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专家人才

  • 姓名: 张艳梅
  • 性别: 女
  • 职称: 高级工程师
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: zhang_yanmei@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历:

  •   学习工作经历 

      2011.3至今        研究员,中国科学院广州生物医药与健康研究院 

      2007.12-2010.11    博士后,美国加州大学圣地亚哥分校癌症研究中心 

      2006.7-2007.6      博士后,英国圣特安德鲁斯大学化学院 

      2001.11-2005.2      博士,德国慕尼黑工业大学化学院 

      1998.7-2001.6       助理研究员,中国科学院上海药物化学研究所 

      1995.9-1998.6       硕士,中国科学院上海有机化学研究所 

      1991.9-1995.7       学士,中国山东大学化学院 

      1995年毕业于山东大学化学系。同年,进入中国科学院有机化学研究所攻读硕士学位,进行有机含氟合成片段和含氟有机活性小分子的合成研究。毕业后,加入国家新药筛选中心,负责化合物库的建立,主要是运用组合化学和天然产物提纯的手段获取有机小分子。2001年,进入德国慕尼黑工业大学化学系进行博士学位的学习,主要从事有机催化和方法学的研究, 取得一系列的突破性进展。于2004年底获得博士学位后,继续在英美著名学府工作学习。回国之前,师从Dennis Carson教授,在UCSD癌症中心工作,设计合成AdSS抑制剂和TLR7激动剂。在工作中,既从事有机小分子的设计和合成工作,同时也进行药物制剂的研究,特别对有机小分子的脂质体的制备和应用有深入的研究。20113月,加入GIBH,目前从事抗癌抗炎药物设计合成以及药物制剂实验室的建立和药物分析实验室的规范化工作。 

        

    研究领域:

    承担科研项目情况:

    社会任职:

    获奖及荣誉:

    代表论著:

  •   发表论文情况 

      1. Zhang Yanmei*Dan Wei-Xing; Liu Jianqi; Tortorella D. Micky; Tu Zhengchao; Talley J. John*; Palladium-Catalyzed Synthesis of Trimethylsilyl Substituted Benzopyran Derivatives, The Open Organic Chemistry Journal, 2013, 7, 15-20 

      2. Chan Michael; Hayashi Tomoko; Mathewson Richard D.; Yao Shiyin; Gray Christine; Tawatao Romel I.; Kalenian Kevin; Zhang Yanmei; Hayashi Yuki; Lao Fitzgerald S.; Cottam Howard and Carson Dennis. Synthesis and Characterization of PEGylated Toll Like Receptor 7 Ligands, Bioconjugate Chemistry, 2011, 22, 445-454. 

      3. Zhang Yanmei; Saldanha Adrian; Elliott Greg; Tsygelny Igor; Carson Dennis and Wrasidlo Wolf. Synthesis of 5-(6-hydroxy- 7H-purine -8-ylthio)-2- (N-hydroxyformamido) pentanoic acid, Beilstein J. Org. Chem. 2010, 6, 742-747. 

      4. Hijazi Ahmed; Yeong Hui Yee; Zhang Yanmei; Herdtweck Eberhardt; Nuyken Oskar; Kühn Fritz E. Isobutene Polymerization Using [CuII(NCME)6]2+with Non Coordinating Anions as Catylysts, Macromol. Rapid Com. 2007, 28, 670-675. 

      5. Nuyken Oskar; Vierle Mario; Kühn Fritz E.; Zhang Yanmei. Solvent-Ligated Transition Metal Complexes as Initiators for the Polymerization of Isobutene, Macromolecular Symposia 2006, 236, 69-77. 

      6. Zhang Yanmei; Sun Wei; Freund C.; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Cationic copper(I) and silver(I) nitrile complexes with fluorinated weakly coordinating anions: metal-nitrile bond strength and its influence on the catalytic performance, Inorg. Chim. Acta. 2006, 359, 4723-4729. 

      7. Zhang Yanmei; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Organonitrile Ligated Silver Complexes with Perfluorinated Weakly Coordinating Anions as Active Catalysts for Coupling Reactions, New. J. Chem. 2005, 29, 366-370. 

      8. Zhang Yanmei; Sun Wei; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Synthesis, characterization, and catalytic application of Copper(I) nitrile cations with perflurinated weakly coordinating anions, Catalysis Letters 2005, 101, 35-41. 

      9. Vierle Mario; Zhang Yanmei; Köhler Klaus; Haessner Carmen; Santos Ana M.; Herdtweck Eberhardt; Nuyken Oskar and Kühn Fritz E. Solvent Ligated Manganese (II) Complexes for the Homopolymerization of Isobutene and the Copolymerization of Isobutene and Isoprene, Chem. Eur. J. 2004, 10, 6323-6332. 

