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专家人才

  • 姓名: 孙昊
  • 性别: 男
  • 职称: 副研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: sun_hao@gibh.ac.cn
  • 通讯地址 广州市黄埔区开源大道190号

    简历:

  • 2004-92009-6, 河北农业大学学士

    2010-92013-6, 北京林业大学硕士

    2013-92017-8, 中国科学院广州生物医药与健康研究院助理研究员

    2017-92020-6, 中国科学院大学博士

    2020-72022-7, 生物岛实验室,  副研究员

    2022-8至今中国科学院广州生物医药与健康研究院,  副研究员

    研究领域:

  • 早期胚胎发育过程中的细胞命运与决定

    表观遗传学变化的机制研究

    承担科研项目情况:

  • 国家自然科学基金青年基金     1/主持)

    广州市基础与应用基础研究项目 (1/主持)

    国家重点研发计划             1/项目骨干)

    社会任职:

    获奖及荣誉:

    代表论著:

  • 1.       Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H#, Zheng H#. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. FASEB J. 2020 Apr;34(4):5917-5930. doi: 10.1096/fj.201902873R. Epub 2020 Mar 10. PMID: 32154623. 共同通讯作者

    2.       Sun H, Yang X, Liang L, Zhang M, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D, Zheng H. Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency. EMBO J. 2020 Apr 15;39(8):e102961. doi: 10.15252/embj.2019102961. Epub 2020 Feb 24. PMID: 32090361; PMCID: PMC7156961.

    3.       He S, Wang F, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Pang H, Li Y, Huang X, Qin D, Pei D, Sun H, Zheng H. Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming. Cell Discov. 2019 Feb 12;5:11. doi: 10.1038/s41421-018-0074-6. PMID: 30774978; PMCID: PMC6370818. 共同通讯作者

    4.       He S, Sun H, Lin L, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Wang X, Wang F, Zhu F, Chen J, Pei D, Zheng H. Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells. J Biol Chem. 2017 Nov 10;292(45):18542-18555. doi: 10.1074/jbc.M117.810457. Epub 2017 Sep 18. PMID: 28924038; PMCID: PMC5682964.共同第一作者

    5.       Sun H, Liang L, Li Y, Feng C, Li L, Zhang Y, He S, Pei D, Guo Y, Zheng H. Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch. Sci Rep. 2016 Aug 2;6:30903. doi: 10.1038/srep30903. PMID: 27481483; PMCID: PMC4969595.

    6.       Liang L, Sun H, Zhang W, Zhang M, Yang X, Kuang R, Zheng H. Meta-Analysis of EMT Datasets Reveals Different Types of EMT. PLoS One. 2016 Jun 3;11(6):e0156839. doi: 10.1371/journal.pone.0156839. PMID: 27258544; PMCID: PMC4892621. 共同第一作者

    7.       Zou Y, Zhang J, Xu J, Fu L, Xu Y, Wang X, Li Z, Zhu L, Sun H, Zheng H, Guo J. SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages. Cell Biosci. 2021 Dec 14;11(1):210. doi: 10.1186/s13578-021-00725-y. PMID: 34906231; PMCID: PMC8672560.

    8.       Liu J, Li L, Zou Y, Fu L, Ma X, Zhang H, Xu Y, Xu J, Zhang J, Li M, Hu X, Li Z, Wang X, Sun H, Zheng H, Zhu L, Guo J. Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury. Neural Regen Res. 2022 Mar;17(3):673-681. doi: 10.4103/1673-5374.320997. PMID: 34380909; PMCID: PMC8504388.

    9.       Zhang M, Li Q, Yang T, Meng F, Lai X, Liang L, Li C, Sun H, Sun J, Zheng H. Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming. Cell Regen. 2020 Oct 1;9(1):17. doi: 10.1186/s13619-020-00057-1. PMID: 33000315; PMCID: PMC7527398.

    10.    Meng F, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L, Zheng H. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cell Mol Neurobiol. 2021 Jul;41(5):1031-1038. doi: 10.1007/s10571-020-00970-8. Epub 2020 Sep 28. PMID: 32989585.

    11.    Liang L, Chen J, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H. Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway. Cell Rep. 2020 Mar 17;30(11):3625-3631.e6. doi: 10.1016/j.celrep.2020.02.075. PMID: 32187535.

    12.    Lin L, Liang L, Yang X, Sun H, Li Y, Pei D, Zheng H. The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming. J Biol Chem. 2018 Sep 21;293(38):14905-14915. doi: 10.1074/jbc.RA118.003913. Epub 2018 Aug 10. PMID: 30097516; PMCID: PMC6153288.

    13.    He S, Chen J, Zhang Y, Zhang M, Yang X, Li Y, Sun H, Lin L, Fan K, Liang L, Feng C, Wang F, Zhang X, Guo Y, Pei D, Zheng H. Sequential EMT-MET induces neuronal conversion through Sox2. Cell Discov. 2017 May 30;3:17017. doi: 10.1038/celldisc.2017.17. PMID: 28580167; PMCID: PMC5450022.

    14.    Huang Z, Liang L, Li L, Xu M, Li X, Sun H, He S, Lin L, Zhang Y, Song Y, Yang M, Luo Y, Loh HH, Law PY, Zheng D, Zheng H. Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels. Lipids Health Dis. 2016 Mar 8;15:47. doi: 10.1186/s12944-016-0212-9. PMID: 26952011; PMCID: PMC4782347.

    15.    He S, Guo Y, Zhang Y, Li Y, Feng C, Li X, Lin L, Guo L, Wang H, Liu C, Zheng Y, Luo C, Liu Q, Wang F, Sun H, Liang L, Li L, Su H, Chen J, Pei D, Zheng H. Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo. Cell Regen. 2015 Dec 30;4:12. doi: 10.1186/s13619-015-0027-6. PMID: 26719791; PMCID: PMC4696146.

    16.    Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D, Zheng H. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol. 2013 Jul;15(7):829-38. doi: 10.1038/ncb2765. Epub 2013 May 26. PMID: 23708003.

     

    专利

    1.       郑辉; 李文; 何松蔚; 孙昊; 纳络酮用于制备提高空间学习记忆能力的药物中的应用, 2016-8-24, 中国, ZL201410393385.2.