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专家人才

  • 姓名: Alexander Strunnikov
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: alex@gibh.org
  • 通讯地址 广州市科学城开源大道190号

    简历:

  • 2009-至今:美国国家卫生研究院过敏和传染病研究所免疫病理学实验室   高级科学家

    1996-2008:美国国家卫生研究院基因调控与发育实验室  研究员

    1992-1996:  华盛顿卡内基研究所胚胎系D. Koshland博士实验室  博士后

    1989-1991:俄罗斯科学院细胞研究所V. Larionov博士有丝分裂基因学实验室研究生

    1989:BioTechnika Ltd. 和 匈牙利生物研究中心  访问学者

    1987-1988:俄罗斯科学院细胞研究所染色体稳定与细胞工程实验室  研究实习员

    1985-1986:圣彼得堡流感研究所生物技术研究中心 基因工程系  实习和技术员

                                                                  

    2009-至今:攻读马里兰州大学生物技术和生物信息学硕士 (非全日制,2012年毕业)

    2010-2011:美国癌症研究所癌症研究中心“临床肿瘤学转化研究”继续教育课程(两个学期)

    2008-2009:美国卫生研究所非学位课程:逆转录酶病毒,动物实验操作程序,芯片技术,高通量筛选数据分析,Unix原理,高级SAS, 平行计算及其他。

    1995: Cold Spring Harbor 实验室课程:蛋白纯化与特征

    1987-1991:俄罗斯科学院细胞研究所博士学位

               导师:Dr. V. Larionov.

               论文题目:控制染色体在有丝分裂中分布的相关基因研究

    1979-1984: 圣彼得堡大学生物与遗传学学士学位(优秀)

    主修:生物学和遗传学, 兼修:生物教学

    研究领域:

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    承担科研项目情况:

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    社会任职:

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    获奖及荣誉:

  • 1999:提名为美国卫生研究院院长发言人之一

    2001:霍德休斯医学研究所导师资格

    2006:为美国政府服务十年荣誉证书

    职业协会会员资格:                            

    美国遗传协会

    美国生物细胞协会

    美国科学促进会

    参加的项目评审小组:                                             

    2005: 美国国家卫生研究院细胞核动态和运输特别研究小组

    美国国家科学基金会

    瑞士国家科学基金会

    奥地利Fonds zur Forderung der Wisscenschaftlishen Forsung,

     

    意大利癌症研究协会

    英国国际癌症研究协会

    英国威康信托基金会

    新加坡科学技术研究会

    新加坡生物医药研究理事会

    新西兰皇家马斯登基金会

    参加的演讲与学术报告                                                

    应邀在美国国内及国际会议和学术报告会上多次发表演讲:

    1994年 美国旧金山细胞生物学学会年度会议

    1995年 新墨西哥州陶斯细胞周期国际会议

    1997年 新墨西哥州圣达菲细胞核组织和功能会议

    1999年 美国国家卫生研究院学术报告演讲人

    2000年 费城美国人类遗传学会第50届会议

    2000年 美国实验生物学联合会举办的关于染色体组织和复制会议

    2002年 马尔堡大学学术报告会

    2002年 英国医学研究理事会学术报告会

    2002年 法国巴斯德研究院学术报告会

    2005年 日本冈崎机制扩大国际会议

    2005年 荷兰奈梅亨分子科学中心学术报告会

    2005年 美国吉斯通DNA复制会议

    2007年 日本静冈市细胞周期国际会议

    2007年 日本东京科技学院学术报告会

    2008年 西班牙巴塞罗那癌症预测和个体化医学中心国际研讨会

    2009年 日本冲绳理工学院学术报告会

    2010年 西班牙发展生物学安达卢西亚中心学术报告会

     

    代表论著:

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    * E. Pugacheva, T. Suzuki, S. Pack, N. Kosaka-Suzuki, J. Yoon, A. Vostrov, E. Barsov, A.Strunnikov, H. Morse III, D. Loukinov, V. Lobanenkov. (2010) The structural complexity of the human BORIS gene in gametogenesis and cancer. PLoS ONE 5:e13872

    * A. Samoshkin, A. Arnaoutov, L.E.T. Jansen, I. Ouispenski, L. Dye, T. Karpova, J. McNally, M.Dasso, Don W. Cleveland and A. Strunnikov. (2009) Human condensin function is essential for centromeric chromatin assembly and sister kinetochore orientation. PLoS ONE 4:e6831

    * S. Dulev, C. de Renty, R. Mehta, I. Minkov, E. Schwob and A. Strunnikov. (2009) Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants. PNAS 106: 14466-14471

    * Y. Takahashi, S. Dulev, X. Liu, N. Hiller, X. Zhao and A. Strunnikov (2008) Cooperation of sumoylated chromosomal proteins in rDNA maintenance. PLoS Genetics 4:e1000215

    * S. Dulev, L. Aragon, and A Strunnikov (2008) Unreplicated DNA in mitosis precludes condensin binding and chromosome condensation in S. cerevisae. Frontiers in Biosciences 13:5838-5846

    * Y. Takahashi and A. Strunnikov (2008) In vivo modeling of polysumoylation uncovers targeting of Topoisomerase II to the nucleolus via optimal level of SUMO modification. Chromosoma 117:189-198

    * B.D. Wang and A. Strunnikov (2008) Transcriptional homogenization of rDNA repeats in the episome-based nucleolus induces genome-wide changes in the chromosomal distribution of condensin. Plasmid 59:45-53

    * V. Yong-Gonzalez, B.D. Wang, P. Butylin, I. Ouspenski and A. Strunnikov (2007) Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids. Genes to Cells 12:1075-1090

