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专家人才

  • 姓名: 陈小平
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: chen_xiaoping@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历:

  •   1977-1980广东医科大学临床医学专业。

      1985-1988中山医科大学传染病学专业硕士研究生,获医学硕士学位。

      1995-1998中山医科大学病原生物学专业博士研究生,获医学理学博士学位。期间于1997在美国加州大学(UCLA)医学院作访问学者。

      1980-1985广东医科大学附属医院感染科医师、助教。

      1988-19951998-2004广州市疾病预防控制中心先后任助理研究员、副研究员、研究员,微生物科主任、艾滋病研究室主任。

      2004-现在,中国科学院广州生物医药与健康研究院研究员,博士生导师,博士后合作导师。曾任院长助理、感染与免疫研究中心主任、呼吸疾病国家重点实验室副主任。

     

    研究领域:

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      长期从事疟原虫生物学和免疫学研究,包括疟原虫与肿瘤的相互作用、疟原虫与艾滋病毒的相互作用研究。目前主要从事疟原虫免疫疗法治疗癌症的基础与临床研究及新型抗疟药的开发。陈小平团队发现疟原虫感染可以拮抗肿瘤免疫抑制微环境,启动抗肿瘤天然和适应性免疫应答,抑制肿瘤血管生成,抑制肿瘤的生长和转移,显著延长肺癌、肝癌、结肠癌和乳腺癌等实体肿瘤荷瘤小鼠的寿命。与钟南山院士团队等合作,在多家医院开展疟原虫免疫疗法治疗晚期肺癌和其它晚期实体肿瘤的临床试验。与美国圣-路易斯大学合作开发以疟原虫天冬氨酸蛋白酶为靶点的新型抗疟药。目前主要招收博士后研究人员。主持和参与国家863973科技计划,国家传染病重大专项、科技部重点攻关项目,美国NIH与国家自然科学基金联合资助项目,多项国自然,中科院科技攻关等十多项科技计划的实施。发表科研论文90余篇,申请和获授权发明专利20项。

     

    承担科研项目情况:

    社会任职:

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      广东省免疫学会副理事长。
     

    获奖及荣誉:

    代表论著:

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    1. Yu S, YaoY, Xiao H, Li J, Liu Q, Yang Y , Adah D, Lu J, Zhao S, Qin L, Chen X. Simultaneously knockout of CXCR4 and CCR5 genes in CD4+ T cells via CRISPR/Cas9 confers resistance to both X4- and R5-tropic HIV-1 infection. Human Gene Therapy. 2017.

    2. Qin L, Chen C, Chen L, Xue R, Ou-Yang M, Zhou C, Zhao S, He Z, Xia Y, He J, Liu P, Zhong N, Chen X. Worldwide malaria incidence and cancer mortality are inversely associated. Infect Agent Cancer. 2017, 12:14.

    3. Liu Q, Yang Y, Tan X, Tao Z, Adah D, Yu S, Lu J, Zhao S, Qin L, Qin L, Chen X. Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector. Oncotarget. 2017, 8(15):24785-24796.

    4.Yang Y, Liu Q, Lu J, Adah D, Yu S, Zhao S, Yao Y, Qin L, Qin L-M, Chen X.    Exosomes from Plasmodium-infected hosts inhibit tumor angiogenesis in a murine Lewis lung cancer model. Oncogenesis, 2017, 6 (6):e351.

    5.Lu J, Tong Y, Pan J, Yang Y, Liu Q, Tan X, Zhao S, Qin L, Chen X. A redesigned CRISPR/Cas9 system for marker-free genome editing in Plasmodium falciparum. Parasit Vectors. 2016; 11; 9(1):198.

    6.Adaha D, Hussain M, Qin L-M, Qin L, Zhang J, Chen X. Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics. Pharmaceutical Research. 2016.05.00.

    7.Qin LM, Yang Y, Liu Q, Xu W, Zhao S, Qin L, Chen X. Down-regulated lncRNA F630028O10Rik contributes to suppress lung cancer in mice through inhibiting miR-223-3p and VEGF signaling pathway (Abstract). Chest. 2016; 150: 261.

    8.Li Z, Liu G, Tong Y, Zhang M, Xu Y, Qin L, Wang Z, Chen X, He J. Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing. Scientific Reports. 2015, 11;5: 10092.

    9. Song H, Hu W, Naowarojna N, Her AS, Wang S, Desai R, Qin L, Chen X, Liu P. Mechanistic studies of a novel C-S lyase in ergothioneine biosyntheses: the involvement of a sulfenic acid intermediate. Scientific Reports. 2015, 7; 5: 11870.

    10.    Meyers MJ, Anderson EJ, McNitt SA, Krenning TM, Singh M, Xu J, Zeng W, Qin L, Xu W, Zhao S, Qin L, Eickhoff CS, Oliva J, Campbell MA, Arnett SD, Prinsen MJ, Griggs DW, Ruminski PG, Goldberg DE, Ding K, Liu X, Tu Z, Tortorella MD3, Sverdrup FM, Chen X. Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents. Bioorg Med Chem. 2015, 15; 23 (16): 5144-50.

    11.    Qin L, Qin L, Xu W, Zhao S, Chen X. Ritonavir-boosted indinavir but not lopinavir inhibits erythrocytic stage Plasmodium knowlesi malaria in rhesus macaques. Bioorg Med Chem Lett. 2015, 1; 25 (7): 1538-40.

    12.    Zhan XY, Wang N, Liu G, Qin L, Xu W, Zhao S, Qin L, Chen X. Plasmodium infection reduces the volume of the viral reservoir in SIV-infected rhesus macaques receiving antiretroviral therapy. Retrovirology. 2014, 9; 11 (1): 112.

