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专家人才

  • 姓名: 李志远
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: li_zhiyuan@gibh.ac.cn
  • 通讯地址 广州萝岗区科学城开源大道190号

    简历:

    • 1997年获中南大学药理学博士学位,并赴日留学
      2000年获得日本德岛大学(Tokushima University)博士学位

    • 2000-2002年 在美国范德堡大学(Vanderbilt University)药理学系从事博士后研究
      2002-2007年 在美国圣路易斯大学(Saint Louis University)医学院从事研究工作,担任助理教授
       

    研究领域:

    • 干细胞的基础研究及临床应用;

      iPS分化而成的神经元离子通道特征研究;

      P2X离子通道的功能研究;

      TRPV在细胞运输及肿瘤调控机制的研究;

      离子通道药物筛选与安全性评估

    承担科研项目情况:

  • 国家自然基金面上项目;

    国家重大科学计划干细胞973计划专项项目;

    广东省科技厅前沿探索项目;

    广东省科技厅产学研合作项目

    社会任职:

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    获奖及荣誉:

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    代表论著:

  • 1.       Li S; Zhao H; Han X; Ni B; He L; Mukama O; Habimana JDD; Lin Z; Huang R; Huang H; Tian C; Tang F; Li Z. (2021) Generation of UCiPSCs-derived neurospheres for cell therapy and its application. Stem Cell Research & Therapy. EMID:c6b60f30551c5c29.

    2.       Liao Z, Yang X, Wang W, Deng W, Zhang Y, Song A, Ni B, Zhao H, Zhang S, Li Z. (2021) hucMSCs transplantation promotes locomotor function recovery, reduces apoptosis and inhibits demyelination after SCI in rats. Neuropeptides. 86 (2021) 102125. 

    3.       Zhao H, Li S, Lin Z, He L, Deng W, Han X, Tang F, Cheng N, Zhou P, Huang R, Deng S, Huang J, Li Z. (2020). A heterozygous SCN1A (c.A5768G/+) mutant human induced pluripotent stem cell line (USTCi002-A) generated using TALEN-mediated precise gene editing. Stem Cell Res. 49, 102058.

    4.       Zhao H, He L, Huang H, Li S, Cheng N, Tang F, Han X, Lin Z, Huang R, Zhou P, Deng S, Huang J, Li Z. (2020). Generation of a tdTomato-GAD67 reporter human epilepsia mutation induced pluripotent stem cell line, USTCi001-A-2, using CRISPR/Cas9 editing. Stem Cell Res. 48:102003

    5.       Zhou P, Xie W, Huang HL, Huang R, Tian C, Zhu H, Dai Y, Li Z. (2020). circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway. Aging (Albany NY). 12(13):13338-13353.

    6.       Cheng N, Liu Y, Mukama O , Han X, Huang H, Li S, Zhou P, Lu X, Li Z. (2020). A signal-enhanced and sensitive lateral flow aptasensor for the rapid detection of PDGF-BB. RSC Adv. 10, 18601.

    7.       Zhao H, He L, Li S, Huang H, Tang F, Han X, Lin Z, Tian C, Huang R, Zhou P, Huang J, Deng S, Li Z. (2020). Generation of corrected-hiPSC (USTCi001-A-1) from epilepsy patient iPSCs using TALEN-mediated editing of the SCN1A gene. Stem Cell Res. 46:101864.

    8.       Tian C, Han X, He L, Tang F, Huang R, Lin Z, Li S, Deng S, Xu J, Huang H, Zhao H, Li Z. (2020). Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. Molecular and cellular biochemistry, 473(1-2):179-192.

    9.       Tian C, Li S, He L, Han X, Tang F, Huang R, Lin Z, Deng S, Xu J, Huang H, Zhao H, Li Z. (2020) Transient receptor potential ankyrin 1 contributes to the lysophosphatidylcholine-induced oxidative stress and cytotoxicity in OLN-93 oligodendrocyte. Cell Stress Chaperones. doi: 10.1007/s12192-020-01131-y.

    10.    Zhao H, Li S, He L, Han X, Huang H, Tang F, Lin Z, Deng S, Tian C, Huang R, Li Z. (2020). Generation of iPSC line (USTCi001-A) from human skin fibroblasts of a patient with epilepsy. Stem Cell Res. 45:101785.

    11.    Tian C, Huang R, Tang F, Lin Z, Cheng N, Han X, Li S, Zhou P, Deng S, Huang H, Zhao H, Xu J, Li Z. (2020). Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation. J Membr Biol. 253(1):43-55.

    12.    He L, Zhao H, Li S, Han X, Chen Z, Wang C , Tian C, Tang F, Huang R, Lin Z, Li Z, Tang B, Jiang H.(2020).Generation of Induced Pluripotent Stem Cell Line (CSUXHi002-A) From a Patient With Spinocerebellar Ataxia Type 1. Stem Cell Res. 45:101816.

    13.    Mukama O, Yuan T, He Z, Li Z, Habimana J, Hussain M, Li W, Yi Z, Liang Q, Zeng L.(2020).A high fidelity CRISPR/Cas12a based lateral flow biosensor for the detection of HPV16 and HPV18. Sensors and Actuators B: Chemical. 316: 128119.

    14.    Mukama O, Wu j, Li Z, Liang Q, Yi Z, Lu X, Liu Y, Liu Y, Hussain M, Makafe G, Liu J, Xu N, Zeng L.(2020).An ultrasensitive and specific point-of-care CRISPR/Cas12 based lateral flow biosensor for the rapid detection of nucleic acids. Biosensors and Bioelectronics. 159: 112143.