    * B. D. Wang, P. Butylin and A. Strunnikov (2006) Condensin function in mitotic nucleolar segregation is regulated by rDNA transcription. Cell Cycle 5:2260-2267

    * Y. Takahashi, V. Yong-Gonzalez, Y. Kikuchi and A. Strunnikov (2006) The SIZ1/SIZ2 control of chromosome transmission fidelity is mediated by their role in sumoylation of topoisomerase II. Genetics 172:783-794

    * B. Quimby, V. Yong-Gonzalez, T. Anan, A. Strunnikov and M. Dasso (2006) The

    promyelocytic leukemia protein (PML) stimulates Sumo conjugation in yeast. Oncogene 25:2999-3005

    * B.D. Wang, D. Eyre, M. Basrai, M. Lichten and A. Strunnikov (2005) Condensin binding at distinct and specific chromosomal sites in the Saccharomyces cerevisiae genome. Molecular and Cellular Biology 25: 7216-7225

    * B. D. Wang, V. Yong-Gonzalez and A. Strunnikov. (2004) Cdc14p/FEAR pathway controls segregation of nucleolus in S. cerevisiae by facilitating condensin targeting to rDNA chromatin in anaphase. Cell Cycle 3:960-967

    * A. Kagansky, L. Freeman, D. Lukyanov, and A. Strunnikov. (2004) Histone-tail independent chromatin-binding activity of recombinant cohesin holocomplex. Journal of Biological Chemistry 279:3382-3388

    * J. Mascarenhas, J. Soppa , A. Strunnikov and P. L. Graumann (2002) Cell cycle dependent localization of two novel prokaryotic chromosome segregation and condensation proteins in Bacillus subtilis that interact with SMC protein. EMBO Journal. 21:3108-3128

    * A. Strunnikov, L. Aravind and E. V. Koonin (2001) Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics.158: 95- 107

    * L. Aragon-Alcaide and A. Strunnikov (2000) Functional dissection of in-vivo interchromosome association in S. cerevisiae. Nature Cell Biology 2: 812-818

    * L. Freeman, L.Aragon-Alcaide and A. Strunnikov (2000) The condensin complex governs chromosome condensation and mitotic transmission of rDNA. Journal of Cell Biology 149: 811-824

    * N. Darwiche, L. A. Freeman , and A. Strunnikov (1999) Characterization of the components of the putative mammalian sister chromatid cohesion complex. Gene. 233:39-47

    * P. L. Graumann, R. Losick, A. V. Strunnikov (1998) Subcellular localization of Bacillus subtilis SMC, a protein involved in chromosome condensation and segregation. Journal of Bacteriology 180:5749-5755

    * V. Guacci, D. Koshland, A.V. Strunnikov (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S.cerevisiae. Cell 91:47-57

    A. Strunnikov, E. Hogan and D. Koshland (1995) SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation defines a subgroup within the SMCfamily. Genes and Development 9: 87-599

     

    A. Strunnikov, J. Kingsbury and D. Koshland (1995) CEP3 encodes a centromere protein of Saccharomyces cerevisiae. Journal of Cell Biology 128:749-760

     

    A. Strunnikov, V. Larionov and D. Koshland (1993) SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family. Journal of Cell Biology 123:1635-1648

     

    V. Guacci, A. Yamamoto, A. Strunnikov, J. Kingsbury, E. Hogan, P. Meluh and D. Koshland (1993) Structure and function of chromosomes in mitosis of budding yeast. In: Cold Spring Harbor Symposia on Quantitative Biology /DNA and Chromosomes. 58:677-685, Cold Spring Harbor, New York

     

    V. Larionov, N. Kouprina N., A. Strunnikov and A. Vlasov (1989) A direct selection procedure for isolating yeast mutants with an impaired segregation of artificial minichromosomes. Current Genetics 15:17-26

     

    V. Larionov, N. Kouprina, A. Strunnikov, A. Vlasov and V. Pirozhkov (1989) Direct selection procedure for isolation of yeast mutants with impaired segregation of chromosomes. Progress in Clinical and Biological Research, Vol. 138: Mechanisms of chromosome distribution and aneuploidy, 303-316; Alan R. Liss, Inc., New York

    评论和图书章节                                                      

    * A. Strunnikov (2010) One-hit wonders of genomic instability. Cell Division 5: 15

    * Y. Takahashi, Iwase M, A. Strunnikov, Y. Kikuchi (2008) Cytoplasmic sumoylation by PIAStype Siz1-SUMO ligase. Cell Cycle. 7:1738-1744

    * A. Strunnikov (2006) SMC complexes in bacterial chromosome condensation and segregation. Plasmid 55:135-144

    * A. Strunnikov. (2005) A case of selfish nucleolar segregation. Cell Cycle 4: 113-117

    * A. Strunnikov. (2003) Condensin and biological role of chromosome condensation. Progress in Cell Cycle Research 5: 361-368

    * P. Meluh and A. V. Strunnikov (2002) Beyond the ABC of CKC and SCC. Do centromeres orchestrate sister chromatid cohesion or vice versa? European Journal of Biochemistry. 269:2300–2314

    * A. V. Strunnikov, R. Jessberger (1999) SMC Proteins: Conserved molecular properties for multiple biological functions. European Journal of Biochemistry. 263:6-13

    * A. V. Strunnikov (1998) SMC proteins and chromosome structure. Trends in Cell Biology. 8:454-459

    * D. Koshland and, A. Strunnikov (1996) Mitotic chromosome condensation. Annual Reviews of Cell and Developmental Biology 12:305-333