiao, M., Chen, H., Meng, Y., Zhao, N., Yang, L., Tang, H., Wang, J., Liu, X*, Zhu, Y.*, Zhuang, S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death & Disease, 10(7):528. (co-corresponding author)

    15.   Wu, Y., Chen, K., Liu, X., ... & Liu, X*. (2015). Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming. Stem Cells, 34(1): 83-92.

    16.   Yang, L., Tang, H., Lin, X....& Liu, X*. (2020) OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. Frontiers in Cell and Developmental Biology, 8: 180.

    17.   Long, Q., Zhao, D., Fan, W., ... Wang X* & Liu, X*. (2015). Modeling of Mitochondrial Donut Formation. Biophysical Journal, 109(5), 892-899. (co-corresponding author)

    18.   Bao, F., Shi, H., Long, Q., …& Liu, X*. (2016). Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration. CNS Neuroscience & Therapeutics, 22(8), 648-660. (Cover Story)

    19.   Liu, W., Long, Q., Chen, K., ... & Liu, X*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. Biochemical and Biophysical Research Communications, 431(4), 767-771.

    20.   Liu, X., Weaver, D., Shirihai, O., & Hajnóczky, G. (2009). Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics. The EMBO Journal, 28(20), 3074-3089. (F1000 recommendation)

    21.   Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress. Cell Death & Differentiation, 18(10), 1561-1572. (F1000 recommendation)

    22.   Weaver, D., Eisner, V., Liu, X., … & Hajnóczky, G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Molecular Cell, 54(5), 870-878. (co-first author)