      10. Gago Sandra; Zhang Yanmei; Santos Ana M.; Köhler Klaus; Kühn Fritz E.; Fernandes Jose A.; Pillinger Martyn; Valente Anabela A.; Santos Teresa M.; Ribeiro-Claro Paulo; Goncalves Isabel S. Synthesis and characterization of a Manganese(II) acetonitrile complex supported on functionalized MCM-41, Microporous and Mesoporous Materials, 2004, 76, 131-136. 

      11. Kühn Fritz E.; Zuo Jing-Lin; Fabrizi de Biani Fabrizia; Santos Ana M.; Zhang Yanmei; Zhao Jin; Sandulache Angela and Herdtweck Eberhardt. 4-Ethynylpyridine as bridging moiety in mixed Ru/Re complexes, New J. Chem. 2004, 28, 43-51. 

      12. Vierle Mario; Zhang Yanmei; Herdtweck Eberhardt; Bohnenpoll Martin; Nuyken Oskar; Kuhn Fritz E. Highly reactive polyisobutene prepared with manganese(II) complexes as initiators, Angewandte Chemie, International Edition 2003, 42, 1307-1310. 

      13. Qing Feng-Ling; Ying Jiewen;  Zhang Yanmei. A stereoselective synthesis of ethyl 9-cis-7,8-didehydro-19-trifluoromethylretinoate, Journal of Fluorine Chemistry 2000, 101, 31-33. 

      14. Qing Feng-Ling; Zhang Yanmei. Ethyl 3-Iodo-4,4,4-trifluoro-2(Z) -butenoate: regio- and stereospecific preparation and palladium-catalyzed reaction with terminal alkynes, Tetrahedron Letters 1997, 38, 6729-6732. 

        

      专利 

      1Walter, Hans-Michael; Herrlich-Loos, Mirjam; Kuehn, Fritz Elmar; Zhang, Yanmei; Voit, Brigitte; Narayanan, Radha Krishnan. Solvent-stable metal complexes having weakly coordinating counteranions as polymerization catalysts. PCT Int. Appl. (2007), WO 2007020247. 

      2. Rath, Hans Peter; Walter, Hans-Michael; Nuyken, Oskar; Kuehn, Fritz Elmar; Zhang Yanmei; Yeong, Hui Yee; Voit, Brigitte; Narayanan, Radha Krishnan. Method for producing copolymers made from isobutene and at least one vinylaromatic component. PCT Int. Appl. (2007), WO 2007020248. 

      3. Rath, Hans Peter; Walter, Hans-Michael; Nuyken, Oskar; Kuehn, Fritz Elmar; Zhang Yanmei; Yeong, Hui Yee. Polymerization of ethylenically unsaturated monomers using solvent-stable transition metal complex as catalyst. PCT Int. Appl. (2007) WO 2007020246. 

      4. Rath, Hans Peter; Walter, Hans-Michael; Nuyken, Oskar; Kuehn, Fritz Elmar; Zhang Yanmei; Yeong, Hui Yee. Method for producing copolymers made from isobutene and at least one vinylaromatic component. US Patent Application No:2009/0105,432. 

      5. Walter, Hans-Michael; Herrlich-Loos, Mirjam; Kuehn, Fritz Elmar; Zhang Yanmei; Voit, Brigitte; Narayanan, Radha Krishnan. Solvent-stable metal complexes having slightly coordinating counter anions as polymerization catalysts. US Patent Application No: 2008/0221,285. 

      6. Zhang Yanmei; Talley John J.; Obukowiz Mark G.; Tu Zhengchao; Tortorella Micky; Wang Yican; Liu Jianqi; Chen Yan; Liu Xiaorong; Lu Xin. Substituted benzopyran derivatives for the treatment of inflammation, 201210202059X, PCT App.No.: PCT/CN2012/079968. 

      7. Zhang Yanmei; Talley John J.; Dan Wei-Xing; Tu Zhengchao; Lu Xin; Chen Yan. Trimethylsilyl Substituted benzopyran derivatives for the treatment of inflammation, 2012105283493. 

      8. Zhang Yanmei; Talley John J.; Wang Yican; Liu Jianqi. Synthesis of chiral benzopyran derivatives, 2012105253267. 

      9. Zhang Yanmei; Ding Ke; Liao Jin-Xi; Wang Yican; Liu Jianqi. Coupling derivatives of NSAIDs drug and EGFR inhibitors for the treatment of inflammation, 2012104685916. 

      10. 张艳梅,丁克,程辉敏,廖进喜,苯甲酰胺类化合物或其药学上可接受的盐及其应用,申请号:201310422397.9