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专家人才

  • 姓名: 张小飞
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: zhang_xiaofei@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历:

  • 2001-2005 安徽农业大学 植物保护  学士 

    2005-2008 中国科学技术大学生物化学与分子生物学(广州生物医药与健康研究院) 硕士  

    2009-2013 荷兰莱顿大学 分子与细胞生物学 博士 

    2013-2014 荷兰莱顿大学 分子与细胞生物学 博士后 

    2014-2017 荷兰内梅亨大学 分子与细胞生物学 博士后 

    2017-至今  中科院广州生物医药与健康研究院 研究员 

    研究领域:

  • 利用蛋白质谱研究信号通路,泛素化在细胞命运转换中的作用

    承担科研项目情况:

    社会任职:

    获奖及荣誉:

    代表论著:

  • 1. Xiaofei Zhang*#, Arne H. Smits, Gabrielle B.A. van Tilburg, Pascal W.T.C. Jansen, Matthew M. Makowski, Huib Ovaa, Michiel Vermeulen. An Interaction Landscape of Ubiquitin Signaling. Molecular Cell 65, 941–955 (2017). 

    2. Juan Zhang, Xiaofei Zhang, Feng Xie, Zhengkui Zhang, Hans van Dam, Long Zhang, Fangfang Zhou. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein & cell 2014Apr; 5 (7), 503-517.  

    3. Xiaofei Zhang, Juan Zhang, Andreas Bauer, Long Zhang, Douglas W Selinger, Chris X. Lu, and Peter ten Dijke. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO. J.,2013 Apr 3;32(7):996-1007.  

    4. Xiaofei Zhang, Juan Zhang, Hans van Dam, Peter ten Dijke. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Research., 2013 Mar; 23(3):366-77.  

    5. Juan Zhang, Xiaofei Zhang, Long Zhang, Fangfang Zhou, Maarten van Dinther, Peter ten Dijke. LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation. J Bone Miner Res., 2012 Oct;27(10):2065-74.  

    6. Fangfang Zhou, Xiaofei Zhang, Hans van Dam, Peter ten Dijke, Huizhe Huang, Long Zhang. Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem. 2012 Mar 30;287(14):11002-10.  

    7. Jianyong Xu, Huapeng Li, Bo Wang, Yan Xu, Jiayin Yang, Xiaofei Zhang, Sarah K. Harten, Deepa Shukla, Patrick H. Maxwell, Duanqing Pei, and Miguel A. Esteban. VHL Inactivation Induces HEF1 and Aurora Kinase A. J Am Soc Nephrol., 2010 Dec;21(12):2041-6.  

    8. Juan Zhang, Xiaofei Zhang, Yunqian Guo, Liangliang Xu and Duanqing Pei. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with wiskott-aldrich syndrome protein. J. Biol. Chem., 2009; 284(32):21659-69.  

    9. Juan Zhang, Xiaofei Zhang, and Duanqing Pei. Mutations of Nuclear Localization Signals in mNANOG generate Dominant Negative Mutants. Chinese Science Bulletin., 2009; 54 (8): 1361-1368.  

    10.Xiaofei Zhang, Juan Zhang, Tao Wang, Miguel A. Esteban, and Duanqing Pei. Esrrb activates oct4 transcription and sustains self renewal and pluripotency in embryonic stem cells. J. Biol. Chem., 2008; 283(51):35825-33. 

    代表共第一作者;代表共通讯作者 

    专利 

    裴端卿;张娟;张小飞 分选蛋白33在肿瘤治疗中的应用 200910039731.6 

    奖励 

    裴端卿,秦大江,潘光锦,张小飞   诱导多能干细胞机理与技术研究  广东省科学技术一等奖 

    裴端卿、潘光锦、秦宝明、秦大江、张小飞  干细胞多能性与重编程机理研究  国家自然科学二等奖