    13.    Hu W, Song H, Sae Her A, Bak DW, Naowarojna N, Elliott SJ, Qin L, Chen X, Liu P. Bioinformatic and biochemical characterizations of C-S bond formation and cleavage enzymes in the fungus Neurospora crassa ergothioneine biosynthetic pathway. Org Lett. 2014, 17; 16 (20): 5382-5

    14.    Meyers MJ, Tortorella MD, Xu J, Qin L, He Z, Lang X, Zeng W, Xu W, Qin L, Prinsen MJ, Sverdrup FM, Eickhoff CS, Griggs DW, Oliva J, Ruminski PG, Jacobsen EJ, Campbell MA, Wood DC, Goldberg DE, Liu X, Lu Y, Lu X, Tu Z, Lu X, Ding K, Chen X. Evaluation of aminohydantoins as a novel class of antimalarial agents. ACS Med Chem Lett. 2013, 6; 5 (1): 89-93.

    15.    Ru R, Yao Y , Yu S, Yin B, Xu W, Zhao S, Qin L and Chen X. Targeted genome engineering in human induced pluripotent stem cells by penetrating TALENs. Cell Regeneration. 2013, 2:5  doi:10.1186/2045-9769-2-5

    16.    Yao Y, Nashun B, Zhou T, Qin L, Qin L, Zhao S, Xu J, Esteban M, Chen X. Generation of CD34+ Cells from CCR5-disrupted Human Embryonic and Induced Pluripotent Stem Cells. Human Gene Therapy. 2012, 23: 238-242.

    17.    Li Q, Ruan Z, Zhang H, Peng N, Zhao S, Qin L, Chen X. Characterization of peripheral blood T lymphocyte subsets in Chinese rhesus macaques with repeated or long-term infection with Plasmodium cynomolgi. Parasitol Res. 2012, 110 (2): 961-9.

    18.    Chen L, He Z, Qin L, Li Q, Shi X, Zhao S,Chen L, Zhong N, Chen X. Antitumor effect of malaria parasite infection in a murine Lewis lung cancer model through induction of innate and adaptive immunity. PLoS ONE. 2011, 6 (9): e24407.

    19.    Li X, He Z, Chen L, Li Y, Li Q, Zhao S, Tao Z, Hu W, Qin L, Chen X. Synergy of the antiretroviral protease inhibitor indinavir and chloroquine against malaria parasites in vitro and in vivo. Parasitol Res. 2011; 109: 1519-1524.

    20.    Wang B, Li Q, Qin L, Zhao S, Wang J, Chen X. Transition of tumor-associated macrophages from MHC class IIhi to MHC class IIlow mediates tumor progression in mice. BMC Immunol. 2011; 12: 43.

    21.    Li Y, Qin L, Peng N, Liu G, Zhao S, He Z, Chen X. The Antimalarial effect of human immunodeficiency virus protease inhibitors in rhesus macaques. Antimicrob Agents Chemother. 2011, 55: 3039-42.

    22.    Jiang B, Qin L, Du Y, Peng N, Chen L, Chen Z, Chen X. Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites. Vaccine. 2010, 28: 7915-7922

    23.    You J, He Z, Chen L, Deng G, Liu W, Qin L, Qiu F and Chen X. CH05-10, a novel indinavir analog, is a broad spectrum antitumor agent that induces cell cycle arrest, apoptosis, endoplasmic reticulum stress and autophagy. Cancer Science. 2010; 101:2644-51.

    24.    Xu L, He Z, Xue J, Chen X, Wei X. Beta-Resorcylic acid lactones from a Paecilomyces fungus. J Nat Prod. 2010; 73:885-9.

    25.    You J, Dai H, Chen Z, Liu G, He Z, Song F, Yang X, Fu H, Zhang L, Chen X. Trichoderone, a novel cytotoxic cyclopentenone and cholesta-7,22-diene-3b, 5a, 6b-triol, with new activities from the marine-derived fungus Trichoderma sp. J Ind Microbiol Biotechnol. 2010; 37:245-52.

    26.    He Z, Chen L, You J, Li Y, Zhao S, Qin L and Chen X. In vitro interaction between antiretroviral protease inhibitors and artemisinin endoperoxides against Plasmodium falciparum. International Journal of Antimicrobial Agents. 2010; 35:191-193.

    27.    He Z, Chen L, You J, Qin L, Chen X. Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism. Experimental Parasitology, 2009; 123:122-127.

    28.    Shi X, Qin L, Liu G, Zhao S, Peng N, Chen X. Dynamic balance of pSTAT1 and pSTAT3 in C57BL/6 mice infected with lethal or non-lethal Plasmodium yoelii. Cell Mol Immunol, 2008; 5:341-348.

    29.    He Z, Qin L, Chen L, Peng N, You J and Chen X. Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo. Antimicro Agents Chemother. 2008; 52: 2653-56.

    30.    Zhang L, Yan K, Zhang Y, Huang R, Bian J, Zheng C, Sun H, Chen Z, Sun N, An  R, Min F, Zhao W, Zhuo Y, You J, Song Y, Yu Z, Liu Z, Yang K, Gao H, Dai H, Zhang X, Wang J, Fu C, Pei G, Liu J, Zhang S, Goodfellow M, Jiang Y, Kuai J, Zhou G and Chen X.  High-throughput synergy screening identifies beauvericin as a novel combination agent for the treatment of fungal infections. Proc Natl Acad Sci USA. 2007; 104:4606-4611.