首页 >> 中文 >> 专家人才

专家人才

  • 姓名: 何俊
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: he_jun@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历:

  • 2018             中科院广州生物医药与健康研究院 研究员

    2016-2018   Senior Scientist, UCB Pharma

    2013-2016    Post-doctoral Research Fellow, the Francis Crick Institute. Supervisor: Dr. John Diffley, FRS

    2012-2013   Post-doctoral Scientist, The Institute of Cancer Research, London. Supervisor: Dr David Barford, FRS      

    2008-2012    PhD at The Institute of Cancer Research, London. Supervisors: Dr David Barford FRS and Dr Ed Morris

    2002-2006   理学学士 清华大学 生物科学

    研究领域:

  • 综合低温冷冻电镜技术和X射线晶体学技术等多种结构生物学研究手段,在多尺度上来研究生物系统的高分辨率构造。主要研究方向为调控细胞命运调控因子的结构与功能的关系,以及细胞命运转变分子机制的探索。

    承担科研项目情况:

  •  

    社会任职:

  •  

    获奖及荣誉:

  • 2013      Chairman’s Prize for Best PhD, the Institute of Cancer Research

    2012      Chinese Government Award for outstanding students abroad 

    代表论著:

  • Frigola, J.*, He, J.*, Kinkeilin, K., Pye, V., Renault, L., Douglas, M., Remus, D., Cherepanov, P., Costa, A., Diffley, J.F.X. (2017). Cdt1 stabilises an open MCM ring for helicase loading. Nat. Commun, 8, 15720.

    He, J.*, Chao, W.C.*, Zhang, Z., Yang, J., Cronin, N., & Barford, D. (2013). Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Molecular cell, 50(5):649-60.

    da Fonseca, P. C., He, J., & Morris, E. P. (2012). Molecular model of the human 26S proteasome. Molecular cell, 46(1), 54-66.

    He, J.*, Kulkarni, K.*, da Fonseca, P. C., Krutauz, D., Glickman, M. H., Barford, D., & Morris, E. P. (2012). The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings. Structure, 20(3), 513-521.