题目：To cut or not to cut, that’s the question: How the CRISPR-Cas12a RNA-guided endonuclease cleaves its target DNA
主讲人：Prof. Guillermo Montoya, University of Copenhagen, Director of the Protein Structure & Function Programme
Guillermo Montoya is Full-Professor at the University of Copenhagen (UCPH), elected EMBO member. Montoya is also the Chairman of ISBUC, the Integrative Structural Biology Cluster at UCPH. In the last years, his main research interests are the structural analysis of macromolecular complexes, such as the mammalian chaperonin CCT complex, where he uses a combination of X-ray crystallography and electron microscopy to gain insight about their working mechanisms. Dr. Montoya is also systematically pursuing the structure-function analysis of endonucleases, which are of great interest because of their potential applications in gene therapy. Recently He has solved the structure of a new CRISPR-Cas member, Cpf1, which can open new avenues in genome modification. He is member of international project evaluation panels and also reviews projects for European funding agencies (ERC, EU, SNF, DFG, ANR, NOW, MINECO, Welcome Trust, Vinnova) and serves as an associate editor and ad-hoc reviewer for high profile journals. In addition, his group has been the receptor of Marie Curie, EMBO and HFSP postdoctoral fellows. He is as responsible author out of 135 peer reviewed articles in international journals of the Structural Molecular Biology Area including Cell, Nature, PANS.