学术活动
10月18日广州生物院学术讲座预告
题目：Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming
主讲人：陈可实 副研究员
时间：2019年10月18日 15：30
地点：第一会议室A430
主持人：郭宜平 副研究员
Achievement introduction: Chromatin relaxation is required for generation of pluripotent stem cells, but how factor‐dependent chromatin opening is instructed remains poorly understood. Here, epigenetic profiling reveals Oct4 as a pioneer factor that loosens heterochromatin and cooperates with Klf4 and other chromatin remodellers during reprogramming.