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专家人才

  • 姓名: 郭琳
  • 性别: 女
  • 职称: 副研究员
  • 学历: 博士
  • 电话: 020-32015291
  • 传真: 
  • 电子邮件: guo_lin09@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    研究领域:

  • 1.    多能性建立与维持的分子机制

    2.    利用单细胞测序技术研究细胞命运决定

    承担科研项目情况:

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    社会任职:

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    获奖及荣誉:

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    代表论著:

  • 1.Chen, J.*, Guo, L.*, Zhang, L.*, Wu, H., Yang, J., Liu, H., Wang, X., Hu, X., Gu, T., Zhou, Z., Liu, J., Liu, J., Wu, H., Mao, S.Q., Mo, K., Li, Y., Lai, K., Qi, J., Yao, H., Pan, G., Xu, G.L., and Pei, D. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet, 2013. 45(12): 1504-1509. (*共同第一作者)

    2.Chen, Y.*, Guo, L.*, Chen, J.*, Zhao, X., Zhou, W., Zhang, C., Wang, J., Jin, L., Pei, D., and Zhang, F. Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity. BMC Genomics, 2014. 1579.

    3. 郭琳,陈捷凯,裴端卿,维生素C与表观遗传调控,科学通报,2014, 59 (28) :2833-2839

    4.Li, D.*, Liu, J.*, Yang, X.*, Zhou, C., Guo, J., Wu, C., Qin, Y., Guo, L., He, J., Yu, S., Liu, H., Wang, X., Wu, F., Kuang, J., Hutchins, A.P., Chen, J., and Pei, D. Chromatin Accessibility Dynamics during iPSC Reprogramming. Cell Stem Cell, 2017. 21(6): 819-833 e816.

    5.Chen, J.*, Liu, H.*, Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Chen, J., Wu, Y., Guo, L., Zhu, J., Zhao, X., Peng, T., Zhang, Y., Chen, S., Li, X., Li, D., Wang, T., and Pei, D. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2013. 45(1): 34-42.

    6.Chen, J.*, Liu, J.*, Chen, Y., Yang, J., Chen, J., Liu, H., Zhao, X., Mo, K., Song, H., Guo, L., Chu, S., Wang, D., Ding, K., and Pei, D. Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Res, 2011. 21(6): 884-894.