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专家人才

  • 姓名: 王建华
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: wang_jianhua@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历:

  • 教育经历

    河南大学, 1995.9-1999.7, 大学本科,生物学

    中科院昆明动物研究所, 1999.9-2005.7, -博研究生,病毒学

    工作经历:

    美国威斯康星州医学院,2005.9-2009.3,博士后,病毒学

    中科院上海巴斯德研究所,2009.3-2020.3,研究员,课题组长,病毒学

    中科院广州生物医药与健康研究院,2020.3-今,研究员,课题组长,病毒学

     

    研究领域:

  • 主要从事新发、再发重大传染性疾病防控的应用基础研究。主要研究包括艾滋病病毒、新发再发重大传染病病原的感染免疫和致病机制,探索新的抗病原策略。

    承担科研项目情况:

  • 国家自然科学基金面上,HIV潜伏感染人源化小鼠模型的建立及在潜伏激活剂功能评价中的应用;

    科技部艾滋病和病毒性肝炎重大传染病专项,HIV病毒潜伏库清除新策略研究;

    中国科学院前沿科学重点研究项目,艾滋病病毒潜伏感染机制及治疗策略研究;

    国家自然科学基金-NIH联合项目,HIV-1 Nef蛋白与宿主蛋白Naf1相互作用调控病毒潜伏感染.

    社会任职:

  •    《Virology Journal, Associate Editor

    获奖及荣誉:

    • 2016,上海市科技系统青年五四奖章;
      2014,云南省科技技术进步奖三等(排名第三);
      2014,云南省卫生科技成果一等奖(排名第二)
      2013,中科院“朱李月华优秀教师奖”;
      2011,上海市启明星计划(A 类);
      2010,赛诺菲-安万特-中国科学院上海生命科学研究院优秀青年人才奖;

    代表论著:

  •      1)   Fan TJ, Sun L, Yang XG, Jin X, Sun WW*, Wang JH*. The Establishment of an in vivo HIV-1 Infection Model in Humanized B-NSG Mice. Virolocia Sinica, 2019.  PMID: 31863357.

    2) Zhou YH, Sun L, Chen J, Sun WW, Ma L, Han Y, Jin X, Zhao QX, Li T, Lu H, Qiu X*, Wang JH*. Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway to Promote HIV-1 Infection and Reactivation. mBio, 2019. PMID:31848275.

    3) Qu D, Sun WW, Li L, Ma L, Sun L, Jin X, Li T*, Hou W*, Wang JH*. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter. Nucleic Acids Res, 2019, PMID: 30788509.

    4)  Li Y, Fu X, Ma J, Zhang J, Hu Y, Dong W, Wan Z, Li Q, Kuang YQ, Lan K, Jin X, Wang JH*, Zhang C*. Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children. Nat Commun, 2019, PMID:31123265

    5)  Sun WW, Jiao S, Sun L, Zhou Z, Jin X, Wang JH*. SUN2 modulates HIV-1 infection and latency through association with lamin A/C to maintain the repressive chromatin. mBio, 2018. PMID: 29717016.

    6)  Li C, Wang HB, Kuang WD, Ren XX, Song ST, Zhu HZ, Li Q, Xu LR, Guo HJ, Wu L*, Wang JH*. Naf1 regulates HIV-1 latency by suppressing viral promoter-driven gene expression in primary CD4+ T cells. J Virol. 2017, PMID:27795436.

    7) Jiang AP, Jiang JF, Wei JF, Guo MG, Qin Y, Guo QQ, Ma L, Liu BC, Wang X, Veazey RS, Ding YB*, Wang JH*. Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol. 2015. PMID:26719250

    8) Jiang AP, Jiang JF, Guo MG, Jin YM, Li YY, Wang JH*. Human blood circulating basophils capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol. 2015. PMID:26018157

    9)  Ma L, Sun L, Jin X, Xiong SD, Wang JH*.  Scaffold attachment factor B suppresses HIV-1 infection of CD4+ cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat. J Bio. Chem. 2018.  PMID: 29887524.

    10)  Ren XX, Wang HB, Li C, Jiang JF, Xiong SD, Jin X, Wu L, Wang JH*. HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA. J Bio. Chem. 2016. PMID:26733199

    11) Qian YW, Li C, Jiang AP, Ge S, Gu P, Fan X, Li TS, Jin X, Wang JH*, Wang ZL*. HIV-1 gp120 glycoprotein interacting with dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) down-regulates tight junction proteins to disrupt the blood retinal barrier and increase its permeability. J Bio. Chem. 2016.  PMID: 27605665.