    15.    Huang H , Li C, Ma W, Yin S, Zhao H, Deng S, Shu X, Wu D, Liu D, Huang R, Cheng N, Huang J, Li Z. (2019). Sorting Nexin 11 (SNX11) Knockout Mice Exhibit Enhanced Thermosensing Behaviour. Genes Brain and Behavior. e12625.

    16.    He L, Ye W, Chen Z, Wang C, Zhao H, Li S, Peng L, Han X, Zhou T, Li Z, Tang B, Jiang H. (2019) Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3. Stem Cell Res. 40:101555.

    17.    Li S, Zhao H, Huang R, He L, Tian C, Huang H, Han B, Tang F, Lin Z, Deng S, Zhou J, Li Z. (2019). Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder. Stem Cell Res. 40, 101571.

    18.    Huang R, Wang F, Yang Y, Ma W, Lin Z, Cheng N, Long Y, Deng S, Li Z. (2019) Recurrent activations of transient receptor potential vanilloid-1 and vanilloid-4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells. FEBS Open Bio. 18;9(2):206-225.

    19.    Wang F, Cheng N, Chen J, Yang Y, Huang R, Huang H, Lin Z, Tian C, Zhao H, Long Y, Li Z. (2019) Promoting Osteogenesis of Human Umbilical Cord Mesenchymal Stem Cells Using 1α, 25-(OH)2D3 to Change Intracellular Calcium Concentration. J Nanosci. Nanotechnol. 19(9):5435-5440.

    20.    Ji S, Lin S, Chen J, Huang X, Wei C, Tang S, Li Z. (2018) Neuroprotection of Transplanting Human Umbilical Cord Mesenchymal Stem Cells in a Microbead Induced Ocular Hypertension Rat Model. Current Eye Research. 1460-2202

    21.    Lei Y, Chen C, Yan X, Li Z, Deng X. (2017) Early-life lipopolysaccharide exposure potentiates forebrain expression of NLRP3 inflammasome proteins and anxiety-like behavior in adolescent rats. Brain Research. 15;1671:43-54.

    22.    Zhong X, Deng S, Ma W, Yang Y, Lu D, Cheng N, Chen D, Wang H, Zhang J, Li F, Li C, Huang H, Li Z. (2017) Anterior cingulate cortex involved in social food-foraging decision-making strategies of rats. Brain Behav. 7(10):e00768.

    23.    Li C, Ma W, Yin S, Liang X, Shu X, Pei D, Egan TM, Huang J, Pan A, Li Z. (2016) Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3. Traffic. 17(5):500-14.

    24.    Liu J, Gao C, Chen W, Ma W, Deng S, Li X, Shi Y, Zhang H, Zhang L, Long Y, Xu H, Guo X, Lai L, Pan G, Chen Y, Liao W, Li Z (2016) CRISPR/Cas9 Facilitates Investigation of Neural Circuit Disease using Human iPSCs: Mechanism of Epilepsy Caused by an SCN1A Loss-of-function Mutation. Translational Psychiatry. Jan 5;6:e703.

    25.    Long Y, Miao X, Rong L, Sheng D, Jeanette B, Guokai C, Ferri S, Ulrich B, Wang M, Marugan J, Muro S, Li Z, Brady R, Zheng W. (2016) Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A. Stem Cells Translational Medicine. 2016;5:1–12

    26.    Ma W, Li C, Yin S, Liu J, Gao C, Lin Z, Huang R, Huang J, Li Z. (2015) Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells. Free Radical Biology & Medicine. 89: 1003–13.

    27.    He X, Deng F, Ge Jin, Yan X, Pan A, Li Z. (2015) Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion. Neural Regeneration Research. 10(9):1450-6.

    28.    Yang Y, Xie M, Li J, Hu X, Patrylo PR, Luo X, Cai Y, Li Z, Yan X. (2015). Prenatal genesis of layer II doublecortin expressing neurons in neonatal and young adult guinea pig cerebral cortex. Front Neuroanat. 9, 109.

    29.    Zhou Y, Hou G, He S, Xiao Z, Xu H, Qiu Y, Jiang S, Zheng H, Li Z. (2015) Psora-4, a Kv1.3 Blocker, enhances differentiation and maturation in neural progenitor cells. CNS Neuroscience & Therapeutics 21(7):558-67.

    30.    Gao C, Yu Q, Xu H, Zhang L, Liu J, Jie Y, Ma W, Samways DS, Li Z. (2015) Roles of the lateral fenestration residues of the P2X4 receptor that contribute to the channel function and the deactivation effect of ivermectin. Purinergic Signal. PMID: 25847072

    31.    Wang X, Zhong X, Li Z, Wang H, Zhang J, Li F, Zhang J, Dai R, Zhou X, Li C, Li Z, Bi F. (2015) Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats. BMC Neurosci.16: 14.

    32.    Liu C, Yang Y, Hu X, Li J, Zhang X, Cai Y, Li Z, Yan X. (2015). Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex. Front Neuroanat. 9, 11.

    33.    Zhang L, Deng S, Li Z. (2015) ATP Binding and Channel Activation in P2X Receptors. Receptors & Clinical Investigation. 2(1), 10-14800.

    34.Deng S, Hou G, Xue Z, Zhang L, Zhou Y, Liu C, Liu Y, Li Z. (2015) Vitamin E isomer δ-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel. Neurosci Lett. 12;585C:166-