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导师介绍

蒋 晟 博士 中国科学院广州生物医药与健康研究院研究员

发表日期:2008-03-03来源:放大 缩小
 
研究兴趣
        
课题组的研究方向和研究兴趣包括:
 
1. 针对特定致病基因的活性小分子和多肽化合物的合理设计、合成和构效关系研究。
2. 具有抗肿瘤活性天然产物的全合成及新的先导药物的发现。   
     联系方式:jiang_sheng@gibh.ac.cn 

 

教育
  • 2000,9 ~ 2003,7  中科院上海有机化学研究所,有机化学,博士
  • 1997,9~ 2000,7    中国药科大学,药物化学,硕士 
  • 1993,9 ~ 1997,7   中国药科大学,药物化学,本科
专业工作经历
  • 2007 ~ ,               中国科学院广州生物医药与健康研究院 
  • 2003~ 2007   美国国立卫生研究院国家癌症研究所(NIH, NCI),博士后
论文发表选录
  1. S. Jiang, P. Li, S. L. Lee, C. Y. Lin, Y.Q Long, M. D. Johnson, R. B. Dickson, P. P. RollerDesign and Synthesis of redox stable analogues of Sunflower Trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of MatriptaseOrgainc. Lett. 2007. 9, 9-12.
  2. P. Li, S. Jiang, S. L. Lee, C. Y. Lin, M. D. Johnson, R. B. Dickson, C. J. Michejda, P. P. RollerDesign and Synthesis of Novel and Potent Inhibitors of the Type II Transmembrane Serine Protease, Matriptase, Based upon the Sunflower Trypsin Inhibitor-1J. Med. Chem. 2007. 50, 5976-5983.
  3. H. Sun, Z. Nikolovska-Coleska, J. Lu, J. Meagher, C. Yang, S. Qiu, Y. Tomita, Y. Ueda, S. Jiang, Krajewski, P. P. Roller, J. A. Stuckey, S. WangDesign, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAPJ. Am. Chem. Soc. 2007. 129, 15279-15294.
  4. S. Jiang, Y. Li, X. G. Chen, T. S. Hu, Y. L. Wu, Z.-J.Yao.Parallel fragment assembly strategy towards multiple-ether mimicry of anticancer annonaceous acetogenins.Angew. Chem. Int. Ed. 2004, 43, 329-334.
  5. S. Jiang, Z. Liu, G. Sheng, B. B. Zeng, X. G. Cheng, Y.-L. Wu, Z.-J.Yao.Mimicking of Annonaceous Acetogenins: Enantionselective Synthesis of a (4R)-Hydroxy Analog Having Potent Antitumor Activity.  J. Org. Chem, 2002, 67, 3404-3408.
专利情况
  1. Z-J.Yao, Y.-L. Wu, S. Jiang. Synthesis and application of ether bond modified chiral annonaceous acetogenins compound.     
  2. Faming Zhuanli Shenqing Gongkai Shuomingshu. 2004, 19 (CN1477103). 
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