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专家人才

  • 姓名: 陈可实
  • 性别: 男
  • 职称: 副研究员
  • 学历: 博士
  • 电话: 020-32015340
  • 传真: 
  • 电子邮件: chen_keshi@gibh.ac.cn
  • 通讯地址 广州市开源大道190号

    简历:

  •   2004/9 - 2008/7,中国科学技术大学,生物技术,学士;
      2008/9 - 2013/6,中国科学院大学,生物化学和分子生物学,博士;

      2013/7 – 2016/12,中国科学院广州生物医药与健康研究院,助理研究员;

      2017/1 – 至今,中国科学院广州生物医药与健康研究院,副研究员。

    研究领域:

  •   
      主要从事“胚胎干细胞与重编程”领域的研究

    承担科研项目情况:

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    社会任职:

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    获奖及荣誉:

  •   中国科学院青年创新促进会会员(2017

    代表论著:

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      1.Keshi Chen#, Qi Long#, Tao Wang, Danyun Zhao, Yanshuang Zhou, Juntao Qi, Yi Wu, Shengbiao Li, Chunlan Chen, Xiaoming Zeng, Jianguo Yang, Zisong Zhou, Weiwen Qin, Xiyin Liu, Yuxing Li, Yingying Li, Xiaofen Huang, Dajiang Qin, Jiekai Chen, GuangjinPan, Hans R Sch?ler, Guoliang Xu, Xingguo Liu*, Duanqing Pei*. Gadd45a is a heterochramatin relaxer that enhances iPS cell generation, EMBO Reports, 17, 1641-1656, 2016 (co-First authors)(IF=8.568

     

      2. Linpeng Li#, Keshi Chen#, Yi Wu, Qi Long, Danyun Zhao, Bochao Ma, Duanqing Pei, Xingguo Liu*. Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Cell Death & Disease, 8, e3107, 2017 (co-First authors) (IF=5.965)

     

      3.Yi Wu#, Keshi Chen#, Xiyin Liu, Lili Huang, Danyun Zhao, Linpeng Li, Mi Gao, Duanqing Pei, Chenguang Wang, Xingguo Liu*. Srebp-1 interacts with c-Myc to enhance somatic cell reprogramming, Stem Cells, 34, 83-92, 2016 (co-First authors)(IF=5.599

     

      4. Danyun Zhao, Yi Wu, Keshi Chen*. Tbx3 isofroms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, Biochem Biophys Res Commun, 444, 411-414, 2014Corresponding author)(IF=2.466

     

      5.Tao Wang, Keshi Chen, Xiaoming Zeng, Jianguo Yang, Yun Wu, Xi Shi, Baoming Qin, Lingwen Zeng, Miguel Angel Esteban, Guangjin Pan, and Duanqing Pei*. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner, Cell Stem Cell, 9, 575-587, 2011 IF=23.394

     

      6.Zhongfu Ying, Keshi Chen, Lingjun Zheng, Yi Wu, Linpeng Li, Rui Wang, Qi Long, Liang Yang, Jingyi Guo, Deyang Yao, Yong Li, Feixiang Bao, Ge Xiang, Jinglei Liu, Andrew Paul Hutchins, Duanqing Pei and Xingguo Liu*. Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming, Cell Metabolism, 23, 220-226, 2016 IF=18.164

     

      7.Miguel Angel Esteban, Tao Wang, Baoming Qin, Jiayin Yang, Dajiang Qin, Jinglei Cai, Wen Li, Zhihui Weng, Jiekai Chen, Su Ni, Keshi Chen, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71-79, 2010IF=23.394

     

      8.Wenbo Liu, Qi Long, Keshi Chen, Shengbiao Li, Ge Xiang, Shen Chen, Xiyin Liu, Yuxing Li, Liang Yang, Delu Dong, Cheng Jiang, Zhenhua Feng, Dajiang Qin, Xingguo Liu*. Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation, Biochem Biophys Res Commun, 431, 767-771, 2013IF=2.466

     

      9.Shengbiao Li, Jingyi Guo, Zhongfu Ying, Shen Chen, Liang Yang, Keshi Chen, Qi Long, Dajiang Qin, Duanqing Pei, Xingguo Liu*. Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mPTP opening dependent apoptotic sensitivity in an iPSC model, Hepatology, 61, 1730-1739, 2015IF=13.246

     

      10. Ge Xiang, Liang Yang, Qi Long, Keshi Chen, Haite Tang, Yi Wu, Zihuang Liu, Yanshuang Zhou, Juntao Qi, Lingjun Zheng, Wenbo Liu, Zhongfu Ying, Weimin Fan, Hongyan Shi, Hongmei Li, Xiaobing Lin, Mi Gao, Jinglei Liu, Feixiang Bao, Linpeng Li, Lifan Duan, Min Li, Xingguo Liu*. BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during SKO-induced Somatic Cell Reprogramming, Autophagy, 13, 2017 (IF=8.593)

     

      授权专利:

      1、刘兴国;裴端卿;陈可实;龙琪;王涛,改变细胞命运的方法,ZL201310265256.0。