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专家人才

  • 姓名: 蔡景蕾
  • 性别: 女
  • 职称: 副研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: cai_jinglei@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历:

  •   2003-2008 韩国延世大学牙科学院 博士 

      2009-2011 中国科学院广州生物医药与健康研究院 助理研究员 

        2012 至今 中国科学院广州生物医药与健康研究院 副研究

    研究领域:

  •   诱导多能干细胞(iPS)的分化及器官发生发育再生 

    承担科研项目情况:

  • 国家重点研发计划课题:成体、多能干细胞牙向分化及其调控机制研究

    国家自然科学基金面上项目:牙胚间充质细胞诱导成牙的关键信号及其在ips牙向分化中的应用研究

    广州市科学(技术)研究专项一般项目:牙胚间充质细胞诱导成牙的关键信号

    中国科学院青年创新促进会会员人才项目:诱导多能性干细胞(iPS)向外胚层牙源间充质细胞分化的研究

    科技部973计划课题: 基于多能性差异机制的安全高效重编程及造血细胞定向分化新技术探索

    国家自然科学基金青年项目:不同组织来源的人多能干细胞(iPS)及其衍生的神经前体细胞免疫原性比较研究

    社会任职:

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    获奖及荣誉:

  • 2006 IADR国际会议(韩国分会)科研论文优秀奖

    2007韩国高校基础科研论文铜奖

    2008韩国高校基础科研论文金奖

    2017中国科学院杰出科技成就奖(主要完成者之一)

    代表论著:

  • 1. Yang D, Chen S, Gao C, Liu X, Zhou Y, Liu P*, Cai J*. Chemically defined serum-free conditions for cartilage regeneration from human embryonic stem cells. Life Sci. 2016 Sep 12. (co-corresponding author)

    2. Zheng Y, Cai J, Hutchins AP, Jia L, Liu P, Yang D, Chen S, Ge L, Pei D, Wei S. Remission for Loss of Odontogenic Potential in a New Micromilieu In Vitro. PLoS One. 2016 Apr 6;11(4):e0152893

    3. Liu P, Cai J, Dong D, Chen Y, Liu X, Wang Y, Zhou Y. Effects of SOX2 on Proliferation, Migration and Adhesion of Human Dental Pulp Stem Cells. PLoS One. 2015 Oct 23;10(10):e0141346.

    4. Liu P, Zhang Y, Chen S, Cai J*, Pei D*. Application of iPS Cells in Dental Bioengineering and Beyond. Stem Cell Rev. 2014 Oct;10(5):663-70. (co-corresponding author).

    5. Huang K, Liu P, Li X, Chen S, Wang L, Qin L, Su Z, Huang W, Liu J, Jia B, Liu J, Cai J*, Pei D*, and Pan G*. Neural Progenitor Cells from Human Induced Pluripotent Stem Cells Generated Less Autogenous Immune Response. Sci China Life Sci. 2014 Feb;57(2):162-70. (co-corresponding author). 

    6. Liu P, Chen S, Li X, Huang K, Wang L, Huang W, Jia B, Zhong M, Qin L, Pan G*, Cai J*, and Pei D*. Low Immunogenicity of Neural progenitor cells differentiated from Induced Pluripotent Stem Cells Generated from Less Immunogenic Somatic Cells. PLOS ONE. 2013 Jul 26;8(7):e69617. doi: 10.1371/journal.pone.0069617. Print 2013. (co-corresponding author).

    7. Cai J, Zhang Y, Liu P, Chen S, Wu X, Sun Y, Li A, Huang K, Luo R, Wang L, Liu Y, Zhou T, Wei S, Pan G, and Pei D. Generation of Tooth-like Structures from Integration-free Human Urine Induced Pluripotent Stem Cells. Cell regeneration. 2013, 2:6     

      8. Su H, Wang L, Cai J, Yuan Q, Yang X, Yao X, Wong WM, Huang W, Li Z, Wan JB, Wang Y, Pei D, So KF, Qin D, Wu W. Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle. Stem Cell Res. 2013 Mar 5;11(1):529-539.  

      9. Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA, Pei D. Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem. 2010 Apr 9;285(15):11227-34. 

      10. Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 2010 Jan 8;6(1):71-9.  

      11. Cai J, Mutoh N, Shin JO, Tani-Ishii N, Ohshima H, Cho SW, Jung HS. Wnt5a plays a crucial role in determining tooth size during murine tooth development. Cell Tissue Res. 2011 Sep;345(3):367-77. (co-first author)  

      12. Cai J, Kwak S, Lee JM, Kim EJ, Lee MJ, Park GH, Cho SW, Jung HS. Function analysis of mesenchymal Bcor in tooth development by using RNA interference. Cell Tissue Res. 2010 Aug;341(2):251-8. (co-first author)   

      13. Cai J, Cho SW, Ishiyama M, Mikami M, Hosoya A, Kozawa Y, Ohshima H, Jung HS. Chick tooth induction revisited. J Exp Zool B Mol Dev Evol. 2009 Jul 15;312B(5):465-72.   

      14. Cai J, Cho SW, Kim JY, Lee MJ, Cha YG, Jung HS. Patterning the size and number of tooth and its cusps. Dev Biol. 2007 Apr 15;304(2):499-507. (co-first author)