    12) Shen CJ, Jia YH, Tian RR, Ding M, Zhang C, Wang JH*. Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection. FASEB J, 2012; PMID 22835829.

    13)  Ren XX, Ma L, Sun WW, Kuang WD, Li TS, Jin X, Wang JH*. Dendritic cells maturated by co-culturing with HIV-1 latently infected Jurkat T cells or stimulating with AIDS-associated pathogens secrete TNF-alpha to reactivate HIV-1 from latency. Virulence, 2017. PMID: 28762683

    14)  Kuang WD, Zhou YH, Zhong P, Zhang C, Wang JH*. Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV-1 CRF01_AE to downmodulate CD4. J Med Virol. 2017. PMID: 28500742.

    15) Ren XX, Li C, Xiong SD, Huang Z, Wang JH*, Wang HB*. Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death. Virulence. 2015. PMID: 26399965.

    16) Zhang Y, Li SK, Yi Yang K, Liu M, Lee N, Tang X, Wang H, Liu L, Chen Z, Zhang C, Wang J*, Kwok-Wing Tsui S*. Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1. Sci Rep. 2015. 5:10806. PMID: 26039376

    17) Yang FC, Kuang WD, Li C, Sun WW, Qu D, Wang JH*. Toll-Interacting Protein Suppresses HIV-1 Long-Terminal-Repeat-Driven Gene Expression and Silences the Post-Integrational Transcription of Viral Proviral DNA. PLoS ONE, 2015; PMID: 25915421

    18) Ma L, Shen CJ, Cohen E, Xiong SD, Wang JH*. MiRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP. PLoS ONE, 2014; PMID: 24932481.

    19) Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF*, Wang JH*. Histamine enhances HIV-1-induced modulation of dendritic cells to skew na?ve T cell differentiation toward regulatory T cells. Virology, 2013; PMID 23652320.

    20)  Liu W, Qin Y, Bai L, Lan K, Wang JH*. Kaposi's-sarcoma -associated-herpesvirus -activated dendritic cells promote HIV-1 trans-infection and suppress CD4+ T cell proliferation. Virology, 2013; PMID23510674.

    21) Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K*, Wang JH*. Penicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells. PLoS One. 2011; PMID 22110688.

    22) Qin Y, Li Y Y, Jiang A P, Jiang J F, Wang JH*. Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection. Biochem Biophys Res Commun; 2012; PMID 22704932.

    23) Tian RR, Guo HX, Wei JF, Yang CK, He SH*, Wang JH*. IFN-lambda inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production. Antiviral Res. 2012; PMID: 22584351.

    24) Ji H, Jiang Z, Lu P, Ma L, Li C, Pan H, Fu Z, Qu X, Wang P, Deng J, Yang X, Wang J, Zhu H. Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter. Mol Ther. 2016. PMID:26775808

    25) Qu X, Wang P, Ding D, Li L, Wang H, Ma L, Zhou X, Liu S, Lin S, Wang X, Zhang G, Liu S, Liu L, Wang J, Zhang F, Lu D, Zhu H. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res, 2013; PMID: 23804764.

    26)  Ren XX, Ma L, Liu QW, Li C, Huang Z, Wu L, Xiong SD, Wang JH, Wang HB. The molecule of DC-SIGN captures enterovirus 71 and confers dendritic cell-mediated viral trans-infection. Virol J. 2014; PMID: 24620896.

    27)  St Gelais C, Coleman CM, Wang JH, Wu L. HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation. PLoS One. 2012; PMID: 22479639.

    28) Zhang C, de Silva S, Wang JH, Wu L. Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor. PLoS One. 2012; PMID: 22574228.

    29)  Li S K, Leung R K, Guo H X, Wei J F, Wang JH, Kwong K T, Lee S S, Zhang C, and Tsui S K. Detection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults. Clin Microbiol Infect. 2012PMID: 22084916.

    30)  Liu J, Chen K, Wang JH, and Zhang C. Molecular evolution of the primate antiviral restriction factor tetherin. PLoS One. 2010; PMID: 20689591.

    31) Guo D, Ding N, Xu Y, Guo H, Wei J F, Wang JH, He G, Yang R, and Zhang C.  Near full-length genome characterization of an HIV-1 CRF01_AE strain in Jiangsu, China: evidence of two independent introductions from Fujian. AIDS Res Hum Retroviruses, 2009; PMID: 19534629.