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专家人才

  • 姓名: 孔祥谦
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: kong_xiangqian@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历:

  • 20059-20097    山东大学药学院, 学士

    20099-20147    中科院上海药物研究所药物设计专业,博士

    20152-20207     The Johns Hopkins University School of Medicine,博士后

    20208月至今                 中科院广州生物医药与健康研究院化学生物学所,研究员

    研究领域:

  •  

    1.肿瘤转录异常关键靶标的动态结构-致癌功能关系研究

     

    2.靶向致癌表观遗传调节蛋白和谱系特异性致癌转录因子的创新药物发现

     

    3.现有表观遗传药物在肿瘤和遗传性疾病治疗中的精准应用

    承担科研项目情况:

    社会任职:

  • 美国癌症研究协会(AACR) 会员

    获奖及荣誉:

  • 2019  AACR-Get Your Rear in Gear Philadelphia Scholar in Training Award 

    2015  上海市研究生优秀学位论文 

    2012  中科院研究生国家奖学金 

    2011  中国科学院大学三好学生 

    代表论著:

  • 1.      Kong X#, Chen J#, Xie W#, Brown S, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann R, Tao Y, Yen R, Topper MJ, Easwaran H, Rothbart SB*, Xia L*, Baylin SB*, Defining UHRF1 Domains That Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, Cancer Cell. 2019;35(4):633-648

    2.      Kong X#, Liu J#, Li L, Yue L, Zhang L, Jiang H, Xie X*, Luo C*, Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition, Nucleic Acids Res. 2015;43(9):4381-92

    3.      Kong X#, Chen L#, Jiao L, Jiang X, Lian F, Lu J, Zhu K, Du D, Liu J, Ding H, Zhang N, Shen J, Zheng M, Chen K, Liu X, Jiang H, Luo C*. Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2, J Med Chem. 2014;57(22):9512-21

    4.      Ye F#, Kong X#, Zhang H, Liu Y, Shao Z, Jin J, Cai Y, Zhang R, Li L, Zhang YW, Liu YC, Zhang C, Xie W, Yu K, Ding H, Zhao K, Chen S, Jiang H*, Baylin SB*, Luo C*. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, ACS Chem Biol. 2018;13(3):772-781

    5.      Zhu M#, Du D#, Hu J, Li L, Liu J, Ding H, Kong X*, Jiang H, Chen K, Luo C*, Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors, Acta Pharmacol Sin. 2018;39(2):302-310 co-corresponding

    6.      Kong X#, Qin J#, Li Z#, Vultur A, Tong L, Feng E, Rajan G, Liu S, Lu J, Liang Z, Zheng M, Zhu W, Jiang H, Herlyn M, Liu H, Marmorstein R*, Luo C*., Development of a novel class of B-RafV600E-selective inhibitors through virtual screening and hierarchical hit optimization, Organ Biomol Chem, 2012;10:7402-17

    7.      Lu J#, Kong X#, Luo C*, Li KK*. Application of Epigenome-Modifying Small Molecules in Induced Pluripotent Stem Cells, Med Res Rev, 2012, May 11, DOI:10.1002/med.21265

    8.      Kong X#, Ouyang S#, Liang Z, Lu J, Chen L, Shen B, Li D, Zheng M, Li KK*, Luo C*, Jiang H., Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A computational study, PLoS ONE, 2011; 6(9): e25444

    9.      Chen L#, Kong X#, Liang Z, Ye F, Yu K, Dai W, Wu D*, Luo C*, Jiang H, Theoretical study of the mechanism of proton transfer in the esterase EstB from Burkholderia gladioli, J Phys Chem B, 2011;115 (44), 13019-13025