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专家人才

  • 姓名: 杜鹃
  • 性别: 女
  • 职称: 副研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: du_juan@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历:

  • 教育背景 

    01/2004- 01/2008 Ph.D. National University of Singapore, Singapore 

    09/1999- 07/2003 B.Sc. Huazhong Agricultural University, Wuhan, China 

    工作经历 

    2012.08-Present Associate Investigator, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science 

    05/2009-07/2012 Research Associate (Postdoc fellow), University of Wisconsin Madison 

    01/2008-02/2009 Research Assistant, National University of Singapore 

    研究领域:

  • Hematopoietic stem cells biology 

    Single-cell transcriptome of hematopoietic stem and progenitor cells 

    承担科研项目情况:

  • 国家重点基础研发计划:外在环境调控多能干细胞向造血干细胞分化的作用和机理研究

    国自然青年科学基金:基于GATA2敲除及GATA2-GFP标记的hES细胞系研究内皮-造血转变的调控机制

    广州市科学研究专项一般项目:MSC治疗CMML的可行性及机制研究

    社会任职:

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    获奖及荣誉:

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    代表论著:

  • u  Wang T, Xia C, Dong Y, Chen X, Wang J#, Du J#. Trim27 confers myeloid hematopoiesis competitiveness by up-regulating myeloid master genes. J Leukoc Biol. 2018 Jun 13. doi: 10.1002/JLB.1A1217-480R. [Epub ahead of print] (#Co-correspondence).

    u  Li X, Xia C, Wang T, Liu L, Zhao Q, Yang D, Hu F, Zhang M, Huang K, Geng Y, Zheng Y, Guan Y, Wu H, Chen X, Pan G, Chen J, Du J#, Wang J#. Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cellsStem Cell Res. 2017 Mar 21; 21:32-39. doi: 10.1016/j.scr.2017.03.014 (#Co-correspondence).

    u  Huang K*, Gao J*, Du J*, Ma N, Zhu Y, Wu P, Zhang T, Wang W, Li Y, Chen Q, Hutchins A, Yang Z, Zheng Y, Zhang J, Shan Y, Li X, Liao B, Liu J, Wang J, Liu B, Pan G. Generation and analysis of GATA2w/eGFP in human ESCs reveals ITGB3(CD61) as a novel marker for defining true hemogenic endothelial cells during hematopoiesis. Stem Cell Reports. 2016 Nov 8;7(5):854-868. doi: 10.1016/j.stemcr.2016.09.008. (*Equal contribution)

    u  Huang K, Du J, Ma N, Liu J, Wu P, Dong X, Meng M, Wang W, Chen X, Shi X, Chen Q, Yang Z, Chen S, Zhang J, Li Y, Li W, Zheng Y, Cai J, Li P, Sun X, Wang J, Pei D, Pan G. GATA2(-/-) human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment. Cell Regen (Lond). 2015 Aug 5;4(1): 4. doi:10.1186/s13619-015-0018-7. eCollection 2015.

    u  Kong G*, Du J*, Liu Y, Meline B, Chang Y, Ranheim EA, Wang J, Zhang J. Notch1 mutations target Kras G12D CD8+ cells and contribute to their leukemogenic transformation. J Biol Chem. 2013 Jun 21; 288(25): 18219-27. (*Equal contribution)

    u  Du J, Liu Y, Meline B, Kong G, Tan LX, Lo JC, Wang J, Ranheim EA, Zhang L, Ryu MJ, Zhang JF, Zhang J. Loss of CD44 attenuates aberrant GM-CSF signaling in Kras G12D hematopoietic progenitor/precursor cells and prolongs the survival of diseased animals. Leukemia. 2013 Mar;27(3):754-7. doi: 10.1038/leu.2012.251. Epub 2012 Aug 31.

    uDu J*, Wang J*, Kong G, Zhang JF, Liu Y, Zhang J. Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells. Stem Cells. 2012 Jul; 30(7): 1447-54. (*Equal contribution)