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专家人才

  • 姓名： 李黎
  • 性别： 女
  • 职称： 副研究员
  • 学历： 博士
  • 电话： 
  • 传真： 
  • 电子邮件: li_li@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历：

  • 2022.09-至今，中科院广州生物医药与健康研究院，副研究员

    2022.01-2022.08，广州国家实验室，助理研究员

    2020.09-2021.12，生物岛实验室，助理研究员

    2017.09-2020.08，南方医科大学珠江医院，博士后

    2012.09-2017.07，中科院广州生物医药与健康研究院，博士

    研究领域：

  • 基因编辑与疾病动物模型的构建及治疗

    单细胞多组学解析疾病发生及细胞命运调控机制

    承担科研项目情况：

  • 1.国家自然科学青年基金项目：利用 TMP蛋白调控系统和CRISPR基因编辑技术制作快速可逆诱导型肝损伤猪模型、81800555、2019/01-2021/12、项目负责人

    2.广州市科技计划项目：Zswim4蛋白在骨细胞感知机械刺激及骨再生中的功能和机制研究、202201011037、2022/04-2024/03、项目负责人

    3.国家重点研发计划：基于hiHep/HepGL细胞和ZhJ-III装置的混合型人工肝系统的构建与开发、2018YFC1106400、2018/09-2021/06、项目参与者

    社会任职：

    获奖及荣誉：

    代表论著：

  • 1. Li L, Meng H, Zhang J, Liu Y, Zou Q, Gao Y, Yang H, Lai L. A tunable, rapid and precision drug control of protein expression by combining transcriptional and post-translational regulation system. J Genet Genomics. 2020 Nov 20;47(11):705-712.

    2. Li L, Meng H, Zou Q, Zhang J, Cai L, Yang B, Weng J, Lai L, Yang H, Gao Y. Establishment of gene-edited pigs expressing human blood-coagulation factor VII and albumin for bioartificial liver use. J Gastroenterol Hepatol. 2019 Oct;34(10):1851-1859.

    3. Li L, Zhang Q, Yang H, Zou Q, Lai C, Zhao Ping, Luo Z, Yang J, Chen Q, Wang Y, Newsome P, Frampton J, Maxwell P. H., Siu T, Tam S, Tse H, Qin B, Bao X, Esteban M*, and Lai L*. Fumarylacetoacetate hydrolase knockout rabbit model for hereditary tyrosinemia type 1. JBC. 2017 Mar 17;292(11):4755-4763.

    4. Li N, Gou SX, Wang JW, Zhang QJ, Huang XY, Xie JK, Li L, Jin Q, Ouyang Z, Chen FB, Ge WK, Shi H, Liang YH, Zhuang ZP, Zhao XZ, Lian M, Ye YH, Quan LQ, Wu H, Lai LX, Wang KP. CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I. Molecular Therapy. 2021 Mar 3;29(3):1001-1015.

    5. Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai C, Yang H, Li L, Liu Q, Shi H, Xu G, Zhao H, Wei H, Pei Z, Li S, Lai L, Li XJ. A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease. Cell. 2018 May 3;173(4):989-1002.e13.

    6. Yang J, Wang Y, Zhou T, Wong LY, Tian XY, Hong X, Lai WH, Au KW, Wei R, Liu Y, Cheng LH, Liang G, Huang Z, Fan W, Zhao P, Wang X, Iba？ez DP, Luo Z, Li Y, Zhong X, Chen S, Wang D, Li L, Lai L, Qin B, Bao X, Hutchins AP, Siu CW, Huang Y, Esteban MA, Tse HF. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Mar 14;8(3):605-618.                    

    7. Wei S, Zou Q, Lai S, Zhang Q, Li L, Yan Q, Zhou X, Zhong H, Lai L. Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Scientific Reports. 2016 Jan 19;6:19648.

    8. Lai S, Wei S, Zhao B, Ouyang Z, Zhang Q, Fan N, Liu Z, Zhao Y, Yan Q, Zhou X, Li L, Xin J, Zeng Y, Lai L, Zou Q. Generation of Knock-In Pigs Carrying Oct4-tdTomato Reporter through CRISPR/Cas9-Mediated Genome Engineering. PLoS One. 2016 Jan 12;11(1):e0146562.

    9. Zou Q, Wang X, Liu Y, Ouyang Z, Long H, Wei S, Xin J, Zhao B, Lai S, Shen J, Ni Q,Yang H, Zhong H, Li L, Hu M, Zhang Q, Zhou Z, He J, Yan Q, Fan N, Zhao Y, Liu Z, Guo L, Huang J, Zhang G, Ying J, Lai L, Gao X. Generation of gene-targeted dogs using CRISPR/Cas9 system. J Mol Cell Biol. 2015 Dec;7(6):580-583.

    10. Wang Y, Fan N, Song J, Zhong J, Guo X, Tian W, Zhang Q, Cui F, Li L, Newsome PN, Frampton J, Esteban MA, Lai L. Generation of knockout rabbits using transcription activator-like effector nucleases. Cell Regen (Lond). 2014 Feb 5;3(1):3.